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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population

Open access
Evans, Benjamin R., Kotsakiozi, Panayiota, Costa-da-Silva, Andre Luis, Ioshino, Rafaella Sayuri, Garziera, Luiza, Pedrosa, Michele C., Malavasi, Aldo, Virginio, Jair F., Capurro, Margareth L., Powell, Jeffrey R.·2019·Scientific Reports
DOI 10.1038/s41598-019-49660-6
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Abstract

In an attempt to control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed by a commercial company, Oxitec Ltd. If lethality is complete, releasing this strain should only reduce population size and not affect the genetics of the target populations. Approximately 450 thousand males of this strain were released each week for 27 months in Jacobina, Bahia, Brazil. We genotyped the release strain and the target Jacobina population before releases began for >21,000 single nucleotide polymorphisms (SNPs). Genetic sampling from the target population six, 12, and 27–30 months after releases commenced provides clear evidence that portions of the transgenic strain genome have been incorporated into the target population. Evidently, rare viable hybrid offspring between the release strain and the Jacobina population are sufficiently robust to be able to reproduce in nature. The release strain was developed using a strain originally from Cuba, then outcrossed to a Mexican population. Thus, Jacobina Ae. aegypti are now a mix of three populations. It is unclear how this may affect disease transmission or affect other efforts to control these dangerous vectors. These results highlight the importance of having in place a genetic monitoring program during such releases to detect un-anticipated outcomes.

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Metadata

Authors
Evans, B. R., Kotsakiozi, P., Costa-da-Silva, A. L., Ioshino, R. S., Garziera, L., Pedrosa, M. C., Malavasi, A., Virginio, J. F., Capurro, M. L., & Powell, J. R.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2019-09-10
Volume
9
Issue
1
Pages
13047-13047
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-019-49660-6
OpenAlex
W2972679514
Cited by
732
References
15
FWCI
145.39
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population. https://app.cochat.ai/papers/10.1038/s41598-019-49660-6
The paper
Evans, B. R., Kotsakiozi, P., Costa-da-Silva, A. L., Ioshino, R. S., Garziera, L., Pedrosa, M. C., Malavasi, A., Virginio, J. F., Capurro, M. L., & Powell, J. R. (2019). Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population. Scientific Reports. https://doi.org/10.1038/s41598-019-49660-6

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.