Revisiting atherosclerosis and dementia

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480 · see citing works

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Iturria-Medina, Y., Sotero, R. C., Toussaint, P. J., Mateos-Pérez, J. M., Evans, A. C., Initiative, T. A. D. N., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11934 · Cited by 1,202 · see citing works

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173 · see citing works

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Preische, O., Schultz, S. A., Apel, A., Kuhle, J., Kaeser, S. A., Barro, C., Gräber, S., Kuder-Buletta, E., LaFougere, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0304-3 · Cited by 927 · see citing works

Vascular Cognitive Impairment and Dementia

Iadecola, C., Duering, M., Hachinski, V., Joutel, A., Pendlebury, S. T., Schneider, J. A., & Dichgans, M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.034 · Cited by 831 · see citing works

Neurovascular and Cognitive Dysfunction in Hypertension

Iadecola, C., & Gottesman, R. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313260 · Cited by 518 · see citing works

Preventing dementia by preventing stroke: The Berlin Manifesto

Hachinski, V., Einhäupl, K. M., Ganten, D., Alladi, S., Brayne, C., Stephan, B. C. M., Sweeney, M. D., Zloković, B. V., Iturria‐Medina, Y., Iadecola, C., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.001 · Cited by 314 · see citing works

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

Roher, A. E., Esh, C. L., Kokjohn, T. A., Kalback, W. M., Luehrs, D. C., Seward, J. D., Sue, L. I., & Beach, T. G. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095973.42032.44 · Cited by 280 · see citing works

Dietary salt promotes cognitive impairment through tau phosphorylation

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. (2019) · Nature · doi:10.1038/s41586-019-1688-z · Cited by 236 · see citing works

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Wingo, A. P., Fan, W., Duong, D. M., Gerasimov, E. S., Dammer, E. B., Liu, Y., Harerimana, N. V., White, B., Thambisetty, M., Troncoso, J. C., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0635-5 · Cited by 161 · see citing works

Cerebrovascular Alterations in Alzheimer Disease

Iadecola, C., & Gottesman, R. F. (2018) · Circulation Research · doi:10.1161/circresaha.118.313400 · Cited by 135 · see citing works

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

Tan, C., Lu, N., Wang, C., Chen, D.-Y., Sun, N.-H., Lyu, H., Körbelin, J., Shi, W., Fukunaga, K., Lu, Y., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.036 · Cited by 126 · see citing works

Midlife Atherosclerosis and Development of Alzheimer or Vascular Dementia

Gustavsson, A., van Westen, D., Stomrud, E., Engström, G., Nägga, K., & Hansson, O. (2019) · Annals of Neurology · doi:10.1002/ana.25645 · Cited by 87 · see citing works

Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition

Gottesman, R. F., Mosley, T. H., Knopman, D. S., Hao, Q., Wong, D. F., Wagenknecht, L. E., Hughes, T. M., Qiao, Y., Dearborn, J. L., & Wasserman, B. A. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.4339 · Cited by 46 · see citing works

Neuroprotective effect of SGLT2 inhibitors.

Pawlos, A., Broncel, M., Woźniak, E., & Gorzelak-Pabiś, P. (2021) · Molecules · doi:10.3390/molecules26237213 · Cited by 304 · see citing works

There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness

Makover, M. E., Shapiro, M. D., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100371 · Cited by 133 · see citing works

Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1

March-Diaz, R., Lara-Ureña, N., Romero-Molina, C., Heras-Garvin, A., Ortega-de San Luis, C., Alvarez-Vergara, M. I., Sanchez-Garcia, M. A., Sanchez-Mejias, E., Davila, J. C., Rosales-Nieves, A. E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00054-2 · Cited by 125 · see citing works

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

Duong, M. T., Nasrallah, I. M., Wolk, D. A., Chang, C. C. Y., & Chang, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.647990 · Cited by 106 · see citing works

A Review on Joint Carotid Intima-Media Thickness and Plaque Area Measurement in Ultrasound for Cardiovascular/Stroke Risk Monitoring: Artificial Intelligence Framework

Biswas, M., Saba, L., Omerzu, T., Johri, A. M., Khanna, N. N., Višković, K., Mavrogeni, S. I., Laird, J. R., Pareek, G., Miner, M. M., et al. (2021) · Journal of Imaging Informatics in Medicine · doi:10.1007/s10278-021-00461-2 · Cited by 67 · see citing works

Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine

Wang, D., Zhang, L., Huang, J., Himabindu, K., Tewari, D., Horbańczuk, J. O., Xu, S., Chen, Z., & Atanasov, A. G. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.11.024 · Cited by 55 · see citing works

Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis

Wu, J., Xiong, Y., Xia, X., Orsini, N., Qiu, C., Kivipelto, M., Rizzuto, D., & Wang, R. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101788 · Cited by 53 · see citing works

High coffee consumption, brain volume and risk of dementia and stroke

Pham, K., Mulugeta, A., Zhou, A., O'Brien, J. T., Llewellyn, D. J., & Hyppönen, E. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1945858 · Cited by 36 · see citing works

Assessing cerebral arterial pulse wave velocity using 4D flow MRI

Björnfot, C., Garpebring, A., Qvarlander, S., Malm, J., Eklund, A., & Wåhlin, A. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211008744 · Cited by 33 · see citing works

Antioxidant potentials of furanodihydrobenzoxanthones from Artocarpus elasticus and their protection against oxLDL induced injury in SH-SY5Y cells

Baiseitova, A., Shah, A. B., Khan, A. M., Idrees, M., Kim, J. H., Lee, Y. H., Kong, I., & Park, K. H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115278 · Cited by 27 · see citing works

SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis induced by homocysteine

Xie, L., Ding, N., Zhang, H., Liu, K., Xiong, J., Ma, S., Yang, A., Zhang, H., & Jiang, Y. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.105974 · Cited by 26 · see citing works

The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia

Zhang, H., Zhou, L., Yang, S., Dong, M., Chen, L., Lu, Y.-L., Zhang, L., Zhang, L., Chu, Y., Xu, L., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.04.009 · Cited by 21 · see citing works

Macrophages, Metabolites, and Nucleosomes: Chromatin at the Intersection between Aging and Inflammation

Church, M. C., Workman, J. L., & Suganuma, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910274 · Cited by 19 · see citing works

Association of Cardiovascular Health with Cognitive Function in US Older Adults: A Population-Based Cross-Sectional Study

Shen, R., Guo, X., Zou, T., & Ma, L. (2023) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000534923 · Cited by 9 · see citing works

Incident dementia in ischaemic stroke patients with early cardiac complications: A propensity-score matched cohort study

Bucci, T., Choi, S. E., Tsang, C. T., Yiu, K.-H., Buckley, B., Pignatelli, P., Scheitz, J., Lip, G., & Abdul-Rahim, A. (2024) · European Stroke Journal · doi:10.1177/23969873241293573 · Cited by 11 · see citing works

Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study

Si, Q., Teng, Y., Liu, C., Yuan, W., Fan, X., Zhang, X., Zhang, Z., Li, M. L., Liu, Q., Wang, P., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3570 · Cited by 8 · see citing works

Mechanistic exploration of the shenlian formula in the suppression of atherosclerosis progression via network pharmacology and in vivo experimental validation

Xing-xing, C., Ri-jin, H., Wang, X., Cai-ying, Y., Qing, Y., Chen, Y., Li, Q., Zhu, X., Lihong, Y., Cheng, L., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118347 · Cited by 7 · see citing works

Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms

Gainey, M., Niles, A., Nathaniel, S. I., Goodwin, R. L., Roley, L. T., Win, O., Nathaniel, T. I., & Imeh‐Nathaniel, A. (2024) · Geriatric Nursing · doi:10.1016/j.gerinurse.2024.04.019 · Cited by 6 · see citing works

Association of the atherogenic index of plasma with cognitive function and oxidative stress: A population-based study

Zhang, H., Shi, L., Tian, N., Zhu, M., Liu, C., Hou, T., & Du, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251334826 · Cited by 6 · see citing works

Estimation of Machine Learning–Based Models to Predict Dementia Risk in Patients With Atherosclerotic Cardiovascular Diseases: UK Biobank Study

Gu, Z. N., Liu, S., Ma, H., Long, Y., Jiao, X., Gao, X., Du, B., Bi, X., & Shi, X. (2025) · JMIR Aging · doi:10.2196/64148 · Cited by 5 · see citing works

Editorial: Epidemiology and clinical researches in atherosclerosis and cardiovascular disease

Gao, D., Cai, Y. S., Pan, Y., Ma, Q., & Xie, W. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1212269 · Cited by 4 · see citing works

Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response

Jain, S., Swain, S., Das, L., Swain, S., Giri, L., Kondapi, A. K., & Unni, H. N. (2020) · Bioengineering · doi:10.3390/bioengineering7040162 · Cited by 3 · see citing works

[Relationship between Oral Microbiota and Alzheimer's Disease].

Li, Y.-C., Liu, Y., Chen, F., Chu, M., & Chen, X.-C. (2022) · PubMed Central · doi:10.12182/20220360304 · Cited by 3 · see citing works

Improving mouse models for the study of Alzheimer's disease

Reagan, A. M., Onos, K. D., Heuer, S. E., Sasner, M., & Howell, G. R. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2021.12.005 · Cited by 3 · see citing works

Dementia risk in patients with heart disease and depression

Denisenko, D., Ekong, G. J., & Spotts, H. E. (2023) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2023-0024 · Cited by 3 · see citing works

Connections Between Hypertension, Atherosclerosis, Acute Myocardial Infarction, and Risk of Dementia

Stern, A., & Frishman, W. H. (2024) · Cardiology in Review · doi:10.1097/crd.0000000000000739 · Cited by 3 · see citing works

Alzheimer’s Disease

Pinessi, L., & Longhi, E. V. (2023) · Springer eBooks · doi:10.1007/978-3-031-31307-3_24 · Cited by 1 · see citing works

Towards a Multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating Evidence from a Critical Review into a Model for Future Research

Pinto, J. O., Peixoto, B., Dores, A. R., & Barbosa, F. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16070363 · Cited by 1 · see citing works

SGLT2 inhibitors - a breakthrough in treatment of heart failure and their multipotential beneficial role in cardiology, diabetology, nephrology and neurology

Bogowska, M., Berner, A., MARCZYK, K., MATYJA, K., OLSZEWSKA, A., PĘKAŁA, M., Polak, P., POLASZEK, M., Stelmaszak, K., & Stencel, K. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.38.01.013 · Cited by 1 · see citing works

Identifying modifiable factors associated with neuroimaging markers of brain health

Huang, L., Fu, Y., Zhang, Y., Hu, H., Ma, L., Ge, Y., Zhao, Y., Zhang, Y.-R., Chen, S., Feng, J., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70057 · Cited by 1 · see citing works

Estimation of Machine Learning-Based Models to Predict 5-Year or 10-Year Risk of Dementia in Patients with Atherosclerotic Cardiovascular Diseases: A UK Biobank StudyPreprint

Gu, Z., Liu, S., Ma, H., Jiao, X., Gao, X., Bi, X., Du, B., & Shi, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4823584

Consumption of coffee and tea and the risk of developing neurodegenerative diseases: a cohort study in the UK biobank

Lin, Y., Shi, Y., Chen, L., Chen, Z., Zhong, H., Zhong, Y., Zeng, R., Chen, X., Lin, F., & Cai, G. (2026) · Nutrition Journal · doi:10.1186/s12937-026-01291-0

Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of aging cohort

Dolan, H., Crain, B. J., Troncoso, J. C., Resnick, S. M., Zonderman, A. B., & O’Brien, R. (2010) · Annals of Neurology · doi:10.1002/ana.22055 · Cited by 232 · see citing works

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Wingo, A. P., Fan, W., Duong, D. M., Gerasimov, E. S., Dammer, E. B., Liu, Y., Harerimana, N. V., White, B., Thambisetty, M., Troncoso, J. C., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0635-5 · Cited by 161 · see citing works

S3‐01‐02: Atherosclerosis, aging, dementia and Alzheimer's disease

O’Brien, R. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.2358

Atherosclerotic patients with dementia show poorer long-term survival after carotid endarterectomy and increased markers of coagulation, epithelial-to-mesenchymal transition, and inflammation

Stoisavljevic, S., Wadén, K., Buckler, A. J., Lengquist, M., Roy, J., Vukojević, V. B., Bogdanović, N., Marlevi, D., & Matic, L. P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118368

Atherosclerosis and risk for dementia

van Oijen, M., de Jong, F. J., Witteman, J. C. M., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2007) · Annals of Neurology · doi:10.1002/ana.21073 · Cited by 312 · see citing works