Effects of Dietary Methionine on Breast Muscle Growth, Myogenic Gene Expression and IGF-I Signaling in Fast- and Slow-Growing Broilers
Open accessAbstract
This study investigated the responses of fast- (FG) and slow- (SG) growing broilers to dietary methionine (Met) status. The broilers were subjected to low (LM, 0.38 and 0.28 g/100 g), adequate (AM, 0.51 and 0.42 g/100 g) and high (HM, 0.65 and 0.52 g/100 g) Met during 1-21 and 22-42 d, respectively. Compared with the LM diets, the AM and HM diets increased body weight gain only in the FG broilers. The HM diets increased breast muscle yield only in the FG broilers, although insulin-like growth factor-I (IGF-I) concentration was increased in both strains of broilers. The HM diets increased mRNA levels of myogenic regulatory factors (MRF4, Myf5) and myocyte enhancer factor 2 (MEF2A and MEF2B) in the FG broilers, and increased MEF2A and decreased myostatin mRNA level in the SG broilers. Extracellular signal-regulated kinase (ERK) phosphorylation of breast muscle was increased by the HM diets in both strains of broilers, but mechanistic target of rapamycin (mTOR) phosphorylation was increased by the AM and HM diets only in the FG broilers. These results reflect a strain difference in broiler growth and underlying mechanism in response to dietary Met.
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In broilers, high level methionine diets increase breast muscle growth by increasing mRNA levels of myogenic regulatory factors 4 and myogenic factors 5 and decreasing myostatin mRNA.
“In the broilers the high level of methionine diets increases breast muscle growth by increasing the mRNA levels of myogenic regulatory factors such as myogenic regulatory factors 4 and myogenic factors 5 and decreasing myostatin mRNA level [33].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [33]
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Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
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- Authors
- Wen, C., Jiang, X., Ding, L., Wang, T., & Zhou, Y.
- Affiliations
- Nanjing Agricultural University (CN)
- Corresponding author
- Zhou, Yanmin
- Venue
- Scientific Reports
- Published
- 2017-05-15
- Volume
- 7
- Issue
- 1
- Pages
- 1924-1924
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5432508
- OpenAlex
- W2613619256
- Cited by
- 50
- References
- 33
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 4 · 2019: 7 · 2018: 3
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK20140710)
- Fundamental Research Funds for the Central Universities (KYZ201640)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- dietary methionine, myogenic gene expression, IGF-1 signaling, fast-growing broilers, slow-growing broilers, strain differences, myostatin, MEF2A, MEF2B, Myf5, MRF4, ERK1/2 phosphorylation, mTOR phosphorylation, weight gain
- MeSH terms
- Animals, Chickens, Insulin-Like Growth Factor I, Methionine, Signal Transduction, Gene Expression, Muscle, Skeletal, Dietary Supplements
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