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Computational methods for single-cell omics across modalities
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“Increasingly sophisticated experimental approaches have allowed discovery of significant diversity and functional heterogeneity within the fibroblast population during organ fibrosis22–25 .”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [24]
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“Correlated transcriptomic and epigenomic signatures can allow computational methods to integrate independent datasets despite batch effects and systematic differences (Efremova and Teichmann, 2020).”
From Single-Cell Sequencing of Brain Cell Transcriptomes and Epigenomes (2021) · cites this paper as Efremova and Teichmann, 2020
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Metadata
- Authors
- Efremova, M., & Teichmann, S. A.
- Affiliations
- Wellcome Sanger Institute (GB)
- University of Cambridge (GB)
- Corresponding author
- Teichmann, Sarah A.
- Venue
- Nature Methods
- Published
- 2020-01
- Volume
- 17
- Issue
- 1
- Pages
- 14-17
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2998127407
- Cited by
- 201
- References
- 31
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 28 · 2023: 41 · 2022: 28 · 2021: 48 · 2020: 22
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- single-cell omics, multi-omics integration, single-cell genomics, single-cell epigenomics, single-cell transcriptomics, single-cell proteomics, gene regulatory networks, signaling networks, cell identity, computational methods
- MeSH terms
- Epigenome, Humans, Computational Biology, Proteome, Gene Expression Profiling, Gene Regulatory Networks, Metabolic Networks and Pathways, Single-Cell Analysis
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