Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
Open accessPublished version of a preprint
Abstract
The incorporation of new information into the hippocampal network is likely to be constrained by its innate architecture and internally generated activity patterns. However, the origin, organization and consequences of such patterns remain poorly understood. In the present study we show that hippocampal network dynamics are affected by sequential neurogenesis. We birthdated CA1 pyramidal neurons with in utero electroporation over 4 embryonic days, encompassing the peak of hippocampal neurogenesis, and compared their functional features in freely moving adult mice. Neurons of the same birthdate displayed distinct connectivity, coactivity across brain states and assembly dynamics. Same-birthdate neurons exhibited overlapping spatial representations, which were maintained across different environments. Overall, the wiring and functional features of CA1 pyramidal neurons reflected a combination of birthdate and the rate of neurogenesis. These observations demonstrate that sequential neurogenesis during embryonic development shapes the preconfigured forms of adult network dynamics.
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There is evidence for a weakly preconfigured network in the telencephalon.
“Using analysis of neighbourhood distance between PCs across environments, we found evidence for a weakly preconfigured network in the telencephalon.”
From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [30]
The Discussion reports evidence for preconfigured activity patterns in hippocampal circuits, and the Results find that correlations between certain hippocampal neurons persist across changing environments. The paper's finding is specific to the hippocampus; it does not establish a preconfigured network across the telencephalon more broadly. No page numbers are available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSpatial tuning across the hippocampus is not entirely independent but may form correlated assemblies.
“This may support recent work in rodents suggesting that spatial tuning across the hippocampus is not entirely independent but may form correlated assemblies30,31,40,45.”
From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [30]
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References 103 · Cited by 104
Research works printed but not linked: 7
- [1]Amaral D, & Lavenex P in The Hippocampus Book (eds Andersen P et al.) Hippocampal Neuroanatomy (Oxford University Press, 2007).
- [2]O’keefe J & Nadel L The Hippocampus as a Cognitive Map (Oxford Univ. Press, 1978).
- [50]Rakic P in Evolutionary Developmental Biology of the Cerbral Cortex (eds Bock Gregory R. &, Cardew Gail) 30– 45 (John Wiley, 2000).
- [53]Paxinos G & Franklin KB Paxinos and Franklin’s The Mouse Brain in Stereotaxic Coordinates 5th edn (Academic Press, 2019).
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- Authors
- Huszár, R., Zhang, Y., Blockus, H., & Buzsáki, G.
- Affiliations
- New York University (US)
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- NYU Langone Health (US)
- Corresponding author
- Huszár, Roman
- Buzsáki, György
- Venue
- Nature Neuroscience
- Published
- 2022-08-22
- Volume
- 25
- Issue
- 9
- Pages
- 1201-1212
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC10807234
- OpenAlex
- W4292641205
- Cited by
- 104
- References
- 103
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 32 · 2023: 21 · 2022: 4
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (U19NS104590-01)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, CA1 pyramidal neurons, neuronal birthdate, hippocampal network dynamics, place fields, spatial representation, neuronal connectivity, in utero electroporation, embryonic development
- MeSH terms
- Animals, Hippocampus, Neurons, Pyramidal Cells, Mice, Neurogenesis
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