The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
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“Indeed, a reanalysis of previously published data26 showed that Havcr2 expression is reduced in Tgfbr2-deficient primary microglia (Fig. 1g).”
From Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease (2025) · cites this paper as [26]
In the citing paper
“loss of TGFβ signalling induces a gene-expression signature similar to the MGnD signature26–28”
From Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease (2025) · cites this paper as [26]
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“Deficiency of microglial TGFβ signalling spontaneously causes fatally progressive motor dysfunction11,26,27, whereas Havcr2cKO mice were viable and healthy, a result that is probably due to the distinctions between gene expression in Havcr2cKO and Tgfbr2cKO microglia (Figs. 2a,b and 3m and Extended Data Fig. 3).”
From Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease (2025) · cites this paper as [26]
In the citing paper
“TGFβ signalling is a key regulator of homeostasis and limits microglial hyperreactivity, and loss of TGFβ signalling induces a gene-expression signature similar to the MGnD signature26–28.”
From Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease (2025) · cites this paper as [26]
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Self-citationIdentification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Self-citationMicroglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089
Bruttger, J., Karram, K., Wörtge, S., Regen, T., Marini, F., Hoppmann, N., Klein, M., Blank, T., Yona, S., Wolf, Y., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.012 · Cited by 634
Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties
Novitskiy, S. V., Pickup, M. W., Chytil, A., Polosukhina, D., Owens, P., & Moses, H. L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211639 · Cited by 79
Mice deficient in NRROS show abnormal microglial development and neurological disorders
Wong, K., Noubade, R., Manzanillo, P., Ota, N., Foreman, O., Hackney, J. A., Friedman, B. A., Pappu, R., Scearce-Levie, K., & Ouyang, W. (2017) · Nature Immunology · doi:10.1038/ni.3743 · Cited by 71
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Self-citationThe identity and function of microglia in neurodegeneration
Song, W. M., & Colonna, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0212-1 · Cited by 308
Lund, H., Pieber, M., Parsa, R., Han, J., Grommisch, D., Ewing, E., Kular, L., Needhamsen, M., Espinosa, A., Nilsson, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07295-7 · Cited by 249
Self-citationMicroglia in Brain Development, Homeostasis, and Neurodegeneration
Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043515 · Cited by 212
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01627-6 · Cited by 202
Self-citationMicroglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation
Berglund, R., Guerreiro-Cacais, A. O., Adzemovic, M. Z., Zeitelhofer, M., Lund, H., Ewing, E., Ruhrmann, S., Nutma, E., Parsa, R., Thessen-Hedreul, M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5077 · Cited by 149
Self-citationMargeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.014 · Cited by 130
Self-citationImmune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
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Self-citationTGF-β Signaling in Microglia: A Key Regulator of Development, Homeostasis and Reactivity
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Immunological signatures in frontotemporal lobar degeneration
Sirkis, D. W., Bonham, L. W., Karch, C. M., & Yokoyama, J. S. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000665 · Cited by 14
CNS macrophage contributions to myelin health
Hoffmann, A., & Miron, V. E. (2024) · Immunological Reviews · doi:10.1111/imr.13416 · Cited by 13
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
Zhu, K., Liu, Y., Min, J.-H., Joshua, V., Lin, J., Li, Y., Kreutzmann, J. C., Guo, Y., Xia, W., Mohammadi, E., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-025-02161-4 · Cited by 11
Self-citation
Metadata
- Authors
- Lund, H., Pieber, M., Parsa, R., Grommisch, D., Ewing, E., Kular, L., Han, J., Zhu, K., Nijssen, J., Hedlund, E., Needhamsen, M., Ruhrmann, S., Guerreiro-Cacais, A. O., Berglund, R., Forteza, M. J., Ketelhuth, D. F. J., Butovsky, O., Jagodic, M., Zhang, X.-M., & Harris, R. A.
- ORCID
- Venue
- Nature Immunology
- Published
- 2018-04-16
- Volume
- 19
- Issue
- 5
- Pages
- 1-7
- ISSN
- 1529-2908
- 1529-2916
- PMC
- PMC7309278
- Cited by
- 82
- References
- 6
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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