The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli
Open accessAbstract
Midbrain dopamine neurons are well known for their role in reward-based reinforcement learning. We found that the activity of dopamine axons in the posterior tail of the striatum (TS) scaled with the novelty and intensity of external stimuli, but did not encode reward value. We demonstrated that the ablation of TS-projecting dopamine neurons specifically inhibited avoidance of novel or high-intensity stimuli without affecting animals’ initial avoidance responses, suggesting a role in reinforcement rather than simply in avoidance itself. Furthermore, we found that animals avoided optogenetic activation of dopamine axons in TS during a choice task and that this stimulation could partially reinstate avoidance of a familiar object. These results suggest that TS-projecting dopamine neurons reinforce avoidance of threatening stimuli. More generally, our results indicate that there are at least two axes of reinforcement learning using dopamine in the striatum: one based on value and one based on external threat. Menegas et al. show that dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli. Their results indicate that there are two axes of reinforcement learning using dopamine, the value axis and the threat axis.
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McCutcheon, R. A., Reis Marques, T., & Howes, O. D. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3360 · Cited by 1,481
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Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
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Dopamine and Cognitive Control in Prefrontal Cortex
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Metadata
- Authors
- Menegas, W., Akiti, K., Amo, R., Uchida, N., & Watabe-Uchida, M.
- Venue
- Nature Neuroscience
- Published
- 2018-09-03
- Volume
- 21
- Issue
- 10
- Pages
- 1421-1430
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2888695486
- Cited by
- 382
- References
- 68
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- green
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