Emerging diagnostics and therapeutics for Alzheimer disease

Lecanemab in early Alzheimer's disease

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212948 · Cited by 5,678

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., et al. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00249-8 · Cited by 5,575

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059

HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease

Esandi, J., Renault, P., Capilla-López, M. D., Blanch, R., Edo, Á., Ramirez-Gómez, D., Bosch, A., Almolda, B., Saura, C. A., Giraldo, J., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117815

Traditional Therapies for Alzheimer’s Disease

Gobinath, M., Dwarampudi, L. P., Roychowdhury, P., Yamuna, K., Dutta, S., & Shanmugam, R. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_10

Evaluating roles of plasma glial fibrillary acidic protein as Alzheimer's disease biomarker in real-world multi-center memory clinics in Thailand

Taweephol, T., Pongpitakmetha, T., Booncharoen, K., Khieukhajee, J., Luechaipanit, W., Haethaisong, T., Chongsuksantikul, A., Likitjaroen, Y., & Thanapornsangsuth, P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251316546

Influence of apolipoprotein E genotype on the proteomic profile in cerebral microdialysis after human severe traumatic brain injury: a prospective observational study

Lindblad, C., Klang, A., Bark, D., Bellotti, C., Hånell, A., Enblad, P., Lewén, A., & Rostami, E. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf096 · Cited by 1

Synthesis and Evaluation of Indanone-Phenothiazine Analogues as Potential Dual-Inhibitors for Acetylcholinesterase and Tau AggregationPreprint

Hu, Q., Xu, K. L., Ran, Q., Zhang, W., Gan, C., Fang, Q., & Hui, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5186865

Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer’s disease micePreprint

Byron, N., McAlinden, N., Pisano, F., Pisanello, M., Ferreira, J., Montinaro, C., Mathieson, K., Vittorio, M. D., Pisanello, F., & Sakata, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.08.647900

Chalcogenapyrylium-engineered D-π-A probe for enhanced optoacoustic imaging of amyloid-β plaques

Li, J., Wang, T., Zhang, X., Su, X., & Liu, N. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138086

Accelerating development of vaccines for prevention and control of Alzheimer's disease

Koff, W. C., & Holtzman, D. M. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127410

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Futai, E., Shiina, M., Dai, Y., Daoudi, K., Hidaka, M., & Ogawa, T. (2025) · Journal of Visualized Experiments · doi:10.3791/67733

EVALUATION OF THE LEVEL OF KNOWLEDGE ABOUT ALZHEIMER DISEASE IN THE TEKIRDAĞ PROVINCE, TURKEY: A CROSS-SECTIONAL STUDY

Dilek, F., & Ünal, A. (2025) · The Turkish Journal of Geriatrics · doi:10.29400/tjgeri.2025.439

The Protective Mechanism of ApoE3 R136S in Alzheimer’s Disease: A New Hope for Neurodegeneration

Luo, R., & Guo, K. (2025) · Phenomics · doi:10.1007/s43657-025-00253-6

Gut Barrier Permeability, Microbiota, and Brain Health

Madison, A. A., Duff, A. F., & Bailey, M. T. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.17

Interpretable AI Driven Prognostic Tool for Predicting β-Amyloid Plaque Accumulation

Xu, H., Wang, Y., Liao, K.-Y., Hsin, Y. L., Liu, W., & Initiative, A. D. N. (2025) · Communications in computer and information science · doi:10.1007/978-3-031-94950-0_23

The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease

Zhou, S.-Y., Lin, H., Tang, J., Yao, Q.-Y., Hu, J.-W., Long, W.-J., Dai, W.-Z., Ma, T., & Zhu, X. (2025) · Current Alzheimer Research · doi:10.2174/0115672050397092250823195514

Design and protocol of a pragmatic clinical trial to improve cognitive impairment detection in primary care

Crouse, B. K., Rossom, R. C., Crain, A. L., O’Connor, P. J., JaKa, M. M., Maciosek, M. V., Appana, D., Sharma, R., Gustafson, S. K., Werner, A. M., et al. (2025) · Contemporary Clinical Trials · doi:10.1016/j.cct.2025.108080

Long-term locus coeruleus stimulation exacerbates tau pathology in PS19 mice

Nong, Y., Wellman, S. M., Zhang, H., Liu, Y., Argyrousi, E. K., Arancio, O., & Wang, Q. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261468577

Cold Atmospheric Plasma for Alzheimer’s diseasePreprint

Chen, X., Yu, Z. J., Du, C., Huang, Y., Chen, Z., Xu, Z., & Chen, Z. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.07.687156

TEMPOL alleviated tau pathology and cognitive deficits induced by P301S-tau

Li, X., Liu, R., He, Y., Yang, X., Li, T., & Feng, Y. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138465

Ultra-large stokes shift probe enables SIM super-resolution tracking of lysosomal acidification impairment in Aβ trafficking dysregulation during Alzheimer's disease

Liu, Y., Zhang, C., Wang, X., Shao, Y., Cai, X., Liu, H., Zhu, H., Liu, X., Qian, Y., & Wang, X. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118284

Additional file 1 of The criteria used to rule out mild cognitive impairment impact dementia incidence rates in subjective cognitive decline

Whitfield, T. J., Chouliaras, L., Morrell, R., Rubio, D., Radford, D., Marchant, N. L., & Walker, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26129662

Additional file 14 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711651

Additional file 4 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711621

Additional file 1 of Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy

Yang, Y., Murzin, A. G., Peak-Chew, S., Franco, C., Garringer, H. J., Newell, K. L., Ghetti, B. F., Goedert, M., & Scheres, S. H. W. (2024) · Figshare · doi:10.6084/m9.figshare.26649156

Additional file 1 of Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank

Wang, X., Shi, Z., Qiu, Y., Sun, D., & Zhou, H. (2024) · Figshare · doi:10.6084/m9.figshare.26719356

Additional file 10 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711639

Additional file 15 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711654

Additional file 5 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711624

Additional file 21 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711672

Additional file 9 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711636

Additional file 11 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711642

Additional file 16 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711657

Additional file 18 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711663

Additional file 7 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711630

Additional file 13 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711648

Additional file 2 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25687615

Additional file 2 of Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy

Yang, Y., Murzin, A. G., Peak-Chew, S., Franco, C., Garringer, H. J., Newell, K. L., Ghetti, B. F., Goedert, M., & Scheres, S. H. W. (2024) · Figshare · doi:10.6084/m9.figshare.26649159

Additional file 8 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711633

Additional file 12 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711645

Additional file 1 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25687445

Additional file 3 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711618

Additional file 20 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711669

Additional file 6 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711627

Additional file 19 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711666

Additional file 17 of Adaptive immune changes associate with clinical progression of Alzheimer’s disease

van Olst, L., Kamermans, A., Halters, S., van der Pol, S. M. A., Rodríguez, E., Verberk, I. M. W., Verberk, S. G. S., Wessels, D. W. R., Rodriguez-Mogeda, C., Verhoeff, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711660

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activity, Therapeutic Potentials, and Functional Foods of Coccinia grandis (L.) Voigt: An Updated Review

Siam, N. H., & Snigdha, N. N. (2025) · Frontiers in Bioscience-Elite · doi:10.31083/fbe37698

Early Detection of Alzheimer’s Disease Using Data-Driven Classification Models

Ganesh, P., Sowmya, G., Rao, K. N., & Bikku, T. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-032-14044-9_26

ApoE and COVID-19 Risk and Long-Term Burden

Tavares-Júnior, J. W. L., Ciurleo, G. C. V., Oriá, R. B., & Braga‐Neto, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_56-1

Ultrasound-Mediated Gene Therapy in Alzheimer’s Disease Validated through In Vivo PET ImagingPreprint

Guo, Y., Foiret, J. L., Ajenjo, J., Malek, R. S., Zhang, N., Seo, J. W., Wang, J., Jan, B. L., Raie, M. N., Tumbale, S. K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.02.703398

The growing burden of Alzheimer’s Disease and other dementias in China: Lessons for an aging society

Wang, C., Xin, T., Zhong, W., Tian, Q., & Chen, L. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106165

Global, regional, and national burden of age-related hearing loss and Alzheimer’s disease, 1990–2021, with projections to 2040: A global burden of disease study

Liu, D., Zhang, Y., & Zhang, S. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106170

A Smart Dicyano-Based Fluorescent Probe for In Vivo Amyloid-β Visualization to Illuminate Alzheimer’s Disease

Li, X., Yang, H., Liang, Z., Zeng, A., Zou, Y., Dai, J., Zhu, B., Yang, J., Zhang, L. G., & Wang, J. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01177

Design strategies of self-assembled nanomaterials enabled by natural bioactive compounds for precision and multi-mechanism therapy of Alzheimer's disease

Zhao, T., Ma, D., Sun, J., Li, S., & Yang, H. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.174543

Label-free multispectral fluorescence lifetime imaging enables non-invasive diagnosis of Alzheimer’s disease in cerebral organoids

Son, B., Han, J., Kang, J., Jeong, I., Han, D., Kwon, S., Jung, A., Yoo, H., Gweon, B., & Park, H. H. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103020

Optimal control of Alzheimer’s disease model via multi-target combination therapy

Dong, M., Guo, Z., Zhang, Y., Luo, J., & Zhang, J. (2026) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2026.112425

Peripheral immune profiling in frontotemporal dementia

Gamez, N., Eid, A. M., Pascual, B., Li, D., Wang, Y., Masdeu, J. C., Appel, S. H., & Faridar, A. (2026) · Brain Communications · doi:10.1093/braincomms/fcag089

A unique compound 3c targets GSK-3β and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases Aβ accumulation and ABTS•+, and enhances zebrafish motility

Zhang, J., Li, Y., Li, Y.-P., Xun, Q., Ma, Y., & Shi, X.-L. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109760

Exosomes as vectors across the blood–brain barrier in neurological research

Singh, Y., Shukla, R., Vishaka, K., Banerjee, A., Patel, D., Ojha, A., & Singh, R. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36390-0.00017-8

Effects of APOE ε4 and amyloid pathology on longitudinal tau biomarkers, neurodegeneration, and cognitive decline in mild cognitive impairment

Wang, X., Zhang, C., Liu, X., Tai, Y., Ma, G., Kong, M., Ba, M., & Initiative, A. D. N. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261435429

Synaptic plasticity in a memory circuit : physiological and pathophysiological role of the amyloid precursor protein

Moreira-de-Sá, A. (2024) · theses.fr (ABES) · doi:10.70675/3e418ab2ze9a3z43e4z9d87ze5870aefddac

N-Terminal Truncation and Cholesterol-Induced Suppression of Fluctuations Impair p3 (Aβ 17–42 ) Adsorption onto Lipid Bilayers

Zhou, H., Zhu, J., Cao, Y., & Liang, Q. (2026) · Langmuir · doi:10.1021/acs.langmuir.6c00216 · Cited by 1

Virtual reality-based training in patients with alzheimer's disease: A systematic review and meta-analysis

Wang, J., Wu, C., Zhu, K., Qi, X., & Chen, G. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100590

ApoE and COVID-19 Risk and Long-Term Burden

Tavares-Júnior, J. W. L., Ciurleo, G. C. V., Oriá, R. B., & Braga‐Neto, P. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_56

Design and synthesis of piperazine-based 3,5-disubstituted-1,2,4-oxadiazole derivatives as dual AChE and BChE inhibitors: In vitro and in silico studies

Faydalı, N., Erol, M., Temiz‐Arpacı, Ö., Küçükoğlu, K., Dilek, E., & Muhammed, M. T. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146605

Machine Learning Approach to Predict Cognitive Domains with Process Parameters in Digital Drawing TasksPreprint

Mychajliw, C., Wortha, F., Suenkel, U., Eschweiler, G. W., Dawidowsky, K., von Thaler, A., Fallgatter, A. J., Maetzler, W., Metzger, F. G., & Holz, H. (2026) · Research Square · doi:10.21203/rs.3.rs-9453201/v1

Affinity selection-mass spectrometry discovery of small molecule ILT3 (LILRB4) binders and pharmacological characterization in Alzheimer's disease models

Abdel‐Rahman, S. A., Murugan, N. A., & Gabr, M. T. (2026) · European Journal of Medicinal Chemistry Reports · doi:10.64898/2026.06.05.730337

AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologyPreprint

Abdel‐Rahman, S. A., & Gabr, M. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.12.731845

Peptide vaccination for Alzheimer's disease: Immunological foundations, therapeutic potential, and translational barriers

Chen, H., Lin, Y. Y., Kang, D., & Zhao, T. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261462546

Elucidating Molecular Features of White Matter Hyperintensities in Alzheimer’s Disease through Multimodal Imaging and SHAP AnalysisPreprint

Scott, C. F., Marshall, C. R., Migas, L. G., Tideman, L. E. M., Colley, M. E., Djambazova, K. V., Romero‐Fernandez, W., Schrag, M., de Plas, R. V., & Spraggins, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.18.733283

Sequential targeting nanochaperone disrupts positive feedback loop of mitochondrial dysfunction for Alzheimer's disease therapy

Hu, H., Zhao, S., Xu, L., Ma, Z., Ma, R., Huang, F., & Shi, L. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124408

Carboxy terminal of ECRG4 is a potential initiator for amyloid pathology in Alzheimer's disease through interacting with APP intracellular domain

Chung, M. L. K., Takeda, S., Ryu, J., Murayama, S., Koshimizu, U., & Kondo, T. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261462890

Hunting for an Antigen: Humoral Immunity in Alzheimer’s Disease

Delgado, A. M., Greer, B. D., Maul, R. W., & Gearhart, P. J. (2026) · Cells · doi:10.3390/cells15131227

Alzheimer’s disease risk prediction via perceptual deformable attention generative adversarial network with large foundation models

Xing, Z., Liu, Z., Zhang, D.-F., Xie, K., Fang, J., Bi, X.-A., & Liu, T. (2026) · Medical Image Analysis · doi:10.1016/j.media.2026.104225

Neuroprotective mechanism of Ribisin A on Aβ25–35-induced PC12 cell damage model

Du, X., Bao, M., Li, Y., Ding, J., Zhang, Z., Chen, H., & Liu, Y. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103825

Therapeutic Potential of Jiedu Yizhi Formula for Alzheimer’s Disease: A Randomized Controlled Trial

Li, Y.-Q., Chen, D.-X., Zhu, X.-T., Li, W., Jia-li, W. U., Fang, L.-M., & Li, M. (2026) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-026-3944-z

Advances of amyloid β and tau protein detection in Alzheimer's disease: The role of electrochemical biosensors

Nemati, S. S., Nilghaz, A., & Dehghan, G. (2026) · Results in Chemistry · doi:10.1016/j.rechem.2026.103735

SHED-derived small extracellular vesicles as potential neuro-immune modulators in Alzheimer's disease

Ijaz, A., Phothichailert, S., Fitri, A. R., Zohaib, S., Suwittayarak, R., Kornsuthisopon, C., Samaranayake, L. P., Egusa, H., & Osathanon, T. (2026) · Journal of Oral Biosciences · doi:10.1016/j.job.2026.100811

Near-Infrared Imaging of Senescence-Associated β-Galactosidase Enables Discovery of a Glycerol-3-Phosphate Dehydrogenase 2-Regulated Neuroprotective Pathway in Alzheimer’s Disease

Xu, C., Liang, H., Chen, Y., Wang, X., Selvan, G. T., Wang, K., Zhu, Q., Xing, Y., Dou, K., Yu, F., et al. (2026) · ACS Sensors · doi:10.1021/acssensors.6c02748

Linking behavioral and psychological symptoms to nutritional status in Alzheimer's disease: Clinical correlations and implications

Nie, W., Liang, Z., Fu, Q., Tan, Y., Wang, L., Wu, W., & Liang, J. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.107768

Integrative transcriptomic analysis reveals KLHL2 downregulation as a potential driver of microglial inflammation in Alzheimer’s disease via the WNK3/JNK/c-Jun axis

Yang, Y., Dai, C., Xu, Z., Zhuo, L., Xiang, K., Lin, X., Sun, J., Liu, J., & Tong, Q. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e01069

Isolation, in vitro acetylcholinesterase inhibitory activity, molecular docking, and in silico ADME analysis of compounds from Cadaba farinosa roots

Tini, M. I., Idrissa, S., Magid, A. A., Taleb, M., & Voutquenne‐Nazabadioko, L. (2026) · Phytochemistry Letters · doi:10.1016/j.phytol.2026.104254

Validation of plasma core biomarkers of Alzheimer's disease: A multicenter study in usual practice conditions

Sánchez‐Soblechero, A., Villarejo‐Galende, A., Carreras, M. T., García, Á. B., Puertas, C., Bullido, Y. F., Vieira, A., Gundín, I., Blanco-Palmero, V. A., González‐Sánchez, M., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261487171

Bioinformatics‐Driven Discovery of A β ‐Targeted Therapeutics and Diagnostic Biomarkers for Alzheimer′s Disease

Li, X., Liu, X., Xinran, S. O. N. G., Zhou, Y., Yang, D., Wang, Y., Mao, S., Rang, X., Hong, X., Wang, X., et al. (2026) · BioMed Research International · doi:10.1155/bmri/8975137

Blood biomarkers and artificial intelligence: toward precision medicine in Alzheimer’s disease

Xu, L., Tu, J., Zhang, J., Zhang, C., & Sun, Y. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1937244

Targeting neuronal injury with intranasal Arc-engineered exosomes rescues cognitive deficits in Alzheimer's disease via the mTOR-autophagy pathway

Sun, C., Sha, S., Kang, J., Gao, X., Cheng, X., Huo, X., Hang, Z., Zhou, L., Li, Y., Xing, C., et al. (2026) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2026.103028

Therapeutic potential of proline-rich peptide-1 (PRP-1) in counteracting amyloid-β-mediated cortical and hippocampal neurodegeneration in a rat model

Stepanyan, H., Ghorbani, H., Poghosyan, М. V., Danielyan, M., Minasyan, A., Hunanyan, A. S., & Hunanyan, N. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.09.043

QCM-D Reveals Parallel Adsorption Pathways Governing Amyloid-β Binding to LRP-1

Lewis, G., Tan, E., Myung, Y., Fan, S., & Johal, M. S. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c04707

Simultaneous Visualization of Labile Ferrous Iron Pool and Biothiols Reveals Divergent Pathological Trajectories in Ferroptosis and Alzheimer’s Disease

Yin, G., Tan, W., Wang, D., He, Z., 窦彩霞, Wang, H., Lu, Q., 钟根深, Du, F., & Yin, P. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c05055

Hippocampal and hypothalamic cell-type specific mechanisms underlying nutritional and metabolic modulation of Alzheimer’s disease

Ding, J., Samvelian, D. A., Ying, Z., Diamante, G., Ahn, I. S., Palafox-Sánchez, V., Wang, S. S.-M., Gómez‐Pinilla, F., & Yang, X. (2026) · iScience · doi:10.1016/j.isci.2026.117920

The Utility of Tactile and Learning-Recognition Tasks to Detect Mild Cognitive Impairment in Older Adults

Xu, J., Zhou, F., Fu, Y., Sun, Z., Sun, Y., Zhu, X., Pan, S., Jiang, K., & Tong, Z. (2026) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000430

Purine metabolism disruption links pathology and cognitive decline in Alzheimer’s disease

Qian, X., Wang, Z., Chen, S., Xue, Y., Yang, Y., Cui, P., Zhang, M., & Tang, H. (2026) · JCI Insight · doi:10.1172/jci.insight.205511

Breast carcinoma amplified sequence 2 rescues adult hippocampal neurogenesis and cognitive deficits in Alzheimer’s disease via regulating BDNF/TrkB signaling

Ma, H., Liu, C., Liu, W., Liu, J., Hou, Y., Qiao, S., Wang, Y., & Wang, P. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03947-z

Harnessing Nanozyme Catalytic Activities for Multi-Target Intervention in Neurodegenerative Pathology

Wang, Y., Cheng, J., Liu, T., Li, S., Wang, Q., Shao, K., Yang, G., & Li, P. (2026) · Nanomaterials · doi:10.3390/nano16211355

Multiplex Plasma Proteomics for Biologically Layered Dementia Triage

Ji, F. (2026) · Neuropharmacology and Therapy · doi:10.15212/npt-2026-0021

Biomarkers for Alzheimer’s disease—preparing for a new era of disease-modifying therapies

Zetterberg, H., & Bendlin, B. B. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0721-9 · Cited by 408

Perspectivas biotecnológicas en el diagnóstico y la terapia de la enfermedad de Alzheimer

Suárez, A. H. (2021) · Hispana

Recent advances in pre-clinical diagnosis of Alzheimer’s disease

Zhou, J., Benoit, M., & Sharoar, M. G. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00733-4 · Cited by 14

Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention

Mahaman, Y. A. R., Embaye, K. S., Huang, F., Li, L., Zhu, F., Wang, J.-Z., Liu, R., Feng, J., & Wang, X. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101544 · Cited by 149

Morbus Alzheimer – State of the art und Blick in die Zukunft

Winkler, D. T., & Leyhe, T. (2018) · Therapeutische Umschau · doi:10.1024/0040-5930/a001020 · Cited by 2