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Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

Gerrits, Emma, Giannini, Lucia A. A., Brouwer, Nieske, Melhem, Shamiram, Seilhean, Danielle, Le Ber, Isabelle, The Brainbank Neuro-CEB Neuropathology Network, Kamermans, Alwin, Kooij, Gijs, de Vries, Helga E., Boddeke, Erik W. G. M., Seelaar, Harro, van Swieten, John C., Eggen, Bart J. L.·2022·Nature Neuroscience
DOI 10.1038/s41593-022-01124-3
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  • PlxnB1/B2 and Sema4D levels have been shown to be upregulated in aged thy-TAU22 mice by bulk RNAseq analysis and PlxnB1 in human GRN-FTD astrocytes.

    “Interestingly, PlxnB1/B2 and Sema4D levels have been shown to be upregulated in aged thy-TAU22 mice by bulk RNAseq analysis (Sierksma, Lu et al. 2020) and in PlxnB1 in human GRN-FTD astrocytes (Gerrits, Giannini et al. 2022) (Figure S8E).”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Gerrits, Giannini et al. 2022

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Metadata

Authors
Gerrits, E., Giannini, L. A. A., Brouwer, N., Melhem, S., Seilhean, D., Le Ber, I., The Brainbank Neuro-CEB Neuropathology Network, Kamermans, A., Kooij, G., de Vries, H. E., Boddeke, E. W. G. M., Seelaar, H., van Swieten, J. C., & Eggen, B. J. L.
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2022-07-25
Volume
25
Issue
8
Pages
1034-1048
ISSN
  • 1097-6256
  • 1546-1726
DOI
10.1038/s41593-022-01124-3
Cited by
88
References
18
Language
en
Licence
Funders
  • Graduate School of Medical Sciences, UMCG, RUG, The Netherlands
  • Alzheimer Nederland (WE.03.2019-09)
  • ZonMw (733050513)
  • Ministry of Economic Affairs and Climate Policy, The Netherlands

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