Detection of synovitis in early knee osteoarthritis by MRI and serum biomarkers in Japanese general population

Knee Injury and Osteoarthritis Outcome Score (KOOS)—Development of a Self-Administered Outcome Measure

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Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis

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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

Sellam, J., & Berenbaum, F. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.159 · Cited by 1,500 · see citing works

Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study

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Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state

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Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients

Ayral, X., Pickering, E., WOODWORTH, T. G., Mackillop, N., & Dougados, M. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.01.005 · Cited by 577 · see citing works

Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)

Guermazi, A., Niu, J., Hayashi, D., Roemer, F. W., Englund, M., Neogi, T., Aliabadi, P., McLennan, C. E., & Felson, D. T. (2012) · BMJ · doi:10.1136/bmj.e5339 · Cited by 514 · see citing works

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

Roemer, F. W., Guermazi, A., Felson, D. T., Niu, J., Nevitt, M. C., Crema, M. D., Lynch, J. A., Lewis, C. E., Torner, J. C., & Zhang, Y. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.150243 · Cited by 367 · see citing works

Relation of synovitis to knee pain using contrast-enhanced MRIs

Baker, K., Grainger, A. J., Niu, J., Clancy, M. M., Guermazi, A., Crema, M. D., Hughes, L., Buckwalter, J. A., Wooley, A., Nevitt, M. C., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.121426 · Cited by 339 · see citing works

IL-6 and its circadian secretion in humans

Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338 · see citing works

Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

Hiligsmann, M., Cooper, C. C., Arden, N., Boers, M., Branco, J., Brandi, M. L., Bruyère, O., Guillemin, F., Hochberg, M. C., Hunter, D. J., et al. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.07.003 · Cited by 328 · see citing works

The evolving role of obesity in knee osteoarthritis

Sowers, M. R., & Karvonen-Gutierrez, C. A. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32833b4682 · Cited by 305 · see citing works

Synovitis and the risk of knee osteoarthritis: the MOST Study

Felson, D. T., Niu, J., Neogi, T., Goggins, J., Nevitt, M. C., Roemer, F. W., Torner, J. C., Lewis, C. E., & Guermazi, A. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.09.013 · Cited by 266 · see citing works

Mechanical Compression of Cartilage Explants Induces Multiple Time-dependent Gene Expression Patterns and Involves Intracellular Calcium and Cyclic AMP

Fitzgerald, J. B., Jin, M. M., Dean, D. M. D., Wood, D., Zheng, M., & Grodzinsky, A. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400437200 · Cited by 252 · see citing works

Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions

Bekkers, J. E. J., de Windt, T. S., Raijmakers, N. J. H., Dhert, W. J. A., & Saris, D. B. F. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.04.019 · Cited by 239 · see citing works

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease

Scanzello, C. R., Umoh, E. M., Peßler, F., Díaz‐Torné, C., Miles, T., DiCarlo, E. F., Potter, H. G., Mandl, L. A., Marx, R. G., Rodeo, S. A., et al. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.02.011 · Cited by 233 · see citing works

Toward classification criteria for early osteoarthritis of the knee

Luyten, F. P., Bierma‐Zeinstra, S., Dell’Accio, F., Kraus, V. B., Nakata, K., Sekiya, I., Arden, N., & Lohmander, S. L. (2017) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2017.08.006 · Cited by 209 · see citing works

Cross-cultural adaptation and validation of the Japanese Knee Injury and Osteoarthritis Outcome Score (KOOS)

Nakamura, N., Takeuchi, R., Ishikawa, H. T., Saito, T., Sawaguchi, T., & Goldhahn, S. (2011) · Journal of Orthopaedic Science · doi:10.1007/s00776-011-0112-9 · Cited by 183 · see citing works

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

Yusuf, E., Ioan‐Facsinay, A., Bijsterbosch, J., Klein‐Wieringa, I. R., Kwekkeboom, J. C., Slagboom, P. E., Huizinga, T. W. J., & Kloppenburg, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.146282 · Cited by 154 · see citing works

Imaging of Synovitis in Osteoarthritis: Current Status and Outlook

Hayashi, D., Roemer, F. W., Katur, A. M., Felson, D. T., Yang, S.-O., Alomran, F., & Guermazi, A. (2011) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2010.12.003 · Cited by 133 · see citing works

Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis

Ishijima, M., Watari, T., Naito, K., Kaneko, H., Futami, I., YOSHIMURA, K., Tomonaga, A., Yamaguchi, H., Yamamoto, T., Nagaoka, I., et al. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3246 · Cited by 132 · see citing works

Epidemic Inflammation: Pondering Obesity

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Correlation of Plasma and Synovial Fluid Adiponectin with Knee Osteoarthritis Severity

Honsawek, S., & Chayanupatkul, M. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.11.007 · Cited by 110 · see citing works

Osteoarthritis and obesity: Experimental models

Gabay, O., Hall, D. J., Berenbaum, F., Henrotin, Y. E., & Sanchez, C. (2008) · Joint Bone Spine · doi:10.1016/j.jbspin.2008.07.011 · Cited by 102 · see citing works

The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study

Shimura, Y., Kurosawa, H., Sugawara, Y., Tsuchiya, M., Sawa, M., Kaneko, H., Futami, I., Liu, L., SADATSUKI, R., HADA, S., et al. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.05.014 · Cited by 91 · see citing works

Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

Ma, J., Zhou, J., Zheng, D.-H., Chen, L., Mo, Y., Wei, X., Yang, L., & Dai, L. (2014) · Mediators of Inflammation · doi:10.1155/2014/179284 · Cited by 73 · see citing works

Biomarkers of incident radiographic knee osteoarthritis: Do they vary by chronic knee symptoms?

Golightly, Y. M., Marshall, S. W., Kraus, V. B., Renner, J. B., Villaveces, A., Casteel, C. H., & Jordan, J. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30412 · Cited by 69 · see citing works

High Adiponectin and Adiponectin Receptor 1 Expression in Synovial Fluids and Synovial Tissues of Patients with Rheumatoid Arthritis

Tan, W., Wang, F., Zhang, M., Guo, D., Zhang, Q., & He, S. (2008) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.01.017 · Cited by 68 · see citing works

Early knee osteoarthritis prevalence is highest among middle-aged adult females with obesity based on new set of diagnostic criteria from a large sample cohort study in the Japanese general population

Sasaki, E., Ota, S., Chiba, D., Kimura, Y., Sasaki, S., Yamamoto, Y., Tsuda, E., Nakaji, S., & Ishibashi, Y. (2019) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-019-05614-z · Cited by 68 · see citing works

Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population

Inoüe, R., Ishibashi, Y., Tsuda, E., Yamamoto, Y., Matsuzaka, M., Takahashi, I., Danjo, K., Umeda, T., Nakaji, S., & Toh, S. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.10.021 · Cited by 62 · see citing works

Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis – a five-year prospective cohort study

Sasaki, E., Tsuda, E., Yamamoto, Y., Maeda, S., Inoüe, R., Chiba, D., Fujita, H., Takahashi, I., Umeda, T., Nakaji, S., et al. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0793-0 · Cited by 53 · see citing works

MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy

Pengas, I. P., Eldridge, S. E., Assiotis, A., McNicholas, M. J., Espregueira‐Mendes, J., & Laver, L. (2018) · Journal of Experimental Orthopaedics · doi:10.1186/s40634-018-0132-x · Cited by 51 · see citing works

Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis—the CHECK study

van Oudenaarde, K., Jobke, B., Oostveen, A. C. M., Marijnissen, A. C., Wolterbeek, R., Wesseling, J., Bierma‐Zeinstra, S., Bloem, H. L., Reijnierse, M., & Kloppenburg, M. (2016) · Lara D. Veeken · doi:10.1093/rheumatology/kew368 · Cited by 45 · see citing works

Adiponectin: is it a biomarker for assessing the disease severity in knee osteoarthritis patients?

COŞKUN, N. C., Ay, S., Evcik, F. D., & Öztuna, D. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12790 · Cited by 44 · see citing works

Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Harkey, M. S., Davis, J. E., Lü, B., Price, L. L., Ward, R. J., Mackay, J., Eaton, C. B., Lo, G. H., Barbe, M. F., Zhang, M., et al. (2019) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-019-2624-y · Cited by 43 · see citing works

Meniscal extrusion seen on ultrasonography affects the development of radiographic knee osteoarthritis: a 3-year prospective cohort study

Chiba, D., Maeda, S., Sasaki, E., Ota, S., Nakaji, S., Tsuda, E., & Ishibashi, Y. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3803-6 · Cited by 43 · see citing works

A naturally aging knee, or development of early knee osteoarthritis?

Magnusson, K., Kumm, J., Turkiewicz, A., & Englund, M. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.04.020 · Cited by 38 · see citing works

Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study

Ota, S., Chiba, D., Sasaki, E., Kumagai, G., Yamamoto, Y., Nakaji, S., Tsuda, E., & Ishibashi, Y. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1900-4 · Cited by 35 · see citing works

Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative

Deveza, L. A., Kraus, V. B., Collins, J., Guermazi, A., Roemer, F. W., Nevitt, M. C., & Hunter, D. J. (2017) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2017.1340511 · Cited by 32 · see citing works

Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease

Kumar, R., Sporn, K., Borole, A., Khanna, A., Gowda, C., Paladugu, P., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111418 · Cited by 10 · see citing works