Cited by 420Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomicsEvolution and Genetic Dynamics

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

The distribution of cellular turnover in the human body

Sender, Ron, Milo, Ron·2021·Nature Medicine

DOI 10.1038/s41591-020-01182-9

Open this paper in CoChat — free account

Abstract

We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive quantitative description of cellular turnover. We found a total cellular mass turnover of 80 ± 20 grams per day, dominated by blood cells and gut epithelial cells. In terms of cell numbers, close to 90% of the (0.33 ± 0.02) × 10 12 cells per day turnover was blood cells.

Integrity signals

Registry

Crossref · 10.1038/s41591-020-01182-9

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425
Self-citation
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
The expensive-tissue hypothesis: The brain and the digestive system in human and primate evolution
Aiello, L. C., & Wheeler, P. (1995) · Current Anthropology · doi:10.1086/204350 · Cited by 2,291
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050
Self-citation
Basic anatomical and physiological data for use in radiological protection: reference values
Valentin, J. (2002) · Annals of the ICRP · doi:10.1016/s0146-6453(03)00002-2 · Cited by 2,024
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
Tomasetti, C., & Vogelstein, B. (2015) · Science · doi:10.1126/science.1260825 · Cited by 1,927
Report of the task group on reference man
(1979) · Annals of the ICRP · doi:10.1016/0146-6453(79)90123-4 · Cited by 1,715
Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
Colotta, F., Re, F., Polentarutti, N., Sozzani, S., & Mantovani, A. (1992) · Blood · doi:10.1182/blood.v80.8.2012.2012 · Cited by 1,165
An estimation of the number of cells in the human body
Bianconi, E., Piovesan, A., Facchin, F., Beraudi, A., Casadei, R., Frabetti, F., Vitale, L., Pelleri, M. C., Tassani, S., Piva, F., et al. (2013) · Annals of Human Biology · doi:10.3109/03014460.2013.807878 · Cited by 1,012
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L. (2010) · Blood · doi:10.1182/blood-2010-01-259028 · Cited by 873

Show all 62 references

Research works printed but not linked: 3

Nozick, R. Philosophical Explanations (The Belknap Press, 1981).
Forte, J. G. in Comprehensive Human Physiology From Cellular Mechanisms to Integration (eds Greger, R. & Windhorst, U.) 1239–1258 (Springer-Verlag, 1996).
Apostoaei, A. J. & Trabalka, J. R. Review, synthesis and application of information on the human lymphatic system to radiation dosimetry for chronic lymphocitic leukemia. 12–39 (SENES Oak Ridge, Inc. Center for Risk Analysis, 2010).

Sorted by citations

Items 301–400 of 417

Adaptor protein supersaturation drives innate immune signaling and cell fatePreprint
Gama, A. R., Miller, T., Venkatesan, S., Lange, J. J., Wu, J., Song, X., Bradford, W. D., Cook, M. E., Unruh, J. R., & Halfmann, R. (2026) · eLife · doi:10.7554/elife.107962.2 · Cited by 1
Stem cell function in vivo is supported by an alternative glycolysis endpointPreprint
Kwarteng, E. O., Li, Y., Nguyen, D. L., & Agathocleous, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.30.715412 · Cited by 1
A non-lytic membrane permeabilization program drives epithelial cell turnover in vivoPreprint
Morikawa, M., & Yoo, S. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.06.736761 · Cited by 1
Molar extraction alters gastric mucosa and ghrelin expression in rat stomach: A preliminary study
Shams, S. M., Watari, I., Saito, E., & Ono, T. (2022) · APOS Trends in Orthodontics · doi:10.25259/apos_133_2021
Reading the organism: Studying the whole to give meaning to the partsPreprint
Moore-Anderson, C. (2022) · doi:10.31235/osf.io/jmv39
Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axisPreprint
Dressel, N., Natusch, L., Munz, C. M., Ramon, S. C., Morcos, M. N. F., Loff, A., Hiller, B., Lesche, M., Dahl, A., Luksch, H., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.24.497496 · Cited by 1
Investigação do papel de STING na perda da função anti-inflamatória em macrófagos deficientes em LAP no contexto da eferocitose
Alzamora-Terrel, D. L. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2022.tde-08092022-155732
Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scalesPreprint
Timonina, V., Tretiakov, E. O., Goncharov, A., Владимирович, Г. К., Fellay, J., & Popadin, K. Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.11.516130
Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function
Semedo, P., Pereira, G., de Almeida, D. C., & Câmara, N. O. S. (2023) · Biochemistry · doi:10.5772/intechopen.109273
Islamic Theology in Scientific TheoryPreprint
Wali, H. (2023) · doi:10.31219/osf.io/fcmpv
Principles for Understanding Mechanisms of Cell Death and Their Role in Cancer Biology
Diepstraten, S. T., Marca, J. E. L., Huang, A. D. C. S., & Kelly, G. L. (2023) · Wiley eBooks · doi:10.1002/9781119819950.ch10
Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulationPreprint
Encarnacion‐Garcia, M. R., la Torre‐Baez, R. D., Hernandez‐Cueto, M. A., Velázquez‐Villegas, L. A., Candelario‐Martínez, A., Horta‐López, P. H., Montoya‐García, A., Jaimes‐Ortega, G. A., Lopez-Bailon, L. U., Piedra-Quintero, Z. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.13.540666
Cell age drives asynchronous transcriptome aging
Yang, M., Harrison, B. R., & Promislow, D. E. L. (2023) · doi:10.1101/2023.05.31.543091
References
(2023) · Wiley eBooks · doi:10.1002/9781394236329.refs
Prolonging Human Lifespan by Consciousness Integration or Brain IntegrationPreprint
Xie, Y. (2023) · Preprints.org · doi:10.20944/preprints202309.2114.v1
Dissecting the cellular states and fates of shed mouse intestinal cells
(2023) · Nature Metabolism · doi:10.1038/s42255-023-00907-7
Ancient Synteny Links Metabolism with Erythroid DevelopmentPreprint
Preston, A. E., Frost, J. N., Badat, M., Teh, M. R., Armitage, A. E., Norfo, R., Wideman, S. K., Hanifi, M., White, N., Roy, N. B. A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4615452
Matter and Living Matter
Nadin, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-43957-5_4
Is death a living being?
Ali, A. M., Ali, A. A., & Ali, A. A. (2023) · International Journal of Science and Technology Research Archive · doi:10.53771/ijstra.2023.5.2.0294
Diet and differentiation in the Roman province of Macedonia: A bioarchaeological approach
Vergidou, C. (2024) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.901118017 · Cited by 1
eLife assessment: What fraction of cellular DNA turnover becomes cfDNA?
Cooper, J. A. (2024) · eLife · doi:10.7554/elife.89321.3.sa0
An investigation of cell turnover in the planarian epidermis
Lee, J.-R. (2024) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10443
Introduction and barriers in cancer therapeutics
Loveleen, L., Nimesh, S., & Gupta, N. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15401-0.00014-2
Cell Mysteries and the Paradigm of Sexual Reproduction
Paunesku, T. (2024) · Zygon® · doi:10.16995/zygon.15420
The DivisionCounter, a method for counting large ranges of cell divisions in vivo, reveals cell dynamics of leukemic cell killing via CAR-T therapyPreprint
Hustin, L., Conrad, C., Liu, C., Fuentealba, J. R., Menegatti, S., Shneer, S., Battistella, A., Tabarin, F., Weber, T., Amigorena, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.24.600543
Latent mitotic vulnerability of AML cells induced by therapeutic agentsPreprint
Niikura, R., Yabushita, T., Yamamoto, S., Suzuki, H., Fukuyama, M., Hata, S., Goyama, S., Kitamura, T., Chinen, T., & Kitagawa, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.27.600939
The method for assessing the specificity of developing CAR therapies
Prikhodko, I. V., & Guria, G. (2024) · Biophysical Reports · doi:10.1016/j.bpr.2024.100172
Chaotic dynamics for homeostatic hematopoiesisPreprint
Jia, D., Salazar-Cavazos, E., West, T., Liang, S.-H., Costa, R., Clavijo-Salomon, M. A., Huang, A., Trinchieri, G., Lionakis, M. S., Mukherjee, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.16.608266
Cell-free chromatin particles damage genomic DNA of healthy cells via an ROS-independent mechanismPreprint
Jain, K., Raghuram, G. V., Lopes, R. S., Khare, N. K., Shabrish, S., & Mittra, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.16.608226
Evolution of transmissible cancers: An adaptive, plastic strategy of selfish genetic elements?
Reeve, H. K., & Pfennig, D. W. (2024) · iScience · doi:10.1016/j.isci.2024.110740
Near the Death
(2024) · Advances in religious and cultural studies (ARCS) book series · doi:10.4018/978-1-6684-8509-5.ch010
Human-Environment Model, Self-Regulation, and Rhythms Coordination
(2024) · Advances in religious and cultural studies (ARCS) book series · doi:10.4018/978-1-6684-8509-5.ch008
Standardized assessment of energy excretion in healthy adults: a novel methodology
Bao, R., Guo, Y., Hu, Y., Ning, G., Pan, S., & Wang, W. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.12.016
Author response: Horizontally transferred cell-free chromatin particles function as autonomous “predatory” genomes and vehicles for transposable elements within host cells
Banerjee, S., Shende, S. S., Kata, L., Lopes, R. S., Praveen, S., Joshi, R., Khare, N. K., Raghuram, G. V., Shabrish, S., & Mittra, I. (2024) · eLife · doi:10.7554/elife.103771.1.sa0
Physiological Phenomena that Cause Troubles and Suffering or Even Death: Part III: Slow Phenoptosis or Aging
Libertini, G., Corbi, G., Shubernetskaya, O. S., Komici, K., & Ferrara, N. (2024) · Advances in studies of aging and health · doi:10.1007/978-3-031-84877-3_8
Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survivalPreprint
Soehnlein, O., Richter, M., von Göwels, J., Fähndrich, M., Fernandez, C. L., Grohn, K., Schwarz, D., Lang, A., Polzin, A., Farinola, L., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6474581/v1
Intergenerational Enlargement of Human Organs as a Driver of Increased Cancer Risk?
Koufaris, C., & Nicolaidou, V. (2025) · BioEssays · doi:10.1002/bies.70024
Unlocking Universal Principles of Emergent Cohesion and Rule-Making: Revealing the Adaptive Order from Inherent FluxPreprint
Hartman, J. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5354346
The Evolution of Life on Earth
Wandel, A., & Gale, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-64639-3_8
Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk
Colegrove, H., Monnat, R. J., & Feder, A. F. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012915
The impact of normal tissue density on tumor growth and evolution in a 3D whole-tumor model of lung cancerPreprint
Bravo, R., Robertson‐Tessi, M., Antonia, S. J., Gray, J. E., Beg, A. A., Gatenby, R. A., Schabath, M. B., & Anderson, A. R. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.25.676637
Missegregation Causes Potential Cancers Millions of Times every Day
Engvild, K. C. (2025) · Medical Research Archives · doi:10.18103/mra.v13i9.6919
Statistical inference of the cellular origin of chronic myeloid leukemia using a discrete-parameter ABC–PMC frameworkPreprint
Velde, S. V., Engelbeen, C., Pagani, I. S., Ross, D. M., & Hautphenne, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.17.683025
DsDNA breaks inflicted by cell-free chromatin particles selectively target telomeres
Birwatkar, S., Ghosh, T., Selukar, R., Lopes, R. S., Khare, N. K., Raghuram, G. V., Shabrish, S., & Mittra, I. (2025) · Scientific Reports · doi:10.1038/s41598-025-21509-1
Integrating tissue proteomics and bioactive lipid analysis of ovine tissue samples identifies functional relations of bioactive lipids
Hagn, G., Jenner, F., Bileck, A., Gültekin, S., Hámberg, M., Mohr, T. T., Gerner, C., & Gerner, I. (2026) · Frontiers in Pharmacology · doi:10.1101/2025.10.28.685055
Mathematical analysis of G1/S sub-networks in hematopoietic proliferation: Sequential and lineage-specific activation
Hänel, A., Abdelsalam, A., & Tollis, S. (2025) · iScience · doi:10.1016/j.isci.2025.114291
ERAD Activity Distinguishes the Functional Heterogeneity of Hematopoietic Stem CellsPreprint
Peng, Q., Zheng, M., Liu, S., Xie, X., Shen, Z., Wang, T., Liu, H., Mi, W., Zhou, J., Ma, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.01.691501
Skin Regeneration II: Epidermal Homeostasis and the Stem Cell System
Nanba, D. (2025) · Journal of Society of Cosmetic Chemists of Japan · doi:10.5107/sccj.59.184
Additional file 10 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578769
Additional file 4 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578751
Additional file 1 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578742
Additional file 2 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578745
Additional file 16 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578787
Additional file 15 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578784
Additional file 7 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578760
Additional file 17 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578790
Additional file 6 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578757
Additional file 1 of Loss of Y in leukocytes as a risk factor for critical COVID-19 in men
Bruhn‐Olszewska, B., Davies, H., Sarkisyan, D., Juhas, U., Rychlicka-Buniowska, E., Wójcik, M., Horbacz, M., Jąkalski, M., Olszewski, P., Westholm, J. O., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22599859
Additional file 3 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578748
Additional file 14 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578781
Additional file 19 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578796
Additional file 9 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578766
Additional file 13 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578778
Additional file 18 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578793
Additional file 12 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578775
Additional file 8 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578763
Additional file 5 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578754
Additional file 11 of Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Mongelli, A., Panunzi, S., Nesta, M., Zamperla, M. G., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578772
A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis
Boman, R. M., Schleiniger, G. F., Raymond, C., Palazzo, J., Shehab, A., & Boman, B. M. (2025) · Cancers · doi:10.3390/cancers18010044
A CRITICAL ANALYSIS OF THE ROLE OF FASTING IN CLINICAL ONCOLOGY AND AGEING: DISPELLING A MYTH
Shani, S., D’Angelo, M., Mazzarotti, G., Lorenzo, A. D., Martinelli, C., Esposito, T., & Cortellino, S. (2025) · Annals of Research in Oncology · doi:10.48286/aro.2025.116
Cellular Homeostasis: Cell Division, Cell Death, and Virus Infection
Böttger, A., & Moneer, J. (2025) · Springer eBooks · doi:10.1007/978-3-032-03636-0_5
Absence of Neuromuscular Dysfunction in Mice with Gut Epithelium-Restricted Expression of ALS Mutation hSOD1G93A
Dong, L., Li, X., Li, A., Yi, J., Vockery, Y., Chang, Y., Pan, Z., Brotto, M. A. P., & Zhou, J. (2026) · Biomolecules · doi:10.3390/biom16020253
High cancer-associated mutational burden in normal blood of xeroderma pigmentosum group C, but not groups A, D, or F
Fan-Huang, G., Schmidt, E. L., Lee, M., Sun, S., Boull, C. L., Maguiness, S., Vijg, J., Niedernhofer, L. J., & Maslov, A. Y. (2026) · Blood Neoplasia · doi:10.1016/j.bneo.2026.100209
Some Additional Principles of Living Systems Functioning and Their Application for Expanding the Theory of a Possible Typology of National Food Systems Strategies
Brazhnikov, P. (2026) · Systems · doi:10.3390/systems14030230
Modulating efferocytosis in the intestinal epithelial cells during colorectal cancer
Boeckaerts, L., Aaes, T. L., Scheirlinckx, E., Choi, S. M., Incik, Y., Gonçalves, A., Hochepied, T., Vereecke, L., & Ravichandran, K. S. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1740918
eLife Assessment: Adaptor protein supersaturation drives innate immune signaling and cell fate
Sohn, J. (2026) · eLife · doi:10.7554/elife.107962.3.sa0
Investigating the impact of adipose derived media on ovarian cancer: Insights from a 3D in-silico model
Oliver, S., Williams, M., Howard, D., González, D., & Powathil, G. (2026) · Mathematical Biosciences · doi:10.1016/j.mbs.2026.109683
A Systems Framework for Quantifying Programmability and Persistence Across Mammalian Cell TypesPreprint
Chauhan, V., Chen, M., Sridharan, A. T., & Pan, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.27.714669
Estimating the mutation prevalence in the ageing human proteomePreprint
Pechmann, S. (2026) · Research Square · doi:10.21203/rs.3.rs-9315156/v1
How Somatic Mutations cause Aging without Causing AgingPreprint
Wolf, A. M. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6431458
Quantifying Haematopoietic Cell Dynamics
Hustin, L. (2022) · theses.fr (ABES) · doi:10.70675/48546646z0fa0z4e9bzb5a0zb1067f26721d
Loss of ABC transporters, White, Brown, and Scarlet, prevents increase in mitotic divisions of germline stem cells in response to mating in Drosophila melanogaster
Wright, M. P., Vladimirova, A., Aston, H. M., Malpe, M. S., & Schulz, C. (2026) · PLoS ONE · doi:10.1371/journal.pone.0346783
Physical principles of size and density regulation in the cell and the cell nucleus
Rollin, R. (2022) · doi:10.70675/d89d120dz791dz495fz9dcaz0b31472d06e7
Antibiotic tolerance and biofilm formation in the anaerobic intestinal symbiont, bacteroides thetaiotaomicron
Lopes, A. (2022) · theses.fr (ABES) · doi:10.70675/04693f9dze3abz4646z9e5az23de057e2d4e
Developmental origins of the ETO2 : GLIS2 - driven acute megakaryoblastic leukemia in humans and role of the cytokine microenvironment in leukemogenesis
Galant, K. (2024) · theses.fr (ABES) · doi:10.70675/79779fcfz26ccz43bbzaa45z33fc18b50ea2
Caractérisation des mécanismes prédisposant aux néoplasmes myéloprolifératifs et aux hémopathies malignes
Pegliasco, J. (2024) · theses.fr (ABES) · doi:10.70675/12ce08e6zd564z4165zaee7zd80d8186dafd
Assessing the recovery of immune proteins from mummified soft tissue versus archaeological bones
Paasikivi, S., O’Sullivan, R. J., Nordfors, U., Liira, A.-M., Lanigan, L. T., Schuenemann, V. J., & Wilkin, S. (2026) · Journal of Archaeological Science · doi:10.1016/j.jas.2026.106589
Lung–Kidney Axis, Aging, and Cell Turnover: Current Evidence and Perspectives
Ancer-Arellano, A., Gopar‐Cuevas, Y., Chávez-Briones, M.-D.-L., Miranda‐Maldonado, I., Córdova-Zúñiga, S. A., Áncer‐Rodríguez, J., Ortega-Martínez, M., & Jaramillo‐Rangel, G. (2026) · Cells · doi:10.3390/cells15100875
p38MAP kinase regulates senescence in human iPS-derived myocytes
Sato, H., Arakane, M., Mizuno, Y., Sasaki, T., Sakurai, H., Kamihira, M., Enomoto, A., Takafuji, K., Takaya, J., Suzuki, T., et al. (2026) · Aging · doi:10.18632/aging.206385
An organismal view of newborn cell dynamics in mammalian agingPreprint
Lu, Z., Zhou, W. Y., & Cao, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.26.728032
Genetic control of mitotic-to-meiotic transition regulates germline cell survivalPreprint
Garrido‐Maraver, J., Estella, C., & González‐Reyes, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.28.728457
Can Doctors “Teach” the Body to Fight Cancer?
Catanzaro, E., Saeys, E., Saviuk, M. O., Brée, S. D., Turrini, E., & Krysko, D. V. (2026) · Frontiers for Young Minds · doi:10.3389/frym.2026.1768144
The total mass, copy number, and distribution of hormones in the human bloodstream
Sender, R., Kedar, T., Navon, Y., Raz, M., Bikel, S., Hemi, R., Milo, R., & Fuchs, S. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003864
Self-citation
Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes
Krejčová, G., & Bajgar, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1882514
A DNA mass conservation mechanism underpins cellular mtDNA number regulationPreprint
Hussan, J. R., Kobro‐Flatmoen, A., Ruoff, P., & Omholt, S. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.08.737183
List do redakcji Sztuki Leczenia kontynuującej przesłanie prof. Józefa Dietla, chluby Uniwersytetu Jagiellońskiego, analizujący aktualność tez publikacji jego pracy doktorskiej z 1829 roku
Wasilewski, B. (2026) · Sztuka Leczenia · doi:10.4467/18982026szl.26.007.23592
Dynamic Granulocyte Turnover Inferred From cfDNA Methylation Predicts Immunotherapy Benefit in Liver‐Metastatic Small Cell Lung Cancer: A Prospective Biomarker Study
Tang, N., Shang, X., Sun, Y., Zhang, Y., Zhou, H., Ye, S., Tang, X., Guo, J., Zhang, X., Gao, X., et al. (2026) · MedComm · doi:10.1002/mco2.70925
Large-scale simulation of coverage and error rate tradeoffs for cancer detection in cell-free DNA whole-genome sequencing
Chen, L., de Ridder, J., & Jager, M. (2026) · Bioinformatics · doi:10.1093/bioinformatics/btag460
Molecular and Cellular Mechanisms for Maintaining and Restoring Dynamic States of Tissue Homeostasis
Ситдикова, К. К., Черкашенко, В. Н., & Saburina, I. N. (2026) · Biology Bulletin Reviews · doi:10.1134/s2079086425601541
Intranuclear niche: actin-tail mediated nuclear entry by intracellular pathogensPreprint
Cheung, H. C., Iscar, P. R., Plum, M. T. W., & Basler, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.23.746248

Authors: Sender, R., & Milo, R.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Milo, Ron
ORCID: Sender, Ron
Milo, Ron
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2021-01
Volume: 27
Issue: 1
Pages: 45-48
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-020-01182-9
OpenAlex: W3120885077
Cited by: 420
References: 62
Citations by year: 2026: 60 · 2025: 79 · 2024: 95 · 2023: 94 · 2022: 69 · 2021: 23
FWCI: 24.90
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation (Grant 740/16)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: cell turnover, cell death, tissue regeneration, blood cells, intestinal epithelial cells, cell lifespan, human body, cell number
MeSH terms: Blood Cells, Epithelial Cells, Humans, Cellular Senescence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The distribution of cellular turnover in the human body

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks