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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Open accessAbstract
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to CTL019.
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“Further, transduction of cells other than T lymphocytes (e.g. malignant blasts) has been observed, creating the risk of engineering CARs into cancer cells, giving rise to CAR-resistant tumor cells (48).”
From Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy (2021) · cites this paper as [48]
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Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,457
dbSNP: the NCBI database of genetic variation
Sherry, S. T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.308 · Cited by 7,502
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735
Self-citationChimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
Maude, S. L., Frey, N., Shaw, P. A., Aplenc, R., Barrett, D. M., Bunin, N. J., Chew, A., Gonzalez, V. E., Zheng, Z., Lacey, S. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407222 · Cited by 5,413
Self-citationChimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
Grupp, S. A., Kalos, M., Barrett, D., Aplenc, R., Porter, D. L., Rheingold, S. R., Teachey, D. T., Chew, A., Hauck, B., Wright, J. F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215134 · Cited by 3,509
Self-citationSöker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81402-6 · Cited by 2,493
Kalos, M. D., Levine, B. L., Porter, D. L., Katz, S. I., Grupp, S. A., Bagg, A., & June, C. H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002842 · Cited by 2,417
Self-citationChimeric Antigen Receptor Therapy
June, C. H., & Sadelain, M. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1706169 · Cited by 2,411
Self-citationCOSMIC: exploring the world's knowledge of somatic mutations in human cancer
Forbes, S. A., Beare, D. M., Gunasekaran, P., Leung, K., Bindal, N., Boutselakis, H., Ding, M., Bamford, S., Cole, C. G., Ward, S. A., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1075 · Cited by 2,294
Fry, T. J., Shah, N. N., Orentas, R. J., Stetler‐Stevenson, M., Yuan, C. M., Ramakrishna, S., Wolters, P. L., Martin, S. C., Delbrook, C., Yates, B., et al. (2017) · Nature Medicine · doi:10.1038/nm.4441 · Cited by 1,363
Self-citationSotillo, E., Barrett, D. M., Black, K. L., Bagashev, A., Oldridge, D. A., Wu, G. S., Sussman, R. T., Lanauze, C. B., Ruella, M., Gazzara, M. R., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1020 · Cited by 1,279
Self-citationMilone, M. C., Fish, J. D., Carpenito, C., Carroll, R. G., Binder, G. K., Teachey, D., Samanta, M., Lakhal, M., Gloss, B., Danet-Desnoyers, G., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.83 · Cited by 1,197
Self-citationImai, C., Mihara, K., Andreánsky, M., Nicholson, I., Pui, C., Geiger, T. L., & Campana, D. (2004) · Leukemia · doi:10.1038/sj.leu.2403302 · Cited by 844
Gardner, R., Wu, D., Cherian, S., Fang, M., Hanafi, L., Finney, O. C., Smithers, H. M., Jensen, M. C., Riddell, S. R., Maloney, D. G., et al. (2016) · Blood · doi:10.1182/blood-2015-08-665547 · Cited by 751
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Haso, W. M., Lee, D. W., Shah, N. N., Stetler‐Stevenson, M., Yuan, C. M., Pastan, I. H., Dimitrov, D. S., Morgan, R. A., FitzGerald, D. J., Barrett, D. M., et al. (2012) · Blood · doi:10.1182/blood-2012-06-438002 · Cited by 579
Self-citationDual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Ruella, M., Barrett, D. M., Kenderian, S. S., Shestova, O. E., Hofmann, T. J., Perazzelli, J., Klichinsky, M., Aikawa, V., Nazimuddin, F., Kozlowski, M. S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87366 · Cited by 571
Self-citationAn Enhanced Green Fluorescent Protein Allows Sensitive Detection of Gene Transfer in Mammalian Cells
Zhang, G., Gurtu, V., & Kain, S. R. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1573 · Cited by 394
CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency
van Zelm, M. C., Smet, J., Adams, B., Mascart, F., Schandené, L., Janssen, F., Ferster, A., Kuo, C.-C., Levy, S., van Dongen, J. J. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39748 · Cited by 380
Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies
Ruella, M., & Maus, M. V. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.09.003 · Cited by 292
Self-citationBraig, F., Brandt, A. P., Goebeler, M., Tony, H., Kurze, A.-K., Nollau, P., Bumm, T. G. P., Böttcher, S., Bargou, R. C., & Binder, M. (2016) · Blood · doi:10.1182/blood-2016-05-718395 · Cited by 275
Tedder, T. F., & Isaacs, C. M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.2.712 · Cited by 196
Ruella, M., Kenderian, S. S., Shestova, O. E., Fraietta, J. A., Qayyum, S., Zhang, Q., Maus, M. V., Liu, X., Nuñez-Cruz, S., Klichinsky, M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1527 · Cited by 190
Self-citationSalvatore, G., Beers, R., Margulies, I., Kreitman, R. J., & Pastan, I. H. (2002) · PubMed · Cited by 153
Jena, B., Maiti, S. N., Huls, H. M., Singh, H., Lee, D. A., Champlin, R. E., & Cooper, L. J. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057838 · Cited by 137
Marcucci, K. T., Jadlowsky, J. K., Hwang, W., Suhoski, M. M., Gonzalez, V. E., Kulikovskaya, I. M., Gupta, M., Lacey, S. F., Plesa, G., Chew, A., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.10.012 · Cited by 137
Self-citationEstimating abundances of retroviral insertion sites from DNA fragment length data
Berry, C. C., Gillet, N. A., Melamed, A., Gormley, N. A., Bangham, C. R. M., & Bushman, F. D. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts004 · Cited by 134
Self-citationINSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
Sherman, E. A., Nobles, C. L., Berry, C. C., Six, E. M., Wu, Y., Dryga, A., Malani, N., Male, F., Reddy, S. G., Bailey, A., et al. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2016.11.002 · Cited by 128
Self-citationHeinz, N., Schambach, A., Galla, M., Maetzig, T., Baum, C., Loew, R., & Schiedlmeier, B. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.099 · Cited by 93
Swennenhuis, J. F., Reumers, J., Thys, K., Aerssens, J., & Terstappen, L. W. M. M. (2013) · Genome Medicine · doi:10.1186/gm510 · Cited by 88
Barrett, D. M., Seif, A. E., Carpenito, C., Teachey, D. T., Fish, J. D., June, C. H., Grupp, S. A., & Reid, G. S. D. (2011) · Blood · doi:10.1182/blood-2011-04-346528 · Cited by 56
Self-citationIdentification and characterization of fully human anti-CD22 monoclonal antibodies
Xiao, X., Ho, M., Zhu, Z., Pastan, I. H., & Dimitrov, D. S. (2009) · mAbs · doi:10.4161/mabs.1.3.8113 · Cited by 38
NRP-1/CD304 Expression in Acute Leukemia
Meyerson, H. J., Blidaru, G., Edinger, A., Osei, E. S., Schweitzer, K., Fu, P., & Ho, L. (2011) · American Journal of Clinical Pathology · doi:10.1309/ajcp6vdbl4brxrqa · Cited by 22
Ruella, M., Maude, S. L., Engels, B., Barrett, D. M., Frey, N. V., Marcucci, K. T., Shestova, O. E., Singh, N., Perazzelli, J., Christian, D. A., et al. (2017) · Blood · doi:10.1182/blood.v130.suppl_1.807.807 · Cited by 6
Self-citationMueller, K. T., Chakraborty, A., Wood, P. A., Awasthi, R., Quintás‐Cardama, A., Han, X., Maude, S. L., Grupp, S. A., Porter, D. L., Frey, N. V., et al. (2016) · Blood · doi:10.1182/blood.v128.22.220.220 · Cited by 4
Self-citation
Research works printed but not linked: 1
- Salvatore, G., Beers, R., Margulies, I., Kreitman, R. J. & Pastan, I. Clin. Cancer Res. 8, 995–1002 (2002).
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Rafiq, S., Hackett, C. S., & Brentjens, R. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0297-y · Cited by 1,525
Mechanisms of resistance to CAR T cell therapy
Shah, N. N., & Fry, T. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0184-6 · Cited by 999
Self-citationRecent advances and discoveries in the mechanisms and functions of CAR T cells
Larson, R. C., & Maus, M. V. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00323-z · Cited by 852
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Feins, S., Kong, W., Williams, E. F., Milone, M. C., & Fraietta, J. A. (2019) · American Journal of Hematology · doi:10.1002/ajh.25418 · Cited by 614
Self-citationIonizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636
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Metadata
- Authors
- Ruella, M., Xu, J., Barrett, D. M., Fraietta, J. A., Reich, T. J., Ambrose, D. E., Klichinsky, M., Shestova, O., Patel, P. R., Kulikovskaya, I., Nazimuddin, F., Bhoj, V. G., Orlando, E. J., Fry, T. J., Bitter, H., Maude, S. L., Levine, B. L., Nobles, C. L., Bushman, F. D., Young, R. M., Scholler, J., Gill, S. I., June, C. H., Grupp, S. A., Lacey, S. F., & Melenhorst, J. J.
- Affiliations
- Abramson Cancer Center (US)
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Children's Hospital Colorado (US)
- Corresponding author
- June, Carl H.
- Melenhorst, J. Joseph
- ORCID
- Ruella, Marco
- Xu, Jun
- Barrett, David M.
- Fraietta, Joseph A.
- Reich, Tyler J.
- Klichinsky, Michael
- Patel, Prachi R.
- Kulikovskaya, Irina
- Bhoj, Vijay G.
- Orlando, Elena J.
- Fry, Terry J.
- Bitter, Hans
- Maude, Shannon L.
- Levine, Bruce L.
- Nobles, Christopher L.
- Bushman, Frederic D.
- Young, Regina M.
- Scholler, John
- Gill, Saar I.
- June, Carl H.
- Grupp, Stephan A.
- Lacey, Simon F.
- Melenhorst, J. Joseph
- Venue
- Nature Medicine
- Published
- 2018-10
- Volume
- 24
- Issue
- 10
- Pages
- 1499-1503
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6511988
- OpenAlex
- W2893691711
- Cited by
- 659
- References
- 36
- Citations by year
- 2026: 61 · 2025: 73 · 2024: 83 · 2023: 84 · 2022: 83 · 2021: 91 · 2020: 91 · 2019: 78 · 2018: 14
- FWCI
- 25.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K99CA212302, R00CA212302, T32CA009140, R01CA120409, P01CA214278)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- CAR T-cell therapy, CD19, tisagenlecleucel, B-cell acute lymphoblastic leukemia, CAR T cell manufacturing, relapse
- MeSH terms
- Receptors, Chimeric Antigen, Adult, Epitopes, B-Lymphocytes, Humans, Leukemia, Male, Receptors, Antigen, T-Cell, T-Lymphocytes, Antigens, CD19, Drug Resistance, Neoplasm, Young Adult, Cell- and Tissue-Based Therapy
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