Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery
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The three initial HCC neoadjuvant studies demonstrate the utility of the window-of-opportunity setting and provide mechanistic insight because resected tumour tissue allows in-depth immune analysis instead of relying on scant on-treatment biopsies.
“These three initial studies highlight the utility of the neoadjuvant ‘window-of-opportunity’ setting and provide insight on the mechanisms of action of ICIs, given the potential to use resected tumour tissue for in-depth immune analysis rather than relying on scant on-treatment biopsy samples128.”
From Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024) · cites this paper as [128]
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- Authors
- Marron, T. U., Galsky, M. D., Taouli, B., Fiel, M. I., Ward, S., Kim, E., Yankelevitz, D., Doroshow, D., Guttman-Yassky, E., Ungar, B., Mehandru, S., Golas, B. J., Labow, D., Sfakianos, J., Nair, S. S., Chakravarty, D., Buckstein, M., Song, X., Kenigsberg, E., Gnjatic, S., Brown, B. D., Sparano, J., Tewari, A., Schwartz, M., Bhardwaj, N., & Merad, M.
- Affiliations
- Tisch Cancer Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Marron, Thomas U.
- ORCID
- Marron, Thomas U.
- Galsky, Matthew D.
- Taouli, Bachir
- Fiel, Maria Isabel
- Ward, Stephen
- Kim, Edward
- Yankelevitz, David
- Doroshow, Deborah
- Guttman-Yassky, Emma
- Ungar, Benjamin
- Mehandru, Saurabh
- Sfakianos, John
- Nair, Sujit S.
- Buckstein, Michael
- Song, Xiaoyu
- Gnjatic, Sacha
- Brown, Brian D.
- Sparano, Joseph
- Tewari, Ashutosh
- Bhardwaj, Nina
- Merad, Miriam
- Venue
- Nature Medicine
- Published
- 2022-03-28
- Volume
- 28
- Issue
- 4
- Pages
- 626-629
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC9901535
- OpenAlex
- W4220731098
- Cited by
- 30
- References
- 25
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 2
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-07-18)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA254104)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- neoadjuvant therapy, window-of-opportunity trial, anticancer drug discovery, mechanism of action, trial design, sample collection, sample analysis
- MeSH terms
- Antineoplastic Agents, Breast Neoplasms, Clinical Trials as Topic, Female, Humans, Neoplasms, Neoadjuvant Therapy, Drug Discovery
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