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Predicting the early risk of chronic kidney disease in patients with diabetes using real-world data
Abstract
Diagnostic procedures, therapeutic recommendations, and medical risk stratifications are based on dedicated, strictly controlled clinical trials. However, a plethora of real-world medical data exists, whereupon the increase in data volume comes at the expense of completeness, uniformity, and control. Here, a case-by-case comparison shows that the predictive power of our real world data-based model for diabetes-related chronic kidney disease outperforms published algorithms, which were derived from clinical study data.
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“Ravizza et al. [74] employed a data-driven feature selection strategy to identify seven key predictors, including age, BMI, eGFR, creatinine, glucose, albumin, and HbA1c, for chronic kidney disease (CKD) prediction with large-scale EHR data.”
From Artificial intelligence-powered prediction of diabetic complications: from clinical data to molecular omics (2026) · cites this paper as [74]
In the citing paper
“For example, a partnership among Roche Diabetes Care GmbH, IBM, Eli Lilly and Company, the Regenstrief Institute, and the Indiana Biosciences Research Institute developed a predictive algorithm identifying patients at risk for chronic kidney disease [43].”
From Evolution of clinical Health Information Exchanges to population health resources: a case study of the Indiana network for patient care (2025) · cites this paper as [43]
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Metadata
- Authors
- Ravizza, S., Huschto, T., Adamov, A., Böhm, L., Büsser, A., Flöther, F. F., Hinzmann, R., König, H., McAhren, S. M., Robertson, D. H., Schleyer, T., Schneidinger, B., & Petrich, W.
- Affiliations
- Roche Diabetes Care GmbH (Germany) (DE)
- Eli Lilly (United States) (US)
- Indiana Biosciences Research Institute (US)
- Regenstrief Institute (US)
- Corresponding author
- Petrich, Wolfgang
- ORCID
- Venue
- Nature Medicine
- Published
- 2019-01
- Volume
- 25
- Issue
- 1
- Pages
- 57-59
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2900940968
- Cited by
- 167
- References
- 29
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 22 · 2023: 18 · 2022: 27 · 2021: 31 · 2020: 28 · 2019: 10
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Roche Diabetes Care
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- chronic kidney disease, diabetes mellitus, early risk prediction, real-world data, electronic health records, risk prediction algorithm, clinical features
- MeSH terms
- Data Analysis, Algorithms, Diabetes Mellitus, Humans, Prognosis, Sample Size, Area Under Curve, Renal Insufficiency, Chronic
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