Current concepts in mild cognitive impairment
Abstract
The field of aging and dementia is focusing on the characterization of the earliest stages of cognitive impairment. Recent research has identified a transitional state between the cognitive changes of normal aging and Alzheimer's disease (AD), known as mild cognitive impairment (MCI). Mild cognitive impairment refers to the clinical condition between normal aging and AD in which persons experience memory loss to a greater extent than one would expect for age, yet they do not meet currently accepted criteria for clinically probable AD. When these persons are observed longitudinally, they progress to clinically probable AD at a considerably accelerated rate compared with healthy age-matched individuals. Consequently, this condition has been recognized as suitable for possible therapeutic intervention, and several multicenter international treatment trials are under way. Because this is a topic of intense interest, a group of experts on aging and MCI from around the world in the fields of neurology, psychiatry, geriatrics, neuropsychology, neuroimaging, neuropathology, clinical trials, and ethics was convened to summarize the current state of the field of MCI. Participants reviewed the world scientific literature on aging and MCI and summarized the various topics with respect to available evidence on MCI. Diagnostic criteria and clinical outcomes of these subjects are available in the literature. Mild cognitive impairment is believed to be a high-risk condition for the developme…
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Diagnoses of MCI were made according to the Petersen criteria for MCI.
“Diagnoses of MCI was made according to the Petersen criteria for MCI (Petersen et al., 2001)”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Petersen et al., 2001
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- Authors
- Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B.
- Affiliations
- Mayo Clinic (US)
- Baylor College of Medicine (US)
- Technical University of Munich (DE)
- Icahn School of Medicine at Mount Sinai (US)
- Washington University in St. Louis (US)
- Johns Hopkins University (US)
- Inserm (FR)
- University College London (GB)
- University of California San Diego (US)
- Karolinska Institutet (SE)
- ORCID
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2001-12-01
- Volume
- 58
- Issue
- 12
- Pages
- 1985
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2113708991
- Cited by
- 4,781
- References
- 7
- Citations by year
- 2026: 72 · 2025: 154 · 2024: 149 · 2023: 137 · 2022: 158 · 2021: 240 · 2020: 222 · 2019: 216 · 2018: 154 · 2017: 183 · 2016: 231 · 2015: 239 · 2014: 249 · 2013: 250 · 2012: 270
- FWCI
- 53.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- mild cognitive impairment, Alzheimer's disease, normal aging, memory loss, conversion to dementia, diagnostic criteria, therapeutic interventions, clinical trials, aging
- MeSH terms
- Aged, Aging, Cognition Disorders, Female, Humans
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