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Cited by 23Dementia and Cognitive Impairment ResearchEpigenetics and DNA MethylationAlzheimer's disease research and treatments

Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

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Kobayashi, Nobuyuki, Shinagawa, Shunichiro, Niimura, Hidehito, Kida, Hisashi, Nagata, Tomoyuki, Tagai, Kenji, Shimada, Kazuya, Oka, Naomi +6 more·2020·Scientific Reports
DOI 10.1038/s41598-020-69248-9PMC PMC7376092
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Abstract

Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is associated with neurodegeneration through a comparison of AD, AD with cardiovascular disease (CVD), and vascular dementia (VaD). We measured blood COASY methylation levels in normal controls (NCs) (n = 200), and individuals with aMCI (n = 22), AD (n = 151), and VaD (n = 21). Compared with NCs, they were significantly higher in individuals with aMCI and AD. Further, they were significantly higher in AD patients without cardiovascular diseases compared to AD patients with them. These findings suggest that COASY methylation levels may be related to neurodegeneration in AD.

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Cited by

Sorted by citations

Authors
Kobayashi, N., Shinagawa, S., Niimura, H., Kida, H., Nagata, T., Tagai, K., Shimada, K., Oka, N., Shikimoto, R., Noda, Y., Nakajima, S., Mimura, M., Shigeta, M., & Kondo, K.
Affiliations
  • Jikei University School of Medicine (JP)
  • Keio University (JP)
Corresponding author
Kobayashi, Nobuyuki
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2020-07-22
Volume
10
Issue
1
Pages
12217-12217
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-020-69248-9
PMC
PMC7376092
OpenAlex
W3044091925
Cited by
23
References
0
Citations by year
2025: 4 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 1
FWCI
2.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science (17K10318, 17K10317)
  • Mitsui Life Social Welfare Foundation
  • Japan Agency for Medical Research and Development (18dk0207025h0003)
  • Private University Research Branding Project from the Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, DNA methylation, blood biomarkers, amnestic mild cognitive impairment, vascular dementia, cardiovascular disease, neurodegeneration, early diagnosis of dementia, epigenetics
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Base Sequence, Cardiovascular Diseases, Female, Genotype, Humans, Male, Promoter Regions, Genetic, ROC Curve, Severity of Illness Index, Transferases, Dementia, Vascular, Biomarkers, Case-Control Studies, DNA Methylation, Area Under Curve, Cognitive Dysfunction

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