The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Open accessAbstract
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to CTL019.
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“Further, transduction of cells other than T lymphocytes (e.g. malignant blasts) has been observed, creating the risk of engineering CARs into cancer cells, giving rise to CAR-resistant tumor cells (48).”
From Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy (2021) · cites this paper as [48]
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Self-citationChimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
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Self-citationChimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
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Engineering strategies to overcome the current roadblocks in CAR T cell therapy
Rafiq, S., Hackett, C. S., & Brentjens, R. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0297-y · Cited by 1,525
Mechanisms of resistance to CAR T cell therapy
Shah, N. N., & Fry, T. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0184-6 · Cited by 999
Self-citationRecent advances and discoveries in the mechanisms and functions of CAR T cells
Larson, R. C., & Maus, M. V. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00323-z · Cited by 852
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
Feins, S., Kong, W., Williams, E. F., Milone, M. C., & Fraietta, J. A. (2019) · American Journal of Hematology · doi:10.1002/ajh.25418 · Cited by 614
Self-citationIonizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636
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Metadata
- Authors
- Ruella, M., Xu, J., Barrett, D. M., Fraietta, J. A., Reich, T. J., Ambrose, D. E., Klichinsky, M., Shestova, O., Patel, P. R., Kulikovskaya, I., Nazimuddin, F., Bhoj, V. G., Orlando, E. J., Fry, T. J., Bitter, H., Maude, S. L., Levine, B. L., Nobles, C. L., Bushman, F. D., Young, R. M., Scholler, J., Gill, S. I., June, C. H., Grupp, S. A., Lacey, S. F., & Melenhorst, J. J.
- Affiliations
- Abramson Cancer Center (US)
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Children's Hospital Colorado (US)
- Corresponding author
- June, Carl H.
- Melenhorst, J. Joseph
- ORCID
- Ruella, Marco
- Xu, Jun
- Barrett, David M.
- Fraietta, Joseph A.
- Reich, Tyler J.
- Klichinsky, Michael
- Patel, Prachi R.
- Kulikovskaya, Irina
- Bhoj, Vijay G.
- Orlando, Elena J.
- Fry, Terry J.
- Bitter, Hans
- Maude, Shannon L.
- Levine, Bruce L.
- Nobles, Christopher L.
- Bushman, Frederic D.
- Young, Regina M.
- Scholler, John
- Gill, Saar I.
- June, Carl H.
- Grupp, Stephan A.
- Lacey, Simon F.
- Melenhorst, J. Joseph
- Venue
- Nature Medicine
- Published
- 2018-10
- Volume
- 24
- Issue
- 10
- Pages
- 1499-1503
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6511988
- OpenAlex
- W2893691711
- Cited by
- 659
- References
- 36
- Citations by year
- 2026: 61 · 2025: 73 · 2024: 83 · 2023: 84 · 2022: 83 · 2021: 91 · 2020: 91 · 2019: 78 · 2018: 14
- FWCI
- 25.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K99CA212302, R00CA212302, T32CA009140, R01CA120409, P01CA214278)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- CAR T-cell therapy, CD19, tisagenlecleucel, B-cell acute lymphoblastic leukemia, CAR T cell manufacturing, relapse
- MeSH terms
- Receptors, Chimeric Antigen, Adult, Epitopes, B-Lymphocytes, Humans, Leukemia, Male, Receptors, Antigen, T-Cell, T-Lymphocytes, Antigens, CD19, Drug Resistance, Neoplasm, Young Adult, Cell- and Tissue-Based Therapy
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