Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium
Open accessAbstract
The pathophysiology of non-pulmonary vein (PV) triggers of atrial fibrillation (AF) is unclear. We hypothesized that left atrial non-PV (LANPV) triggers are associated with atrial tissue degeneration. This study analyzed 431 patients that underwent catheter ablation (mean age 62 yrs, 303 men, 255 paroxysmal AF [pAF] patients). Clinical and electrophysiological characteristics of non-PV trigger were analyzed. Fifty non-PV triggers in 40 patients (9.3%) were documented; LANPV triggers were the most prevalent (n = 19, 38%). LANPV triggers were correlated with non-paroxysmal AF (non-pAF) (OR 3.31, p = 0.04) whereas right atrial non-PV (RANPV) triggers (n = 14) and SVC triggers (n = 17) were not. The voltage at the LANPV sites during SR was 0.3 ± 0.16 mV (p < 0.001 vs. control site). Low-voltage areas (LVAs) in the LA were significantly greater in non-pAF compared to pAF (14.2% vs. 5.8%, p < 0.01). RANPV trigger sites had preserved voltage (0.74 ± 0.48 mV). Long-term outcomes of patients with non-PV triggers treated with tailored targeting strategies were not significantly inferior to those without non-PV triggers. In conclusion, non-PV triggers arise from the LA with degeneration, which may have an important role in AF persistence. A trigger-oriented, patient-tailored ablation strategy considering LA voltage map may be feasible and effective in persistent/recurrent AF.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Atrial fibrillation can recur due to triggers outside the pulmonary veins, including ectopic activity from the posterior left atrium, superior vena cava, or coronary sinus, or from structural remodeling of the atria unrelated to the pulmonary veins, such as fibrosis, inflammation, or electrical heterogeneity.
“AF can recur due to triggers outside of these areas, including ectopic activity from the posterior left atrium, superior vena cava, or the coronary sinus, or from other mechanisms of the structural remodeling of the atria, unrelated to the pulmonary veins, such as fibrosis, inflammation, or electrical heterogeneity [91].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [91]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredPVI targets atrial fibrillation triggers originating from the pulmonary veins.
“PVI targets AF triggers originating from the pulmonary veins”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [91]
PVI ablation does not ensure the absence of non-pulmonary vein-dependent atrial fibrillation recurrences in the future.
“It is important to note that PVI ablation does not ensure the absence of non-pulmonary vein-dependent AF recurrences in the future.”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.
Haïssaguerre, M., Jaïs, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., Garrigue, S., Mouroux, A. L., Métayer, P. L., & Clémenty, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391003 · Cited by 8,040 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,119 · see citing works
Approaches to catheter ablation for persistent atrial fibrillation
Verma, A., Jiang, C.-Y., Betts, T. R., Chen, J., Deisenhofer, I., Mantovan, R., Macle, L., Morillo, C. A., Haverkamp, W., Weerasooriya, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408288 · Cited by 2,339 · see citing works
Initiation of Atrial Fibrillation by Ectopic Beats Originating From the Pulmonary Veins
Chen, S., HSIEH, M., TAI, C., Tsai, C.-F., Prakash, V. S., Yu, W., Hsu, T., Ding, Y.-A., & Chang, M.-S. (1999) · Circulation · doi:10.1161/01.cir.100.18.1879 · Cited by 1,442 · see citing works
Catheter Ablation of Paroxysmal Atrial Fibrillation Initiated by Non–Pulmonary Vein Ectopy
Lin, W., TAI, C., HSIEH, M., Tsai, C.-F., Lin, Y., Tsao, H.-M., Huang, J., Yu, W., Yang, S., Ding, Y.-A., et al. (2003) · Circulation · doi:10.1161/01.cir.0000074206.52056.2d · Cited by 751 · see citing works
Keith, A., & Flack, M. (1907) · Europe PMC (PubMed Central) · Cited by 616 · see citing works
Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation
Verma, A., Wazni, O. M., MARROUCHE, N. F., Martin, D. O., Kılıçaslan, F., Minor, S., Schweikert, R. A., Saliba, W. I., Cummings, J. E., Burkhardt, J. D., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.10.035 · Cited by 596 · see citing works
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.021 · Cited by 574 · see citing works
Rolf, S., Kircher, S., Arya, A., Eitel, C., Sommer, P., Richter, S., Gaspar, T., Bollmann, A., Altmann, D., Piedra, C., et al. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.001251 · Cited by 565 · see citing works
Electrotonic Modulation of Cardiac Impulse Conduction by Myofibroblasts
Miragoli, M., Gaudesius, G., & Rohr, S. (2006) · Circulation Research · doi:10.1161/01.res.0000214537.44195.a3 · Cited by 390 · see citing works
Yue, L., Xie, J., & Nattel, S. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq329 · Cited by 362 · see citing works
Mahnkopf, C., Badger, T. J., Burgon, N. S., Daccarett, M., Haslam, T. S., Badger, C. T., McGann, C. J., AKOUM, N. W., Kholmovski, E. G., MacLeod, R., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.06.030 · Cited by 334 · see citing works
Verma, A., Mantovan, R., Macle, L., Martino, G. D., Chen, J., Morillo, C. A., NOVAK, P. G., Calzolari, V., Guerra, P. G., Nair, G. M., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq041 · Cited by 315 · see citing works
Jadidi, A., Lehrmann, H., Keyl, C., Sorrel, J., Markstein, V., Minners, J., Park, C., Denis, A., Jaı̈s, P., Hocini, M., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.002962 · Cited by 304 · see citing works
Myofibroblasts Induce Ectopic Activity in Cardiac Tissue
Miragoli, M., Salvarani, N., & Rohr, S. (2007) · Circulation Research · doi:10.1161/circresaha.107.160549 · Cited by 303 · see citing works
Randomized Ablation Strategies for the Treatment of Persistent Atrial Fibrillation
Dixit, S., Marchlinski, F. E., Lin, D., Callans, D. J., Bala, R., Riley, M. P., Garcia, F. C., Hutchinson, M. D., Ratcliffe, S. J., Cooper, J. M., et al. (2011) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.966226 · Cited by 281 · see citing works
Predictors of Non-Pulmonary Vein Ectopic Beats Initiating Paroxysmal Atrial Fibrillation
Lee, S.-H., TAI, C., HSIEH, M., Tsao, H.-M., Lin, Y., Chang, S., Huang, J., Lee, K., Chen, Y., Cheng, J.-J., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.016 · Cited by 266 · see citing works
Santangeli, P., Zado, E. S., Hutchinson, M. D., Riley, M. P., Lin, D., Frankel, D. S., Supple, G. E., Garcia, F. C., Dixit, S., Callans, D. J., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.10.023 · Cited by 265 · see citing works
Efficacy of Left Atrial Voltage‐Based Catheter Ablation of Persistent Atrial Fibrillation
Yamaguchi, T., Tsuchiya, T., Nakahara, S., Fukui, A., Nagamoto, Y., Murotani, K., Eshima, K., & Takahashi, N. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13019 · Cited by 211 · see citing works
Bai, R., Biase, L. D., Mohanty, P. K., Trivedi, C. G., Russo, A. D., Themistoclakis, S., Casella, M., Santarelli, P., Fassini, G. M., Santangeli, P., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.08.019 · Cited by 195 · see citing works
Shah, D. C., Haı̈ssaguerre, M., Jaı̈s, P., & Hocini, M. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00243.x · Cited by 156 · see citing works
Biatrial Substrate Properties in Patients with Atrial Fibrillation
Chang, S., TAI, C., Lin, Y., Wongcharoen, W., Lo, L., Tuan, T., Udyavar, A. R., Chang, S., TSAO, H., HSIEH, M., et al. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00941.x · Cited by 140 · see citing works
Importance of nonpulmonary vein foci in catheter ablation for paroxysmal atrial fibrillation
Hayashi, K., An, Y., Nagashima, M., Hiroshima, K., Ohe, M., Makihara, Y., Yamashita, K., Yamazato, S., Fukunaga, M., Sonoda, K., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.05.003 · Cited by 134 · see citing works
Zhao, Y., Biase, L. D., Trivedi, C. G., Mohanty, S., Bai, R., Mohanty, P. K., Gianni, C., Santangeli, P., Horton, R., Sánchez, J., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.08.029 · Cited by 132 · see citing works
Blom, N. A., Groot, A. C. G., Jongeneel, T. H., DeRuiter, M. C., Poelmann, R. E., & Ottenkamp, J. J. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01363-1 · Cited by 108 · see citing works
Miyamoto, K., Tsuchiya, T., Narita, S., Yamaguchi, T., Nagamoto, Y., Ando, S., Hayashida, K., Tanioka, Y., & Takahashi, N. (2009) · EP Europace · doi:10.1093/europace/eup352 · Cited by 97 · see citing works
Inoue, K., Kurotobi, T., Kimura, R., Toyoshima, Y., Itoh, N., Masuda, M., Higuchi, Y., Date, M., Koyama, Y., Okamura, A., et al. (2011) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.964080 · Cited by 95 · see citing works
Takigawa, M., Takahashi, A., Kuwahara, T., Okubo, K., Takahashi, Y., Nakashima, E., Watari, Y., Yamao, K., Nakajima, J., Takagi, K., et al. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12681 · Cited by 95 · see citing works
Yagishita, A., Gimbel, J., Oliveira, S. D., Manyam, H., Sparano, D. M., Cakulev, I. T., Mackall, J. A., & Arruda, M. S. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13122 · Cited by 84 · see citing works
Yagishita, A., Oliveira, S. D., Cakulev, I. T., Gimbel, J., Sparano, D. M., Manyam, H., Manrique‐Garcia, A., Arredondo, M., Mackall, J. A., & Arruda, M. S. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13002 · Cited by 67 · see citing works
Multiple Arrhythmogenic Foci Associated With the Development of Perpetuation of Atrial Fibrillation
Kurotobi, T., Iwakura, K., Inoue, K., Kimura, R., Okamura, A., Koyama, Y., Tosyoshima, Y., Ito, N., & Fujii, K. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.885095 · Cited by 56 · see citing works
Hung, Y., Lo, L., Lin, Y., Chang, S., Hu, Y., Chung, F., Tuan, T., Chao, T., Liao, J., Walia, R., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.04.050 · Cited by 49 · see citing works
Recurrent atrial arrhythmias in the setting of chronic pulmonary vein isolation
Sadek, M. M., Maeda, S., CHIK, W. W. B., Santangeli, P., Zado, E. S., Schaller, R. D., Supple, G. E., Frankel, D. S., Hutchinson, M. D., Garcia, F. C., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.08.026 · Cited by 36 · see citing works
Jadidi, A., Lehrmann, H., Keyl, C., Sorrel, J., Markstein, V., Minners, J., Park, C., Denis, A., Jaı̈s, P., Hocini, M., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004312 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rocca, D. G. D., Biase, L. D., Mohanty, S., Trivedi, C. G., Gianni, C., Romero, J. E., Tarantino, N. M., Magnocavallo, M., Bassiouny, M., Natale, V. N., et al. (2021) · EP Europace · doi:10.1093/europace/euab161 · Cited by 88 · see citing works
Rocca, D. G. D., Tarantino, N. M., Trivedi, C. G., Mohanty, S., Anannab, A., Salwan, A. S., Gianni, C., Bassiouny, M., Al‐Ahmad, A., Romero, J. E., et al. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14638 · Cited by 79 · see citing works
Jadidi, A., Nothstein, M., Chen, J., Lehrmann, H., Dössel, O., Allgeier, J., Trenk, D., Neumann, F., Loewe, A., Müller‐Edenborn, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65564-2 · Cited by 47 · see citing works
Tohoku, S., Fukunaga, M., Nagashima, M., Korai, K., Hirokami, J., Yamamoto, K., Takeo, A., Niu, H., Andò, K., & Hiroshima, K. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14830 · Cited by 38 · see citing works
Overeinder, I., Osório, T. G., Călburean, P., Bisignani, A., Bala, G., Sieira, J. A., Ströker, E., Housari, M. A., Mojica, J. V., Bovéda, S., et al. (2021) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00932-6 · Cited by 25 · see citing works
Takamiya, T., Nitta, J., Inaba, O., Sato, A., Inamura, Y., Murata, K., Ikenouchi, T., Kono, T., Takahashi, Y., Goya, M., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15002 · Cited by 23 · see citing works
Knecht, S., Zeljković, I., Badertscher, P., Krisai, P., Spies, F., Vognstrup, J., Pavlović, N., Manola, Š., Osswald, S., Kühne, M., et al. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01314-w · Cited by 21 · see citing works
Bisignani, A., Overeinder, I., Kazawa, S., Iacopino, S., Cecchini, F., Miraglia, V., Osório, T. G., Bovéda, S., Bala, G., Mugnai, G., et al. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00812-z · Cited by 20 · see citing works
Predictors of recurrent atrial fibrillation following catheter ablation
Mohanty, S., Rocca, D. G. D., Gianni, C., Trivedi, C. G., Mayedo, A., MacDonald, B. C., & Natale, A. (2021) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2021.1892490 · Cited by 18 · see citing works
Ikenouchi, T., Nitta, J., Inaba, O., Kono, T., Murata, K., Takamiya, T., Inamura, Y., Sato, A., Matsumura, Y., Takahashi, Y., et al. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01217-w · Cited by 16 · see citing works
Predictors of nonpulmonary vein triggers for atrial fibrillation: A clinical risk score
Thind, M., Oraii, A., Chaumont, C., Arceluz, M. R., Sekigawa, M., Yogasundaram, H., Sugrue, A. M., Mirwais, M., Alsalem, A. B., Zado, E. S., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.01.048 · Cited by 15 · see citing works
Nair, G. M., Birnie, D. H., Nery, P. B., Redpath, C. J., SARRAZIN, J., Roux, J.-F., Parkash, R., Bernier, M., Sterns, L. D., Sapp, J. L., et al. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.0212 · Cited by 14 · see citing works
Gander, L., Pezzuto, S., Gharaviri, A., Krause, R., Perdikaris, P. G., & Costabal, F. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.757159 · Cited by 14 · see citing works
Embryological Classification of Arrhythmogenic Triggers Initiating Atrial Fibrillation
Ikenouchi, T., Nitta, J., Inaba, O., Negishi, M., Amemiya, M., Kono, T., Yamamoto, T., Murata, K., Kawamura, I., Goto, K., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.08.060 · Cited by 13 · see citing works
Cutler, M. J., Sattayaprasert, P., Pivato, E., Jabri, A., Almahameed, S., & Ziv, O. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15464 · Cited by 12 · see citing works
Saito, J., Yamashita, K., Numajiri, T., Gibo, Y., Usumoto, S., Narui, S., Fujioka, T., Asukai, Y., Igawa, W., Ono, M., et al. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15498 · Cited by 11 · see citing works
Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. S., & Tsutsui, H. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15371 · Cited by 9 · see citing works
Self-citationSex Differences in Atrial Fibrillation
Mukai, Y. (2022) · Circulation Journal · doi:10.1253/circj.cj-21-1072 · Cited by 8 · see citing works
Self-citationAtrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature
Kourek, C., Briasoulis, A., Tsougos, E., & Paraskevaidis, I. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11100315 · Cited by 7 · see citing works
Oliva, C.-A., Morello, M., Kron, J., Ellenbogen, K. A., Golino, M., & Ponti, R. D. (2025) · EP Europace · doi:10.1093/europace/euaf206 · Cited by 9 · see citing works
Salih, A. A., Sutaria, A., Montaser, Z., Magar, T. P., Ashal, G. E., Zaghloul, S., Tom, A. J., Ahmad, M., Creta, A., Ali, H., et al. (2025) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16723 · Cited by 7 · see citing works
A case report of paroxysmal atrial fibrillation in three pulmonary veins presenting a common trunk
Kujiraoka, H., Hojo, R., Takahashi, M., & Fukamizu, S. (2022) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytac481 · Cited by 7 · see citing works
Yamada, S., Kaneshiro, T., Nodera, M., Amami, K., Nehashi, T., Oikawa, M., Yamaki, T., Nakazato, K., Ishida, T., & Takeishi, Y. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13045 · Cited by 7 · see citing works
Sex-Related Differences in Non–Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation
Chaumont, C., Oraii, A., Rodríguez-Queraltó, O., Petzl, A. M., Zado, E. S., Hanumanthu, B. K. J., Markman, T. M., Hyman, M. C., Tschabrunn, C. M., Enriquez, A. A., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.29527 · Cited by 6 · see citing works
Atrial fibrillation: from pathogenesis to novel treatment options
Liu, Y., Chen, Y., Ren, Q., Zhang, H., Huang, H., Luo, Z. W., Xiao, X., Chen, X., Li, J., Zhang, Q., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00393-1 · Cited by 6 · see citing works
van Schie, M. S., Liao, R., Misier, N. L. R., Knops, P., Heida, A., Taverne, Y. J. H. J., & de Groot, N. M. S. (2023) · EP Europace · doi:10.1093/europace/euad223 · Cited by 6 · see citing works
Veen, D., Verbeek, E. C., Kavousi, M., Huigen, J., Mijnen-Schra, A., Cocchieri, R., Khan, M., & de Groot, N. M. S. (2023) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2023.101262 · Cited by 6 · see citing works
Park, I. J., Kim, D., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., Hwang, C., & Pak, H. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13003 · Cited by 5 · see citing works
Bigeminal potentials in the pulmonary vein indicate arrhythmogenic trigger of atrial fibrillation
Mukai, Y., Kawai, S., Inoue, S., Takase, S., Sakamoto, K., Nagaoka, K., Chishaki, A. S., & Tsutsui, H. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12462 · Cited by 5 · see citing works
Self-citationSolimene, F., Stabile, G., Segreti, L., Malacrida, M., Schillaci, V., Rossi, P., Bongiorni, M. G., Shopova, G., Cauti, F. M., Zucchelli, G., et al. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15527 · Cited by 5 · see citing works
Pannone, L., Bisignani, A., Sorgente, A., Gauthey, A., Rocca, D. G. D., Monaco, C., Bories, W., Ramak, R., Overeinder, I., Bala, G., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102948 · Cited by 5 · see citing works
Atrial fibrillation substrate mapping with emphasis on voltage-based guidance
Ciaccio, E. J., Hsia, H. H., Yarmohammadi, H., Wan, E. Y., Peters, N. S., Saluja, D. S., & BIVIANO, A. B. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i11.109739 · Cited by 4 · see citing works
Comparison of voltages between atria: differences in sinus rhythm and atrial fibrillation
Bates, A. P., Paisey, J., YUE, A. M., Banks, P., Roberts, P. R., & Ullah, W. (2023) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-023-01671-0 · Cited by 4 · see citing works
Pašara, V., Ban, B., Prepolec, I., Nekić, A., Katić, Z., Kardum, D., Miličić, D., & Velagić, V. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134422 · Cited by 4 · see citing works
Kokubu, Y., Watanabe, T., Yamada, T., Morita, T., Kawasaki, M., Kikuchi, A., Kondo, T., Kawai, T., Nishimoto, Y., Seo, M., et al. (2023) · Internal Medicine · doi:10.2169/internalmedicine.2005-23 · Cited by 4 · see citing works
Simulation-free prediction of atrial fibrillation inducibility with the fibrotic kernel signature
Banduc, T., Azzolin, L., Manninger, M., Scherr, D., Plank, G., Pezzuto, S., & Costabal, F. S. (2024) · Medical Image Analysis · doi:10.1016/j.media.2024.103375 · Cited by 4 · see citing works
Hwang, I., Kwon, O., Hong, M., Yang, S.-Y., Park, J., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.807545 · Cited by 4 · see citing works
Huang, Y., Pak, H., Hiroshima, K., Yamaguchi, T., Chen, Y., Fukaya, H., Soejima, K., Yan, B. P., Morishima, I., Shizuta, S., et al. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13168 · Cited by 3 · see citing works
Miraglia, V., Bisignani, A., Pannone, L., Iacopino, S., Chierchia, G., & de Asmundis, C. (2022) · Expert Review of Medical Devices · doi:10.1080/17434440.2022.2096437 · Cited by 3 · see citing works
Tsuruta, Y., Kanazawa, H., Tsurusaki, Y., Matsunaga, K., Sumi, H., Kaneko, S., Hoshiyama, T., Shirahama, Y., Kuyama, N., Yamamoto, M., et al. (2025) · Heart Rhythm O2 · doi:10.1016/j.hroo.2025.09.025 · Cited by 2 · see citing works
Sakamoto, K., Mukai, Y., Kawai, S., Nagaoka, K., Inoue, S., Takase, S., Yakabe, D., Ikeda, S., Mannoji, H., Nagayama, T., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264894 · Cited by 2 · see citing works
Self-citationCryoballoon ablation of non‐PV triggers in persistent atrial fibrillation
Çöteli, C., Dural, M., Yorgun, H., & Aytemir, K. (2023) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14878 · Cited by 2 · see citing works
Extrasystolic arrhythmia as an atrial fibrillation predictor
Kunts, L. D., Андреевна, Г. О., Reshetnikova, Y. B., Galati, G., Milevskaya, I. A., & Biondi‐Zoccai, G. (2024) · Science and Innovations in Medicine · doi:10.35693/sim624503 · Cited by 2 · see citing works
Hoshiyama, T., Ashikaga, K., Morihisa, K., Ito, M., Oniki, K., Saruwatari, J., Ishii, M., Kanazawa, H., Sumi, H., Kaneko, S., et al. (2024) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.124.013433 · Cited by 2 · see citing works
Pandey, N., Murray, B., Golian, M., Klein, A., Hansom, S. P., Sadek, M. M., Weng, W., Redpath, C. J., Nery, P. B., Nair, G. M., et al. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.02.033 · Cited by 2 · see citing works
Chen, Y., Zhou, H., Wu, L., Lu, Y., He, L., Bu, M., Xu, D., & Xingfu, H. (2025) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2025.2516945 · Cited by 2 · see citing works
Kumagai, K. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15376 · Cited by 2 · see citing works
Yamada, S., Kaneshiro, T., Nodera, M., Amami, K., Nehashi, T., Horikoshi, Y., Yamadera, Y., & Takeishi, Y. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16009 · Cited by 2 · see citing works
Left Atrial Electroanatomical Voltage Mapping to Characterize Substrate and Guide Ablation
Dhakal, B. P., & Hutchinson, M. D. (2020) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-020-00833-x · Cited by 2 · see citing works
Focal activity in atrial fibrillation: state of the art
Aleksandrova, I. S., & Chapurnykh, A. V. (2023) · Journal of Arrhythmology · doi:10.35336/va-2023-2-12 · Cited by 1 · see citing works
Kawai, S., Sakamoto, K., Tanaka, A., Inoue, S., Nagaoka, K., Matsuura, H., Takase, S., Nozoe, M., Abe, K., Mukai, Y., et al. (2025) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16752 · Cited by 1 · see citing works
Self-citationTohyama, T., Sakamoto, K., Nagayama, T., Yokoyama, H., Watanabe, T., Mukai, Y., Kawai, S., Yakabe, D., Mannoji, H., Nagaoka, K., et al. (2026) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztag054 · Cited by 1 · see citing works
Self-citationGenetic Variants Associated With Nonpulmonary Vein Triggers of Atrial Fibrillation
Okamura, S., Furutani, M., Nakashima, M., Oda, N., Tokuyama, T., Okubo, Y., Miyauchi, S., Miyamoto, S., Oguri, N., Sakai, T., et al. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102839 · Cited by 2 · see citing works
Nonpharmacological Approach to Managing Atrial Fibrillation: A Review
Ifiora, F. C., Agudosi, G. M., Ekpemiro, C. U., Keke, V., Okoh, P., Oyesile, A. Y., Mbah, L. A., Akueme, N. T., Akanle, O. E., Anebere, R., et al. (2023) · Cardiology and Angiology An International Journal · doi:10.9734/ca/2023/v12i4364 · Cited by 1 · see citing works
Voltage-Guided Ablation for Atrial Fibrillation -- Current Insights and Future DirectionsPreprint
Valli, H., Deshmukh, A. J., Nanthakumar, K., Wong, T., & Haldar, S. (2023) · doi:10.22541/au.168483251.13504722/v1 · Cited by 1 · see citing works
Canpolat, U. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15608
Case report of persistent atrial fibrillation with durably isolated pulmonary veins: what’s next?
Bengel, P., Sossalla, S. T., & Dinov, B. (2024) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytae358
Wei, Z., Gong, L., Wang, Z., Zuo, Z., & Zhang, Z. (2024) · Clinical Case Reports · doi:10.1002/ccr3.70042
Distribution Patterns of Paroxysmal Atrial Fibrillation Triggers and Catheter Ablation Success Rates
Zhao, D., Dong, Y., Chen, Q., Zhang, F., & Zheng, K. (2025) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.70065
AI-Driven Evaluation of Voltage Maps in Patients with Atrial Fibrillation: Proof-of-Concept StudyPreprint
Tohyama, T., Sakamoto, K., Nagayama, T., Yokoyama, H., Watanabe, T., Mukai, Y., Kawai, S., Yakabe, D., Mannouji, H., Nagaoka, K., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5368725
Self-citationSex Differences in Patients with Atrial Fibrillation Undergoing Catheter Ablation
Fujimura, T., Kishi, T., Takamori, A., Yamamoto, T., Katagiri, T., Kajiwara, M., Tomita, S., Nishinosono, S., Hirai, Y., Inage, T., et al. (2025) · International Heart Journal · doi:10.1536/ihj.25-172
Non–Pulmonary Vein Triggers—Does Sex Matter?
Jebbawi, L. A., & Khan, A. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.29535
Matsuda, Y., Masuda, M., Mano, T., Tsujimura, T., Uematsu, H., Ooka, H., Kudo, S., Ochi, M., Okamoto, S., Ishihara, T., et al. (2025) · EP Europace · doi:10.1093/europace/euaf205
Wu, S., Chen, Z., Li, Z., Sun, X., Tao, Z., Li, X., Chen, H., & Chen, M. (2025) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-025-02181-x
Tcivkovskii, V., Чапурных, А. В., Nizhnichenko, V. A., & Mitin, A. S. (2026) · Journal of Arrhythmology · doi:10.35336/va-1555
Sehrawat, O., Garg, V., Foo, C. Y., Xue, C., Khandekar, N., Matai, P., Asirvatham, S. J., Siontis, K. C., & Noseworthy, P. A. (2026) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.70296
Abe, K., Nagaoka, K., Mukai, Y., Kojima, H., Hayashidani, S., & Tashiro, H. (2026) · Journal of Cardiology Cases · doi:10.1016/j.jccase.2026.06.008
Self-citationIshikura, M., Shinoda, A., Takase, T., & Furukawa, Y. (2026) · HeartRhythm Case Reports · doi:10.1016/j.hrcr.2026.08.020
Kawai, S., Okahara, A., Tokutome, M., Matsuura, H., Yakabe, D., Masunaga, T., Yamamoto, T., Sakamoto, K., Oga, Y., & Mukai, Y. (2026) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.70502
Self-citationKim, D., Lee, K., Park, H., Yu, H. T., Kim, T., Roh, S., Uhm, J., Joung, B., Lee, D.-I., Kim, Y.-H., et al. (2026) · American Heart Journal · doi:10.1016/j.ahj.2026.107624
- Authors
- Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A., & Tsutsui, H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Mukai, Yasushi
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-08-22
- Volume
- 9
- Issue
- 1
- Pages
- 12271-12271
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6706423
- OpenAlex
- W2969790472
- Cited by
- 70
- References
- 34
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 5 · 2020: 5
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Bristol-Myers Squibb (#GAKF850098)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, non-pulmonary vein triggers, left atrium, low-voltage areas, catheter ablation, paroxysmal atrial fibrillation, non-paroxysmal atrial fibrillation, persistent atrial fibrillation
- MeSH terms
- Aged, Atrial Fibrillation, Female, Follow-Up Studies, Heart Atria, Humans, Male, Middle Aged, Pulmonary Veins, Catheter Ablation, Electrophysiologic Techniques, Cardiac
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
