The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Insect Population Control Using a Dominant, Repressible, Lethal Genetic System
Abstract
A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non–sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently in Drosophila melanogaster , and we expect these principles to be widely applicable to more economically important organisms .
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943
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Sterile-Insect Methods for Control of Mosquito-Borne Diseases: An Analysis
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Self-citationBiological Control of Mosquito Vectors: Past, Present, and Future
Benelli, G., Jeffries, C., & Walker, T. (2016) · Insects · doi:10.3390/insects7040052 · Cited by 445
Harris, A. F., McKemey, A. R., Nimmo, D., Curtis, Z., Black, I., Morgan, S. A., Oviedo, M. N., Lacroix, R., Naish, N., Morrison, N. I., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2350 · Cited by 397
Self-citationMosquito behavior and vector control
Pates, H., & Curtis, C. (2005) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130439 · Cited by 403
Metadata
- Authors
- Thomas, D. D., Donnelly, C. A., Wood, R. J., & Alphey, L. S.
- Venue
- Science
- Published
- 2000-03-31
- Volume
- 287
- Issue
- 5462
- Pages
- 2474-2476
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081185991
- Cited by
- 619
- References
- 1
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thomas, D. D., Donnelly, C. A., Wood, R. J., & Alphey, L. S. (2000). Insect Population Control Using a Dominant, Repressible, Lethal Genetic System. Science. https://doi.org/10.1126/science.287.5462.2474
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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