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Cited by 85Adipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and DiseaseGut microbiota and health

Anti-Obesity and Anti-Inflammatory Effects of Synthetic Acetic Acid Vinegar and Nipa Vinegar on High-Fat-Diet-Induced Obese Mice

Open access
Beh, Boon Kee, Mohamad, Nurul Elyani, Yeap, Swee Keong, Ky, Huynh, Boo, Sook Yee, Chua, Joelle Yi Heng, Tan, Sheau Wei, Ho, Wan Yong +3 more·2017·Scientific Reports
DOI 10.1038/s41598-017-06235-7PMC PMC5532206
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Abstract

Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice.

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  • Mice fed with a hyper-fat diet and treated with synthetic acetic acid vinegar or nipa vinegar reduced total cholesterol, triglycerides, LDL, and leptin levels.

    “Additionally, mice fed with a hyper-fat diet and treated with synthetic acetic acid vinegar or nipa vinegar reduced total cholesterol, triglycerides, LDL, and leptin levels [92].”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [92]

    The Results section, “A high dose of vinegar improved the serum lipid profiles of obese mice,” reports lower total cholesterol, triglycerides, LDL and leptin in high-dose-treated mice relative to untreated obese mice. The claim omits that dose qualification: low-dose groups showed no significant improvement in the listed lipids, and Table 1 shows no significant leptin reduction at low doses. No page number is provided in our copy. (LLM, conf=0.88)

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  • Administration of Nipa vinegar inhibited the genes expression of NF-Kb and iNOS in the liver of mice fed high-fat-diet, subsequently decreasing nitric oxide (NO) synthesis in liver.

    “Recently, Beh et al. (2017) reported that the administration of Nipa vinegar inhibited the genes expression of nuclear factor-kappa B (NF-Kb) and inducible nitric oxide synthase (iNOS) in the liver of mice fed high-fat-diet, subsequently decreasing nitric oxide (NO) synthesis in live [92].”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [92]

    The Results section ('Nipa vinegar reduced inflammation in obese mice') reports that Nipa vinegar significantly suppressed liver iNOS expression and reduced liver NO levels in high-fat-diet-induced obese mice. Although the Discussion describes suppression of both iNOS and NF-κB, the Results specify that NF-κB expression was not significantly down-regulated. The claim omits that qualification. (LLM, conf=0.87)

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Research works printed but not linked: 33

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Authors
Beh, B. K., Mohamad, N. E., Yeap, S. K., Ky, H., Boo, S. Y., Chua, J. Y. H., Tan, S. W., Ho, W. Y., Sharifuddin, S. A., Long, K., & Alitheen, N. B.
Affiliations
  • Universiti Putra Malaysia (MY)
  • University of Nottingham Malaysia Campus (MY)
  • Malaysian Agricultural Research and Development Institute (MY)
Corresponding author
Alitheen, Noorjahan Banu
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-07-27
Volume
7
Issue
1
Pages
6664-6664
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-06235-7
PMC
PMC5532206
OpenAlex
W2736833479
Cited by
85
References
37
Citations by year
2026: 1 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 16 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 7 · 2017: 2
FWCI
6.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
vinegar, acetic acid, obesity, high-fat diet, anti-obesity, anti-inflammatory activity, adipokines, lipid profile, lipid accumulation, gut microbiota, dietary intake, body weight
MeSH terms
Animals, Anti-Inflammatory Agents, Cholesterol, Gene Expression Regulation, Lipoproteins, HDL, Lipoproteins, LDL, Mice, Inbred C57BL, Mice, Obese, Obesity, Triglycerides, Acetic Acid, Anti-Obesity Agents, Lipid Metabolism, Adipokines, Diet, High-Fat

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