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Lower levels of α-Klotho in serum are associated with decreased lung function in individuals with interstitial lung abnormalities
Open accessAbstract
Interstitial lung abnormalities (ILA) represent aging-associated bilateral interstitial abnormalities in nondependent areas of the lung. However, the aging mechanisms associated with ILA remain uncertain. α-Klotho is an anti-aging molecule that decreases progressively with age, and abnormally low circulating levels of this protein have been revealed in several chronic-degenerative diseases. In this study, we evaluated α-Klotho serum concentrations in individuals with ILA, and examined whether its levels were associated with pulmonary function decline. α-Klotho was measured by ELISA in 50 respiratory asymptomatic adults with ILA and 150 healthy individuals over 60 years. Compared with controls, ILA subjects were predominantly older males, and showed lower lung diffusing capacity (DLCO), higher desaturation after exercise, and higher concentrations of serum matrix metalloprotease-7 (6.24 ± 4.1 versus 4.3 ± 1.7 ng/ml; p = 0.002). No differences were found in serum concentrations of α-Klotho. However, lower levels of this protein in ILA significantly correlated with lower values of forced vital capacity (Rho = 0.39; p = 0.005), forced expiratory volume in one second (Rho = 0.39; p = 0.005), and DLCO (Rho = 0.29, p = 0.04). These findings suggest that decreased concentrations of α-Klotho may be a predictive biomarker of accelerated decline of lung function in individuals with ILA.
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Patients with IPF have decreased plasma α-Klotho and an increased burden of senescent cells.
“Patients with IPF have decreased plasma α-Klotho48 as well as an increased burden of senescent cells.45”
From Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans (2022) · cites this paper as [48]
The Introduction and Discussion report that circulating α-Klotho is decreased in IPF, supporting the main point attributed to this source. They do not specify plasma; this paper measured serum α-Klotho in people with interstitial lung abnormalities, not IPF. The senescent-cell claim carries a different citation and is not assessed here. (LLM, conf=0.83)
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Metadata
- Authors
- Buendia-Roldan, I., Machuca, N., Mejía, M., Maldonado, M., Pardo, A., & Selman, M.
- Affiliations
- Instituto Nacional de Enfermedades Respiratorias (MX)
- Universidad Nacional Autónoma de México (MX)
- Venue
- Scientific Reports
- Published
- 2019-07-25
- Volume
- 9
- Issue
- 1
- Pages
- 10801-10801
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6658567
- OpenAlex
- W2963394328
- Cited by
- 33
- References
- 23
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 2
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Consejo Nacional de Ciencia y Tecnología (FOSISS 290645)
- Secretaría de Ciencia, Tecnología e Innovación del Distrito Federal
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- alpha-klotho, interstitial lung abnormalities, lung function decline, aging, serum biomarkers, matrix metalloproteinase-7, forced vital capacity, diffusing capacity for carbon monoxide, anti-aging protein
- MeSH terms
- Klotho Proteins, Aged, Female, Glucuronidase, Humans, Male, Middle Aged, Biomarkers, Lung Diseases, Interstitial, Matrix Metalloproteinase 7
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