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Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
Open accessAbstract
In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (A549), which showed that the zinc alloy exhibits similar biocompatibility as compared to pure zinc. In vitro degradation evaluation was performed using weight loss and electrochemical methods in simulated body fluid (SBF) at 37 °C. Weight loss measurements revealed that the degradation of the zinc alloy was slightly lower during the initial immersion period (1-3 days), but marginally increased after 5 and 7 days immersion as compared to pure zinc. Potentiodynamic polarisation experiments showed that the zinc alloy exhibits higher degradation rate than pure zinc. However, electrochemical impedance spectroscopy analysis suggests that pure zinc is susceptible to localized degradation, whereas the zinc alloy exhibited passivation behaviour. Post-degradation analysis revealed localized degradation in both pure zinc and the zinc alloy.
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Zinc is recognised as an excellent candidate for zinc-based orthopaedic implants due to its biocompatibility and safety.
“Zinc is now recognised as an excellent candidate for zincbased orthopaedic implants, being chosen for its biocompatibility and safety (30,34).”
From Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD) (2022) · cites this paper as [30]
The Introduction describes metallic zinc as a potential biodegradable, biocompatible material for temporary orthopaedic mini-implants and discusses evidence relevant to safety. But it also says research on zinc implants is limited and notes possible cytotoxicity and localized degradation. The paper supports zinc's promise, not an unqualified claim that it is recognised as an excellent, safe implant candidate. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe present findings, with emerging use of zinc in biocompatible implants, provide a positive indication of the potential biocompatibility of a ZnIUD.
“Although there have been significantly fewer studies conducted on the interaction of zinc in the uterus compared to those of copper, the present findings, in conjunction with the emerging use of zinc in biocompatible implants provides a positive indication of the potential biocompatibility of a ZnIUD (29,30).”
From Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD) (2022) · cites this paper as [30]
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Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD)
Shankie-Williams, K., Lindsay, L., Murphy, C., & Dowland, S. (2022) · doi:10.1101/2022.03.24.485705 · Cited by 3
Metadata
- Authors
- Kannan, M. B., Moore, C., Saptarshi, S., Somasundaram, S., Rahuma, M., & Lopata, A. L.
- Affiliations
- James Cook University (AU)
- Corresponding author
- Kannan, M. Bobby
- Venue
- Scientific Reports
- Published
- 2017-11-15
- Volume
- 7
- Issue
- 1
- Pages
- 15605-15605
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5688075
- OpenAlex
- W2767250250
- Cited by
- 79
- References
- 73
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 10 · 2020: 16 · 2019: 3 · 2018: 1
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Funders
- Australian Research Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Physical Sciences › Materials Science › Metals and Alloys › Hydrogen embrittlement and corrosion behaviors in metals
- Keywords
- zinc alloys, biocompatibility, biodegradation, mini-implants, pure zinc, simulated body fluid, A549 cells, passivation, weight loss
- MeSH terms
- A549 Cells, Alloys, Biocompatible Materials, Body Fluids, Humans, Lung, Magnesium, Materials Testing, Zinc, Absorbable Implants, Electrochemical Techniques
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