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Cited by 69Lymphatic System and DiseasesLymphatic Disorders and TreatmentsParasitic Diseases Research and Treatment

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Demonstration and Analysis of the Suction Effect for Pumping Lymph from Tissue Beds at Subatmospheric Pressure

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Jamalian, Samira, Jafarnejad, Mohammad, Zawieja, Scott D., Bertram, Christopher D., Gashev, Anatoliy A., Zawieja, David C., Davis, Michael J., Moore, James E.·2017·Scientific Reports
DOI 10.1038/s41598-017-11599-xPMC PMC5608746
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Abstract

Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contractile function and pressure generation with a previously validated mathematical model. We provide definitive evidence for the existence of ‘suction pressure’ in collecting lymphatic vessels, which manifests as a transient drop in pressure downstream of the inlet valve following contraction. This suction opens the inlet valve and is required for filling in the presence of low upstream pressure. Positive transmural pressure is required for this suction, providing the energy required to reopen the vessel. Alternatively, external vessel tethering can serve the same purpose when the transmural pressure is negative. Suction is transmitted upstream, allowing fluid to be drawn in through initial lymphatics. Because suction plays a major role in fluid entry to the lymphatics and is affected by interstitial pressure, our results introduce the phenomenon as another important factor to consider in the study of lymphoedema and its treatment.

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  • Expansion of the collecting LV wall during lymphatic diastole produces a transient negative pressure pulse (suction force) that is transmitted back to the lymphatic capillary network to create the hydrostatic pressure gradient that pulls interstitial fluid into the capillary lumen.

    “Expansion of the collecting LV wall during lymphatic diastole produces a transient negative pressure pulse (relative to the baseline pressure)—a suction force—that (presumably) is transmitted back to the lymphatic capillary network to create the hydrostatic pressure gradient that pulls interstitial fluid into the lumen of the capillary (51).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [51]

  • Ex vivo studies and numerical modeling show that suction is enhanced and prolonged by the addition of upstream resistance to simulate a capillary network.

    “Although transmission of suction upstream to lymphatic capillary networks has not been demonstrated in vivo, ex vivo studies and numerical modeling show that suction is enhanced and prolonged by the addition of upstream resistance to simulate a capillary network, thus providing support for this principle (51).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [51]

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Metadata

Authors
Jamalian, S., Jafarnejad, M., Zawieja, S. D., Bertram, C. D., Gashev, A. A., Zawieja, D. C., Davis, M. J., & Moore, J. E.
Affiliations
  • Imperial College London (GB)
  • University of Missouri (US)
  • The University of Sydney (AU)
  • Texas A&M University (US)
Corresponding author
  • Davis, Michael J.
  • Moore, James E.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-09-21
Volume
7
Issue
1
Pages
12080-12080
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-11599-x
PMC
PMC5608746
OpenAlex
W2755292037
Cited by
69
References
1
Citations by year
2026: 5 · 2025: 11 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 7
FWCI
2.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Royal Academy of Engineering
  • Royal Society
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL070308, R01HL120867, R01HL122578, U01HL123420, R01HL125608, R01HL096552, R01HL094269)
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
lymphatic pumping, suction pressure, sub-atmospheric pressure, lymphatic vessels, transmural pressure, interstitial fluid pressure, lymphedema
MeSH terms
Animals, Atmospheric Pressure, Lymph, Lymphatic System, Lymphedema, Male, Suction, Rats, Sprague-Dawley, Lymphatic Vessels

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