The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies
Abstract
Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This highlights the possible utility of liquid biopsies for molecular genotyping, facilitating more rapid patient access to targeted therapy options in the future (30).”
From Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRAS G12C-Mutated Metastatic Colorectal Cancer (2024) · cites this paper as [30]
Citations
Cites
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Chalmers, Z. R., Connelly, C. F., Fabrizio, D., Gay, L., Ali, S. M., Ennis, R., Schrock, A., Campbell, B., Shlien, A., Chmielecki, J., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0424-2 · Cited by 3,519
OncoKB: A Precision Oncology Knowledge Base
Chakravarty, D., Gao, J., Phillips, S. M., Kundra, R., Zhang, H., Wang, J., Rudolph, J. E., Yaeger, R. D., Soumerai, T. E., Nissan, M. H., et al. (2017) · JCO Precision Oncology · doi:10.1200/po.17.00011 · Cited by 2,783
Maintenance Olaparib for Germline BRCA -Mutated Metastatic Pancreatic Cancer
Golan, T., Hammel, P., Reni, M., Van Cutsem, E., Macarulla, T., Hall, M. J., Park, J.-O., Hochhauser, D., Arnold, D., Oh, D.-Y., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1903387 · Cited by 2,302
Integrated genomic characterization of oesophageal carcinoma
Sun, Q., Kelsen, D. P., Wiznerowicz, M., Lu, Y., Sandusky, G., Wan, Y., Weinhold, N., Wong, A. M., Carvalho, A. L., Luketich, J. D., et al. (2017) · Nature · doi:10.1038/nature20805 · Cited by 1,869
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer
Kopetz, S., Grothey, A., Yaeger, R., Van Cutsem, E., Desai, J., Yoshino, T., Wasan, H., Ciardiello, F., Loupakis, F., Hong, Y. S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908075 · Cited by 1,491
Self-citationBañales, J. M., Cardinale, V., Carpino, G., Marzioni, M., Andersen, J. B., Invernizzi, P., Lind, G. E., Folseraas, T., Forbes, S. J., Fouassier, L., et al. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.51 · Cited by 1,397
Abou‐Alfa, G. K., Macarulla, T. M., Javle, M. M., Kelley, R. K., Lubner, S. J., Adeva, J., Cleary, J. M., Catenacci, D. V. T., Borad, M. J., Bridgewater, J. A., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30157-1 · Cited by 1,159
Leighl, N. B., Page, R. D., Raymond, V. M., Daniel, D. B., Divers, S. G., Reckamp, K. L., Villalona-Calero, M. A., Dix, D., Odegaard, J. I., Lanman, R. B., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0624 · Cited by 593
Self-citationParikh, A. R., Leshchiner, I., Elagina, L., Goyal, L., Levovitz, C., Siravegna, G., Livitz, D., Rhrissorrakrai, K., Martin, E. E., Van Seventer, E. E., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0561-9 · Cited by 518
Research works printed but not linked: 1
- Li, H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. Preprint at https://arxiv.org/abs/1303.3997 (2013). · arXiv
Cited by
Sorted by citations
Items 101–200 of 383
New developments in targeted therapy for metastatic colorectal cancer
Wong, A. H. N., Ma, B. B. Y., & Lui, R. N.-S. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221148540 · Cited by 23
Gimeno-Valiente, F., Martín-Arana, J., Tébar-Martínez, R., Gambardella, V., Martínez‐Ciarpaglini, C., García-Micó, B., Martínez-Castedo, B., Lucas, B. P.-D., García-Bartolomé, M., Seguí, V., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.102051 · Cited by 21
Current landscape of targeted therapy in esophageal squamous cell carcinoma
Jubashi, A., Kotani, D., Kojima, T., Takebe, N., & Shitara, K. (2024) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2024.101152 · Cited by 21
Localized Small Bowel Adenocarcinoma Management: Evidence Summary
Turpin, A., Amrani, M. E., & Zaanan, A. (2022) · Cancers · doi:10.3390/cancers14122892 · Cited by 21
The Emerging Role of Circulating Tumor DNA in Non-Colorectal Gastrointestinal Cancers
Lee, M. S., Kaseb, A. O., & Pant, S. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3626 · Cited by 21
Yoshii, Y., Okazaki, S., & Takeda, M. (2021) · Life · doi:10.3390/life11080796 · Cited by 21
Osumi, H., Shinozaki, E., Ooki, A., Shimozaki, K., Kamiimabeppu, D., Nakayama, I., Wakatsuki, T., Ogura, M., Takahari, D., Chìn, K., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4384 · Cited by 21
Self-citationEvolution of Precision Oncology, Personalized Medicine, and Molecular Tumor Boards
Fujiwara, Y., Kato, S., & Kurzrock, R. (2026) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2026.05.019 · Cited by 22
Kobayashi, S., Nakamura, Y., Hashimoto, T., Bando, H., Oki, E., Karasaki, T., Horinouchi, H., Ozaki, Y., Iwata, H., Kato, T., et al. (2025) · International Journal of Clinical Oncology · doi:10.1007/s10147-024-02683-0 · Cited by 20
Self-citationCho, M. T., Gholami, S., Gui, D., Tejaswi, S., Fananapazir, G., Abi‐Jaoudeh, N., Jutric, Z., Samarasena, J., Li, X., Valerin, J. B., et al. (2022) · Cancers · doi:10.3390/cancers14020392 · Cited by 20
Progress on angiogenic and antiangiogenic agents in the tumor microenvironment
Xu, J., & Tang, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1491099 · Cited by 20
Zhou, C., Huang, Y., Da, M., Jin, W., & Zhou, F. (2023) · Discover Oncology · doi:10.1007/s12672-023-00704-4 · Cited by 20
Circulating Tumor DNA and Management of Colorectal Cancer
Krell, M., Llera, B. G., & Brown, Z. J. (2023) · Cancers · doi:10.3390/cancers16010021 · Cited by 19
Exploring Predictive and Prognostic Biomarkers in Colorectal Cancer: A Comprehensive Review
Ashouri, K., Wong, A., Mittal, P., Torres‐Gonzalez, L., Lo, J. H., Soni, S., Algaze, S. D., Khoukaz, T., Zhang, W., Yang, Y., et al. (2024) · Cancers · doi:10.3390/cancers16162796 · Cited by 20
Tackling Refractory Metastatic Colorectal Cancer: Future Perspectives
Personeni, N., Smiroldo, V., Giunta, E. F., Prete, M. G., Rimassa, L., Bregni, G., & Sclafani, F. (2021) · Cancers · doi:10.3390/cancers13184506 · Cited by 19
Role of Circulating Tumor DNA in Hematological Malignancy
Ogawa, M., Yokoyama, K., Imoto, S., & Tojo, A. (2021) · Cancers · doi:10.3390/cancers13092078 · Cited by 18
Osumi, H., Shinozaki, E., Nakamura, Y., Esaki, T., Yasui, H., Taniguchi, H., Satake, H., Sunakawa, Y., Komatsu, Y., Kagawa, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50026-4 · Cited by 17
Self-citationMayerhoefer, M. E., Kienzle, A., Woo, S., & Vargas, H. A. (2025) · Radiology · doi:10.1148/radiol.241030 · Cited by 18
Circulating Tumor DNA in Pediatric Cancer
Doculara, L., Trahair, T. N., Bayat, N., & Lock, R. B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.885597 · Cited by 20
Businello, G., Angerilli, V., Lonardi, S., Bergamo, F., Valmasoni, M., Farinati, F., Savarino, E. V., Spolverato, G., & Fassan, M. (2022) · Updates in Surgery · doi:10.1007/s13304-022-01330-5 · Cited by 18
Ueki, A., Yoshida, R., Kosaka, T., & Matsubayashi, H. (2023) · Journal of Human Genetics · doi:10.1038/s10038-023-01153-1 · Cited by 18
Bicocca, V. T., Phillips, K. G., Fischer, D. S., Caruso, V. M., Goudarzi, M., Garcia-Ransom, M., Lentz, P. S., MacBride, A. R., Jensen, B. W., Mazzarella, B. C., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195827 · Cited by 19
Liang, S. I., Quandt, Z., Wienke, S., Wang, J., Gordon, S., Barnett, R. M., Masannat, J., Chang, K., Espenschied, C. R., Quinn, K., et al. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0151 · Cited by 16
Wang, Y., Wang, W., Zhang, T., Yang, Y., Wang, J., Li, C., Xu, X., Wu, Y., Jiang, Y., Duan, J., et al. (2024) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2024.01.008 · Cited by 16
Lorenzo, S. D., Garajová, I., Stefanini, B., & Tovoli, F. (2021) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1928636 · Cited by 16
Pericleous, S., Bhogal, R. H., & Mavroeidis, V. K. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2706189 · Cited by 16
Cha, Y., Kim, S., & Han, S. (2023) · Cancer Research and Treatment · doi:10.4143/crt.2023.446 · Cited by 17
Strategic Insight into the Combination Therapies for Metastatic Colorectal Cancer
Kano, Y., Suenaga, M., & Uetake, H. (2023) · Current Oncology · doi:10.3390/curroncol30070480 · Cited by 18
State of the Art: ctDNA in Upper Gastrointestinal Malignancies
Labiano, I., Huerta, A. E., Arrazubi, V., Hernández-García, I., Mata, E., Gómez, D., Arasanz, H., Vera, R., & Alsina, M. (2023) · Cancers · doi:10.3390/cancers15051379 · Cited by 15
Overview of the role of liquid biopsy in cancer management
Assi, T., Khoury, R., Ibrahim, R., Baz, M., Ibrahim, T., & Cesne, A. L. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101702 · Cited by 15
Roazzi, L., Patelli, G., Bencardino, K. B., Amatu, A., Bonazzina, E. F., Tosi, F., Amoruso, B., Bombelli, A., Mariano, S., Stabile, S., et al. (2024) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2024.02.001 · Cited by 15
Kobayashi, S., Takahashi, S., Nomura, S., Kojima, M., Kudo, M., Sugimoto, M., Konishi, M., Gotohda, N., Taniguchi, H., & Yoshino, T. (2021) · Cancer Medicine · doi:10.1002/cam4.4227 · Cited by 15
Self-citationPrecision Medicine for Colorectal Cancer with Liquid Biopsy and Immunotherapy
Nagayama, S., Low, S., Kiyotani, K., & Nakamura, Y. (2021) · Cancers · doi:10.3390/cancers13194803 · Cited by 16
Self-citationAre extracellular vesicles ready for the clinical laboratory?
Enderle, D., & Noerholm, M. (2022) · Journal of Laboratory Medicine · doi:10.1515/labmed-2022-0064 · Cited by 15
Precision Medicine of Hepatobiliary and Pancreatic Cancers: Focusing on Clinical Trial Outcomes
Tsumura, T., Doi, K., & Marusawa, H. (2022) · Cancers · doi:10.3390/cancers14153674 · Cited by 15
ctDNA Analysis in ERBB2 -Amplified Colorectal Cancer: Biomarker Analysis of the MyPathway Trial
Meric‐Bernstam, F., Raghav, K. P. S., Sweeney, C. J., Swanton, C., Spigel, D. R., Bose, R., Burris, H. A., Friedman, C. F., Espenschied, C. R., Grindheim, J. M., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-2763 · Cited by 14
Palieri, R., Luca, M. D., Balestra, F., Panzetta, G., Lotesoriere, C., Rizzi, F. R., Ricci, A. D., Mastrogiacomo, R., Curri, M. L., Laghi, L., et al. (2025) · Oncology Reviews · doi:10.3389/or.2025.1702932 · Cited by 17
Choo, J. R.-E., Sargsyan, A., Khachatryan, V., Lonardi, S., Pietrantonio, F., Sundar, R., Klempner, S. J., & Janjigian, Y. Y. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01134-1 · Cited by 17
Kanai, M. (2022) · Current Oncology · doi:10.3390/curroncol29100573 · Cited by 14
Udagawa, S., Ooki, A., Shinozaki, E., Fukuda, K., Yamaguchi, K., & Osumi, H. (2023) · Cancers · doi:10.3390/cancers15051473 · Cited by 14
Self-citationCirculating tumor DNA: toward evolving the clinical paradigm of pancreatic ductal adenocarcinoma
Topham, J. T., Renouf, D. J., & Schaeffer, D. F. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231157651 · Cited by 14
Myint, K. Z. Y., Shimabuku, M., Horio, R., Kaneda, M., Shimizu, Y., & Taguchi, J. (2023) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2023.100701 · Cited by 14
Mochizuki, T., Ikegami, M., & Akiyama, T. (2023) · Cancer Science · doi:10.1111/cas.16050 · Cited by 14
Allan, Z., Liu, D. S., Lee, M., Tie, J., & Clemons, N. J. (2024) · Clinical Chemistry · doi:10.1093/clinchem/hvad188 · Cited by 14
Yuan, H., Xu, F., Wang, S., Liu, D., Zhang, H., Zhang, J., Shi, M., Yan, C., & Zhu, Z. (2024) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231225038 · Cited by 14
Macı́as, R. I. R., Kanzaki, H., Berasain, C., Avila, M. A., Marı́n, J. J. G., & Hoshida, Y. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.06.013 · Cited by 14
Suzuki, K., Igata, H., Abe, M., Yamamoto, Y., & small RNA based cancer classification project (2022) · Cancer Science · doi:10.1111/cas.15309 · Cited by 14
Self-citationGermline Testing in Prostate Cancer: When and Who to Test
Sokolova, A. O. (2021) · ONCOLOGY · doi:10.46883/onc.2021.3510.0645 · Cited by 14
Madoff, D. C., Abi‐Jaoudeh, N., Braxton, D. R., Goyal, L., Jain, D., Odisio, B. C., Salem, R., Schattner, M. A., Sheth, R. A., & Li, D. (2022) · The Oncologist · doi:10.1093/oncolo/oyac139 · Cited by 14
Detection of additional occult malignancy through profiling of ctDNA in late-stage cancer patients
Aldea, M. D., Cerbone, L., Bayle, A., Parisi, C., Sarkozy, C., Vasseur, D., Verlingue, L., Blanc‐Durand, F., Mosele, F., Sakkal, M., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.09.002 · Cited by 14
Clinical applications of cell-free DNA-based liquid biopsy analysis
Yazaki, S., Tokura, M., Aiba, H., Kojima, Y., & Shiraishi, K. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102519 · Cited by 13
Ravensbergen, C. J., Kuruc, M. P., Polack, M., Crobach, S., Putter, H., Gelderblom, H. A. J., Roy, D., Tollenaar, R. A. �. �., & Mesker, W. E. (2021) · Cancers · doi:10.3390/cancers14010163 · Cited by 13
Chen, B., Leung, L. L., Qu, X., & Chan, J. Y. K. (2023) · Cancers · doi:10.3390/cancers15061826 · Cited by 13
Clinical Applications of Circulating Tumor DNA Profiling in GI Cancers
Battaglin, F., & Lenz, H. (2024) · JCO Oncology Practice · doi:10.1200/op.24.00167 · Cited by 13
Shah, U. J., Alsulimani, A., Ahmad, F., Mathkor, D. M., Alsaieedi, A., Harakeh, S., Nasiruddin, M., & Haque, S. (2022) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2022.2108994 · Cited by 14
Masucci, M. T., Motti, M. L., Minopoli, M., Carluccio, G. D., & Carriero, M. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076026 · Cited by 13
Nakamura, Y., Yamashita, R., Okamoto, W., Komatsu, Y., Yuki, S., Ueno, M., Kato, K., Taniguchi, H., Kagawa, Y., Denda, T., et al. (2023) · JCO Precision Oncology · doi:10.1200/po.22.00653 · Cited by 13
Self-citationLiquid biopsy for breast cancer and other solid tumors: a review of recent advances
Ohmura, H., Hanamura, F., Okumura, Y., Ando, Y., Masuda, T., Mimori, K., Akashi, K., & Baba, E. (2024) · Breast Cancer · doi:10.1007/s12282-024-01556-8 · Cited by 13
Matsudera, S., Kano, Y., Aoyagi, Y., Tohyama, K., Takahashi, K., Kumaki, Y., Mitsumura, T., Kimura, K., Onishi, I., Takemoto, A., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09856-5 · Cited by 13
Hijioka, S., Nagashio, Y., Maruki, Y., Kawasaki, Y., Takeshita, K., Morizane, C., & Okusaka, T. (2023) · Diagnostics · doi:10.3390/diagnostics13071275 · Cited by 12
Self-citationYi, H., Youk, J., Lim, Y., Roh, H., Kyung, D. S., Kim, H., Bang, D., Keam, B., Kim, T.-M., Kim, M., et al. (2024) · Cancer Research and Treatment · doi:10.4143/crt.2023.1294 · Cited by 12
Plasma ctDNA enables early detection of temozolomide resistance mutations in glioma
Jones, J., Jones, K. L., Wong, S. Q., Whittle, J. R., Goode, D. L., Nguyen, H. P. T., Iaria, J., Stylli, S. S., Towner, J., Pieters, T. A., et al. (2024) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdae041 · Cited by 13
Molecular Landscape and Therapeutic Strategies against Colorectal Cancer
Patel, A., & Gulhati, P. (2024) · Cancers · doi:10.3390/cancers16081551 · Cited by 12
Zeng, Z., & Zhu, Q. C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1382183 · Cited by 12
Circulating tumor DNA predicts venous thromboembolism in patients with cancers
Ma, S., Jiang, J. Y., Kim, R. B., Chiang, E., Tiong, J., Ryu, J. H., Guffey, D., Bandyo, R., Dowst, H., Swinnerton, K. N., et al. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.09.009 · Cited by 12
Biomarkers and Management of Cholangiocarcinoma: Unveiling New Horizons for Precision Therapy
Nishida, N. (2025) · Cancers · doi:10.3390/cancers17071243 · Cited by 12
Self-citationKato, T., Shiota, M., Nishimoto, K., Matsubara, N., Osawa, T., Abe, T., Yasumizu, Y., Tanaka, N., Yamamoto, Y., Ishizuya, Y., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-02985-8 · Cited by 12
Self-citationLakatos, E., Hockings, H., Mossner, M., Huang, W., Lockley, M., & Graham, T. A. (2021) · iScience · doi:10.1016/j.isci.2021.102889 · Cited by 12
Imai, M., Nakamura, Y., Sunami, K., Kage, H., Komine, K., Koyama, T., Amano, T., Ennishi, D., Kanai, M., Kenmotsu, H., et al. (2022) · Cancer Science · doi:10.1111/cas.15504 · Cited by 12
Self-citationMiyo, M., Kato, T., Nakamura, Y., Taniguchi, H., Takahashi, Y., Ishii, M., Okita, K., Ando, K., Yukami, H., Mishima, S., et al. (2021) · Cancer Science · doi:10.1111/cas.15226 · Cited by 12
Self-citationThe current state of molecular profiling in gastrointestinal malignancies
Mukherji, R., Yin, C., Hameed, R., Alqahtani, A. J., Kulasekaran, M., He, A. R., Weinberg, B. A., Marshall, J. L., Hartley, M. L., & Noel, M. S. (2022) · Biology Direct · doi:10.1186/s13062-022-00322-0 · Cited by 13
Aoki, Y., Nakamura, Y., Denda, T., Ohta, T., Esaki, T., Shiozawa, M., Yamaguchi, K., Yamazaki, K., Sunakawa, Y., Kato, T., et al. (2023) · JCO Precision Oncology · doi:10.1200/po.22.00688 · Cited by 11
Self-citationNoji, R., Tohyama, K., Nakamura, S., Naito, T., Oikawa, Y., Kuroshima, T., Tomioka, H., Michi, Y., Ikeda, S., Asakage, T., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010235 · Cited by 11
Hu, Q., Oki, E., Yamada, T., Kashiwada, T., Sonoda, H., Kataoka, M., Kawanaka, H., Tsuji, Y., Makiyama, A., Nakashima, Y., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.6269 · Cited by 11
Self-citationLiquid Biopsy in Pancreatic Ductal Adenocarcinoma: A Review of Methods and Applications
Dubrovsky, G., Ross, A., Jalali, P., & Lotze, M. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011013 · Cited by 11
Liquid biopsy for the management of gastrointestinal cancers
Salehnia, Z., Rezaee, D., Ehtiati, S., Bakhtiari, M., Khalilzad, M. A., & Najafi, S. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120474 · Cited by 11
Longitudinal ctDNA profiling in precision oncology and immunο-oncology
Filis, P., Kyrochristos, I. D., Korakaki, E., Baltagiannis, E. G., Thanos, D., & Roukos, D. H. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103540 · Cited by 12
Ohyama, H., Hirotsu, Y., Amemiya, K., Miura, Y., Hirose, S., Oyama, T., Iimuro, Y., Kojima, Y., Mikata, R., Mochizuki, H., et al. (2023) · Cancer · doi:10.1002/cncr.34717 · Cited by 11
Nakamura, Y., Shitara, K., & Lee, J. (2021) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_321247 · Cited by 11
Self-citationToshida, K., Itoh, S., Yoshizumi, T., Shimagaki, T., Wang, H., Kurihara, T., Toshima, T., Nagao, Y., Harada, N., Oki, E., et al. (2021) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-021-01458-8 · Cited by 11
Self-citationAndo, K., Nakamura, Y., Kitao, H., Shimokawa, M., Kotani, D., Bando, H., Nishina, T., Yamada, T., Yuki, S., Narita, Y., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02378-9 · Cited by 12
Self-citationGray, J. E., Han, J., Telaranta-Keerie, A., Huang, X., Kohlmann, A., Hodge, R. A., Rukazenkov, Y., Chmielecki, J., Espenschied, C. R., Lefterova, M. I., et al. (2023) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2023.10.002 · Cited by 10
Self-citationMajumder, B., Nataraj, N. B., Maitreyi, L., & Datta, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1414376 · Cited by 10
Circulating tumor DNA in colorectal cancer: biology, methods and applications
Chen, H., An, Y., Wang, C., & Zhou, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02220-z · Cited by 10
Circulating tumor DNA for malignant peripheral nerve sheath tumors in neurofibromatosis type 1
Jones, J., Cain, S. A., Pešić-Smith, J. D., Choong, P., Morokoff, A. P., Drummond, K. J., & Dabscheck, G. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03846-z · Cited by 10
CCND1 Copy Number Variation in Circulating Tumor DNA from Luminal B Breast Cancer Patients
Shimazaki, A., Kubo, M., Kurata, K., Takao, Y., Hayashi, S., Harada, Y., Kawaji, H., Kaneshiro, K., Yamada, M., Kai, M., et al. (2022) · Anticancer Research · doi:10.21873/anticanres.15904 · Cited by 10
Jacobs, S. A., Wang, Y., Abraham, J., Feng, H., Montero, A. J., Lipchik, C., Finnigan, M., Jankowitz, R. C., Salkeni, M. A., Maley, S. K., et al. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01823-8 · Cited by 9
Doi, T., Ishikawa, T., Sakakida, T., Itani, J., Sone, D., Morita, R., Kataoka, S., Miyake, H., Seko, Y., Yamaguchi, K., et al. (2024) · Cancer Science · doi:10.1111/cas.16329 · Cited by 9
Self-citationCell‐free DNA for detection and monitoring of extramedullary AML relapse
Hupe, H. C., Wienecke, C. P., Bartels, S., Schipper, E., Leßmann, J., Lasch, A., Bader, M., Gabdoulline, R. R., Neugebohren, M., Dammann, E., et al. (2025) · HemaSphere · doi:10.1002/hem3.70097 · Cited by 9
Forghani, S., Shahsavand, A., Samiee, R., Kharaghani, M., Kiumarsi, A., Sabet, F. M., Akbarzadeh, S., Fattahniya, S., Rostami, M., Rad, S., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01174-3 · Cited by 9
Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience
Ohtsu, A., Goto, K., & Yoshino, T. (2023) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.99.015 · Cited by 9
Self-citationNasu, M., Khadka, V. S., Jijiwa, M., Kobayashi, K., & Deng, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010371 · Cited by 9
Nakamura, Y., Olsen, S., Zhang, N. J., Liao, J., & Yoshino, T. (2022) · Current Oncology · doi:10.3390/curroncol29050277 · Cited by 9
Self-citationMatsubayashi, H., Todaka, A., Kawakami, T., Hamauchi, S., Yokota, T., Higashigawa, S., Kiyozumi, Y., Harada, R., Kado, N., Nishimura, S., et al. (2022) · Journal of Human Genetics · doi:10.1038/s10038-022-01097-y · Cited by 9
Self-citationRoma, C., Sacco, A., Forgione, L., Abate, R. E., Lambiase, M., Dotolo, S., Maiello, M. R., Frezzetti, D., Nasti, G., Morabito, A., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12081956 · Cited by 9
Hu, Q., Kimura, Y., Ikeda, S., Tanaka, Y., Nakanoko, T., Ota, M., Yoshizumi, T., Eto, M., & Oki, E. (2025) · BJC Reports · doi:10.1038/s44276-025-00158-x · Cited by 8
Self-citationFan, A., Yang, C., Fan, Y., Tian, L., Yang, Z., & Fan, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.051 · Cited by 8
Genomic profile of Chinese patients with endometrial carcinoma
Li, J., Li, X., Quan, C., Li, X., Wan, C., & Wu, X. (2023) · BMC Cancer · doi:10.1186/s12885-023-11382-4 · Cited by 8
Sudo, K., Nakamura, Y., Ueno, M., Furukawa, M., Mizuno, N., Kawamoto, Y., Okano, N., Umemoto, K., Asagi, A., Ozaka, M., et al. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02834-0 · Cited by 8
Self-citationCirculating tumor DNA: A new tool to predict recurrence and guide treatment of colorectal cancer
Quang, E. V., Gandini, A., Taly, V., Laurent‐Puig, P., Zaanan, A., & Taı̈eb, J. (2025) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2025.102611 · Cited by 9
Metadata
- Authors
- Nakamura, Y., Taniguchi, H., Ikeda, M., Bando, H., Kato, K., Morizane, C., Esaki, T., Komatsu, Y., Kawamoto, Y., Takahashi, N., Ueno, M., Kagawa, Y., Nishina, T., Kato, T., Yamamoto, Y., Furuse, J., Denda, T., Kawakami, H., Oki, E., Nakajima, T., Nishida, N., Yamaguchi, K., Yasui, H., Goto, M., Matsuhashi, N., Ohtsubo, K., Yamazaki, K., Tsuji, A., Okamoto, W., Tsuchihara, K., Yamanaka, T., Miki, I., Sakamoto, Y., Ichiki, H., Hata, M., Yamashita, R., Ohtsu, A., Odegaard, J. I., & Yoshino, T.
- Affiliations
- National Cancer Center Hospital East (JP)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Hokkaido University Hospital (JP)
- Saitama Cancer Center (JP)
- Kanagawa Cancer Center (JP)
- Kansai Rosai Hospital (JP)
- Shikoku Cancer Center (JP)
- Osaka National Hospital (JP)
- University of Tsukuba Hospital (JP)
- Kyorin University Hospital (JP)
- Chiba Cancer Center (JP)
- Kindai University Hospital (JP)
- Kyushu University (JP)
- St. Marianna University School of Medicine (JP)
- The University of Osaka (JP)
- The Cancer Institute Hospital (JP)
- Kobe Medical Center (JP)
- Osaka Medical and Pharmaceutical University Hospital (JP)
- Gifu University (JP)
- Kanazawa University (JP)
- Shizuoka Cancer Center (JP)
- Kagawa University Hospital (JP)
- Hiroshima University Hospital (JP)
- Guardant (United States) (US)
- Corresponding author
- Yoshino, Takayuki
- ORCID
- Nakamura, Yoshiaki
- Taniguchi, Hiroya
- Ikeda, Masafumi
- Bando, Hideaki
- Kato, Ken
- Morizane, Chigusa
- Esaki, Taito
- Komatsu, Yoshito
- Kawamoto, Yasuyuki
- Takahashi, Naoki
- Ueno, Makoto
- Kagawa, Yoshinori
- Nishina, Tomohiro
- Kato, Takeshi
- Yamamoto, Yoshiyuki
- Furuse, Junji
- Denda, Tadamichi
- Kawakami, Hisato
- Oki, Eiji
- Nakajima, Takako
- Nishida, Naohiro
- Yamaguchi, Kensei
- Yasui, Hisateru
- Goto, Masahiro
- Matsuhashi, Nobuhisa
- Ohtsubo, Koushiro
- Yamazaki, Kentaro
- Tsuji, Akihito
- Okamoto, Wataru
- Tsuchihara, Katsuya
- Yamanaka, Takeharu
- Sakamoto, Yasutoshi
- Ichiki, Hiroko
- Yamashita, Riu
- Ohtsu, Atsushi
- Odegaard, Justin I.
- Yoshino, Takayuki
- Venue
- Nature Medicine
- Published
- 2020-10-05
- Volume
- 26
- Issue
- 12
- Pages
- 1859-1864
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3089353724
- Cited by
- 373
- References
- 32
- Citations by year
- 2026: 41 · 2025: 57 · 2024: 60 · 2023: 71 · 2022: 73 · 2021: 67 · 2020: 3
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- circulating tumor DNA, liquid biopsy, advanced gastrointestinal cancer, clinical trial recruitment, clonal architecture, oncogenic drivers, precision medicine
- MeSH terms
- Circulating Tumor DNA, Adult, DNA, Neoplasm, Gastrointestinal Neoplasms, Genotype, Humans, Japan, Male, Middle Aged, Mutation, Biomarkers, Tumor, Precision Medicine, High-Throughput Nucleotide Sequencing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
