IL-6 and its circadian secretion in humans
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by numerous types of immune and nonimmune cells and is involved in many pathophysiologic mechanisms in humans. Many studies suggest that IL-6 is a putative ‘sleep factor’ and its circadian secretion correlates with sleep/sleepiness. IL-6 is elevated in disorders of excessive daytime sleepiness such as narcolepsy and obstructive sleep apnea. It correlates positively with body mass index and may be a mediator of sleepiness in obesity. Also the secretion of this cytokine is stimulated by total acute or partial short-term sleep loss reflecting the increased sleepiness experienced by sleep-deprived individuals. Studies that evaluated the 24-hour secretory pattern of IL-6 in healthy young adults suggest that IL-6 is secreted in a biphasic circadian pattern with two nadirs at about 08.00 and 21.00, and two zeniths at about 19.00 and 05.00 h. In contrast, following sleep deprivation or in disorders of sleep disturbance, e.g., insomnia, IL-6 peaks during the day and, based on the level of stress system activity, i.e., cortisol secretion, contributes to either sleepiness and deep sleep (low cortisol) or feelings of tiredness and fatigue and poor sleep (high cortisol). In order to address concerns about the potential impact of differences of IL-6 levels between the beginning and the end of the 24-hour blood-drawing experiment, we proceeded with a cosinor analysis of ‘detrended’ data in young and old healthy individuals. This new analysis did not affect the biphasic circadian pattern of IL-6 secretion in young adults, while it augmented the flattened circadian pattern in old individuals in whom the difference was greater. Finally, IL-6 appears to be somnogenic in rats and exhibits a diurnal rhythm that follows the sleep/wake cycle in these animals. We conclude that IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep.
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The proinflammatory cytokines IL-1, TNF-α, and IL-6 display a circadian pattern of secretion with peak levels correlating with feelings of sleepiness and sleep onset.
“The proinflammatory cytokines IL-1, TNF-α, and IL-6 display a circadian pattern of secretion with peak levels correlating with feelings of sleepiness and sleep onset (Imeri and Opp, 2009; Vgontzas et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Vgontzas et al., 2005
Cites
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012 · see citing works
Manolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,684 · see citing works
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K. D., Lotsikas, A. J., LIN, H., Kales, A., & Chrousos, G. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6484 · Cited by 1,196 · see citing works
Self-citationThe Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works
Self-citationAdverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Self-citationVgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
Self-citationVgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884 · see citing works
Self-citationGirasole, G., Jilka, R. L., Passeri, G., Boswell, S. H., Boder, G. B., Williams, D. C., & Manolagas, S. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115668 · Cited by 677 · see citing works
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591 · see citing works
Self-citationCircadian Interleukin-6 Secretion and Quantity and Depth of Sleep
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.-L., Licinio, J., Gold, P. W., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5894 · Cited by 516 · see citing works
Self-citationShearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
Vgontzas, A. N., & Chrousos, G. P. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00005-6 · Cited by 414 · see citing works
Self-citationSpäth‐Schwalbe, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.5.1573 · Cited by 377 · see citing works
Redwine, L. S., Hauger, R. L., Gillin, J. C., & Irwin, M. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6871 · Cited by 373 · see citing works
Vgontzas, A. N., Zoumakis, M., Papanicolaou, D. A., Bixler, E. O., Prolo, P., Lin, H.-M., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2002) · Metabolism · doi:10.1053/meta.2002.33357 · Cited by 329 · see citing works
Self-citationObesity Without Sleep Apnea Is Associated With Daytime Sleepiness
Vgontzas, A. N., Bixler, E. O., Tan, T. L., Kantner, D., Martin, L. F., & Kales, A. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.12.1333 · Cited by 329 · see citing works
Self-citationVgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., & Chrousos, G. P. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00763.x · Cited by 249 · see citing works
Self-citationEndocrinologic and metabolic effects of interleukin-6 in humans
Stouthard, J. M., Romijn, J. A., van der Poll, T., Endert, E., Klein, S., Bakker, P. J. M., Veenhof, C. H. N., & Sauerwein, H. P. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.5.e813 · Cited by 247 · see citing works
Vgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H.-M., Prolo, P., Vela‐Bueno, A., Kales, A., & Chrousos, G. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021176 · Cited by 235 · see citing works
Self-citationThe relationship of interleukin-1 and immune functions to sleep in humans.
Moldofsky, H., Lue, F. A., Eisen, J. S., Keystone, E., & Gorczynski, R. M. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198605000-00001 · Cited by 229 · see citing works
Dose-dependent effects of endotoxin on human sleep
Mullington, J., Korth, C., Hermann, D. M., Orth, A., Galanos, C., Holsboer, F., & Pollmächer, T. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r947 · Cited by 226 · see citing works
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 225 · see citing works
Self-citationThe relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat
Gool, J. V., van Vugt, H., Helle, M., & Aarden, L. A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90034-n · Cited by 179 · see citing works
Orban, Z., Remaley, A. T., Sampson, M. L., Trajanoski, Z., & Chrousos, G. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5747 · Cited by 174 · see citing works
Self-citationInterleukin-6: The Endocrine Cytokine
Papanicolaou, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6582 · Cited by 159 · see citing works
Nocturnal plasma levels of cytokines in healthy men
Gudewill, S., Pollmächer, T., Vedder, H., Schreiber, W., Fassbender, K. C., & Holsboer, F. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190343 · Cited by 145 · see citing works
Kapás, L., Hong, L., Cady, A. B., Opp, M. R., Postlethwaite, A. E., Seyer, J. M., & Krueger, J. M. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r708 · Cited by 143 · see citing works
Papanicolaou, D. A., Tsigos, C., Oldfield, E. H., & Chrousos, G. P. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964868 · Cited by 128 · see citing works
Self-citationDiurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures
Haack, M., Kraus, T., Schuld, A., Dalal, M. A., Koethe, D., & Pollmächer, T. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00006-9 · Cited by 113 · see citing works
Interleukin-6 alters sleep of rats
Hogan, D. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00038-9 · Cited by 112 · see citing works
Interleukin-6 is pyrogenic but not somnogenic
Opp, M. R., Obál, F., Cady, A. B., Johannsen, L., & Krueger, J. M. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90239-4 · Cited by 112 · see citing works
Boelen, A., Maas, M. A., Lowik, C. W., Platvoet, M. C., & Wiersinga, W. M. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940342 · Cited by 108 · see citing works
Circadian characteristics of circulating interleukin-6 in men
Sothern, R. B., Roitman-Johnson, B., Kanabrocki, E. L., Yager, J. G., Roodell, M. M., Weatherbee, J. A., Young, M. R. I., Nemchausky, B. M., & Scheving, L. E. (1995) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(95)70104-4 · Cited by 106 · see citing works
Torpy, D. J., Tsigos, C., Lotsikas, A. J., Defensor, R., Chrousos, G. P., & Papanicolaou, D. A. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90338-9 · Cited by 95 · see citing works
Self-citationCytokine Involvement in the Regulation of Sleep
Opp, M. R., Kapás, L., & Toth, L. A. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-201-43474 · Cited by 92 · see citing works
Exploring the cytokine and endocrine involvement in narcolepsy
Okun, M. L., Giese, S., Lin, L., Einen, M. A., Mignot, E. J.-M., & Coussons‐Read, M. E. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.002 · Cited by 89 · see citing works
Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle
Bauer, J., Hohagen, F., Ebert, T. H., Timmer, J., Ganter, U., Krieger, S., Lis, S., Postler, E., Voderholzer, U., & Berger, T. (1994) · Journal of Molecular Medicine · doi:10.1007/bf00180048 · Cited by 89 · see citing works
Small linear chloride channels are endogenous to nonepithelial cells
Gabriel, S. E., Price, E. M., Boucher, R. C., & Stutts, M. J. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.3.c708 · Cited by 88 · see citing works
Reincke, M., Heppner, C., Petzke, F. W., Allolio, B., Arlt, W., Mbulamberi, D., Siekmann, L., Vollmer, D., Winkelmann, W., & Chrousos, G. P. (2006) · NeuroImmunoModulation · doi:10.1159/000095930 · Cited by 69 · see citing works
Self-citationBreuninger, L. M., Dempsey, W. L., Uhl, J., & Murasko, D. M. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1171 · Cited by 61 · see citing works
In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls
Hinze‐Selch, D., Wetter, T. C., Zhang, Y., Lu, H. C., Albert, E. D., Mullington, J. M., Wekerle, H., Holsboer, F., & Pollmächer, T. (1998) · Neurology · doi:10.1212/wnl.50.4.1149 · Cited by 55 · see citing works
Interleukin-6 levels fluctuate with the light–dark cycle in the brain and peripheral tissues in rats
Guan, Z., Vgontzas, A. N., Omori, T., Peng, X., Bixler, E. O., & Fang, J. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.01.005 · Cited by 50 · see citing works
Self-citationHaack, M., Reichenberg, A., Kraus, T., Schuld, A., Yirmiya, R., & Pollmächer, T. (2000) · Cytokine · doi:10.1006/cyto.1999.0665 · Cited by 47 · see citing works
Guðmundsson, A., Ershler, W. B., Goodman, B., Lent, S. J., Barczi, S. R., & Carnes, M. L. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.11.2199 · Cited by 33 · see citing works
Cytokines and sleep: the first hundred years
Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.12.008 · Cited by 28 · see citing works
Seiler, W., Müller, H., & Hiemke, C. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.9.1778 · Cited by 28 · see citing works
Šereš, J., Herichová, I., Roman, O., Bornstein, S. R., & Jur̀čovičová, J. (2004) · NeuroImmunoModulation · doi:10.1159/000079412 · Cited by 16 · see citing works
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Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748 · see citing works
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Kyrou, I., Chrousos, G. P., & Tsigos, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.008 · Cited by 379 · see citing works
Self-citationMetabolic, Endocrine, and Immune Consequences of Sleep Deprivation
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Mertens‐Talcott, S. U., Jilma‐Stohlawetz, P., Rios, J., Hingorani, L., & Derendorf, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061674h · Cited by 353 · see citing works
Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
Hoge, E. A., Brandstetter, K., Moshier, S., Pollack, M. H., Wong, K. K., & Simon, N. M. (2009) · Depression and Anxiety · doi:10.1002/da.20564 · Cited by 343 · see citing works
Zhou, X., Fragala, M. S., McElhaney, J. E., & Kuchel, G. A. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cf3bc · Cited by 329 · see citing works
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The chronobiology, etiology and pathophysiology of obesity
Garaulet, M., Ordovás, J. M., & Madrid, J. A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.118 · Cited by 279 · see citing works
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Straub, R. H., & Cutolo, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22368 · Cited by 262 · see citing works
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Zisapel, N. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6529-9 · Cited by 216 · see citing works
Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. M., Bixler, E. O., Basta, M., Fang, J., Sarrigiannidis, A., & Chrousos, G. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00651.2005 · Cited by 194 · see citing works
Self-citationVgontzas, A. N. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802364627 · Cited by 191 · see citing works
Self-citationDooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
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Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165799 · Cited by 171 · see citing works
Pejovic, S., Basta, M., Vgontzas, A. N., Kritikou, I., Shaffer, M. L., Tsaoussoglou, M., Stiffler, D., Stefanakis, Z., Bixler, E. O., & Chrousos, G. P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2013 · Cited by 166 · see citing works
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Gray, S. M., & Bloch, M. H. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0272-0 · Cited by 162 · see citing works
Politis, M., Lahiri, N., Niccolini, F., Su, P., Wu, K., Giannetti, P., Scahill, R. I., Turkheimer, F., Tabrizi, S. J., & Piccini, P. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.011 · Cited by 156 · see citing works
Fernandez-Mendoza, J., Baker, J. H., Vgontzas, A. N., Gaines, J., Liao, D., & Bixler, E. O. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.026 · Cited by 155 · see citing works
Self-citationChennaoui, M., Desgorces, F.-D., Drogou, C., Boudjemaa, B., Tomaszewski, A., Depiesse, F., Burnat, P., Chalabi, H., & Gomez-Mérino, D. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-014 · Cited by 152 · see citing works
Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis
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Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147 · see citing works
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Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells
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Andersen, O., Eugen‐Olsen, J., Kofoed, K., Iversen, J., & Haugaard, S. B. (2007) · Journal of Medical Virology · doi:10.1002/jmv.21114 · Cited by 131 · see citing works
Schrepf, A., Clevenger, L., Christensen, D., DeGeest, K., Bender, D., Ahmed, A. I., Goodheart, M. J., Dahmoush, L., Penedo, F. J., Lucci, J. A., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.022 · Cited by 131 · see citing works
Vgontzas, A. N., Pejovic, S., Zoumakis, E., Lin, H. ‐., Bentley, C. M., Bixler, E. O., Sarrigiannidis, A., Basta, M., & Chrousos, G. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0774 · Cited by 129 · see citing works
Self-citationAbedelmalek, S., Chtourou, H., Aloui, A., Aouichaoui, C., Souissi, N., & Tabka, Z. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2432-7 · Cited by 128 · see citing works
Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations
Hurtado‐Alvarado, G., Pavón, L., Castillo-García, S. A., Hernández, M. E., Domı́nguez-Salazar, E., Velázquez‐Moctezuma, J., & Gómez‐González, B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/801341 · Cited by 128 · see citing works
Impaired Objective Daytime Vigilance in Obesity-Hypoventilation Syndrome
Chouri-Pontarollo, N., Borel, J., Tamisier, R., Wuyam, B., Levy, P. A., & Pépin, J. (2007) · CHEST Journal · doi:10.1378/chest.06-1159 · Cited by 125 · see citing works
Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis
Choy, E., & Calabrese, L. H. (2017) · Rheumatology · doi:10.1093/rheumatology/kex391 · Cited by 124 · see citing works
Short Communication: The Circadian Gene mPer2 Regulates the Daily Rhythm of IFN- γ
Arjona, A., & Sarkar, D. K. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.645 · Cited by 121 · see citing works
Selective effects of CPAP on sleep apnoea‐associated manifestations
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H., Collins, B., Basta, M., Pejovic, S., & Chrousos, G. P. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.01984.x · Cited by 117 · see citing works
Self-citationDisturbed sleep is associated with increased C-reactive protein in young women
Okun, M. L., Coussons‐Read, M. E., & Hall, M. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.008 · Cited by 117 · see citing works
Sleep enhances IL‐6 trans‐signaling in humans
Dimitrov, S., Lange, T., Benedict, C., Nowell, M. A., Jones, S. A., Scheller, J., Rose‐John, S., Born, J., Dimitrov, S., Lange, T., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5754fje · Cited by 115 · see citing works
Okun, M. L., Hall, M. H., & Coussons‐Read, M. E. (2007) · Reproductive Sciences · doi:10.1177/1933719107307647 · Cited by 115 · see citing works
Szabo, Y. Z., & Slavish, D. C. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105069 · Cited by 114 · see citing works
Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability
Bei, B., Seeman, T. E., Carroll, J., & Wiley, J. F. (2017) · SLEEP · doi:10.1093/sleep/zsx109 · Cited by 112 · see citing works
Etiology and site of temporal lobe epilepsy influence postictal cytokine release
Bauer, S., Cepok, S., Todorova-Rudolph, A., Nowak, M., Köller, M., Lorenz, R., Oertel, W. H., Rosenow, F., Hemmer, B., & Hamer, H. M. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.05.009 · Cited by 112 · see citing works
OSA and Cardiovascular Risk in Pediatrics
Smith, D. F., & Amin, R. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.02.011 · Cited by 111 · see citing works
Menstrual cycle symptoms are associated with changes in low‐grade inflammation
Puder, J. J., Blum, C. A., Müeller, B., Geyter, C. D., Dye, L., & Keller, U. B. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01591.x · Cited by 110 · see citing works
Prather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106 · see citing works
The hypothalamic clock and its control of glucose homeostasis
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 106 · see citing works
Perrin, L., Loizides‐Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux‐Lombard, P., Vidal, H., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.009 · Cited by 105 · see citing works
Inflammation and Sleep in Healthy Individuals
Mills, P. J., von Känel, R., Norman, D., Natarajan, L., Ziegler, M. G., & Dimsdale, J. E. (2007) · SLEEP · doi:10.1093/sleep/30.6.729 · Cited by 105 · see citing works
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.176 · Cited by 101 · see citing works
Sleep Dysfunction and Gastrointestinal Diseases.
Khanijow, V., Prakash, P., Emsellem, H. A., Borum, M. L., & Doman, D. B. (2015) · PubMed Central · Cited by 100 · see citing works
Klyne, D. M., Barbe, M. F., van den Hoorn, W., & Hodges, P. W. (2018) · European Spine Journal · doi:10.1007/s00586-018-5490-7 · Cited by 100 · see citing works
Obstructive sleep apnea syndrome is a systemic disease. Current evidence
Zamarrón, C., García-Paz, V., & Riveiro, A. (2008) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2007.12.006 · Cited by 100 · see citing works
Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
Clevenger, L., Schrepf, A., Christensen, D., DeGeest, K., Bender, D., Ahmed, A. I., Goodheart, M. J., Penedo, F. J., Lubaroff, D. M., Sood, A. K., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.04.003 · Cited by 99 · see citing works
Klyne, D. M., Barbe, M. F., & Hodges, P. W. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.10.003 · Cited by 95 · see citing works
Okun, M. L., Luther, J. F., Wisniewski, S. R., & Wisner, K. L. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829cc3e7 · Cited by 94 · see citing works
Cortisol awakening rise in middle-aged women in relation to psychological stress
O'Connor, D. B., Hendrickx, H., Dadd, T., Elliman, T. D., Willis, T. A., Talbot, D., Mayes, A. E., Thethi, K., Powell, J., & Dye, L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.002 · Cited by 94 · see citing works
Shimura, Y., Kurosawa, H., Sugawara, Y., Tsuchiya, M., Sawa, M., Kaneko, H., Futami, I., Liu, L., SADATSUKI, R., HADA, S., et al. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.05.014 · Cited by 91 · see citing works
Hoejberg, L., Bastholt, L., & Schmidt, H. (2012) · Melanoma Research · doi:10.1097/cmr.0b013e3283543d72 · Cited by 91 · see citing works
Abedelmalek, S., Souissi, N., Chtourou, H., Denguezli, M., Aouichaoui, C., Ajina, M. Z., Aloui, A., Dogui, M., Haddouk, S., & Tabka, Z. (2013) · Chronobiology International · doi:10.3109/07420528.2012.742102 · Cited by 90 · see citing works
Sleep and energy balance: interactive homeostatic systems
VanItallie, T. B. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.010 · Cited by 89 · see citing works
Circadian control of pain and neuroinflammation
Segal, J. P., Tresidder, K. A., Bhatt, C., Gilron, I., & Ghasemlou, N. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24150 · Cited by 89 · see citing works
Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints
Jarlborg, M., & Gabay, C. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155742 · Cited by 87 · see citing works
Acute effects of exposure to vapours of acetic acid in humans
Ernstgård, L., Iregren, A., Sjögren, B., & Johanson, G. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.01.010 · Cited by 87 · see citing works
The Efficacy of Hypericum perforatum (St Johnʼs Wort) for the Treatment of Premenstrual Syndrome
Canning, S. E., Waterman, M. G., Orsi, N. M., Ayres, J., Simpson, N., & Dye, L. (2010) · CNS Drugs · doi:10.2165/11530120-000000000-00000 · Cited by 86 · see citing works
Knudsen, L. S., Christensen, I. J., Lottenburger, T., Svendsen, M. N., Nielsen, H. J., Nielsen, L., Hørslev‐Petersen, K., Jensen, J. B., Kollerup, G., & Johansen, J. S. (2008) · Biomarkers · doi:10.1080/13547500701615017 · Cited by 86 · see citing works
Benedict, C., Scheller, J., Rose‐John, S., Jan Born, A., & Marshall, L. (2009) · The FASEB Journal · doi:10.1096/fj.08-122853 · Cited by 84 · see citing works
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
Coe, C. L., Love, G. D., Karasawa, M., Kawakami, N., Kitayama, S., Markus, H. R., Tracy, R. P., & Ryff, C. D. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.013 · Cited by 82 · see citing works
Obesity and sleep disturbances: Meaningful sub-typing of obesity
Vgontzas, A. N., Bixler, E. O., Chrousos, G. P., & Pejovic, S. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802521507 · Cited by 81 · see citing works
Self-citationGill, J., Luckenbaugh, D., Charney, D., & Vythilingam, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.033 · Cited by 80 · see citing works
Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?
Barnum, C. J., & Tansey, M. G. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0283-6 · Cited by 80 · see citing works
Monnet, E., Lapeyre, G., van Poelgeest, E. P., Jacqmin, P., de Graaf, K., Reijers, J. A. A., Moerland, M., Burggraaf, J., & de Min, C. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.522 · Cited by 79 · see citing works
Circadian disruption of ICU patients: A review of pathways, expression, and interventions
Korompeli, A., Muurlink, O. T., Kavrochorianou, N., Katsoulas, T. A., Fildissis, G., & Baltopoulos, G. J. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.12.006 · Cited by 78 · see citing works
Gaines, J., Vgontzas, A. N., Fernández‐Mendoza, J., Calhoun, S. L., He, F., Liao, D., Sawyer, M. D., & Bixler, E. O. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2016 · Cited by 78 · see citing works
Self-citationMentis, A.-F. A., Lee, D., & Roussos, P. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02047-6 · Cited by 75 · see citing works
Ruge, T., Lockton, J. A., Renström, F., Lystig, T., Sukonina, V., Svensson, M. K. E., & Eriksson, J. W. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.010 · Cited by 75 · see citing works
Savitz, J. B., Preskorn, S., Teague, T. K., Drevets, D. A., Yates, W. R., & Drevets, W. (2012) · BMJ Open · doi:10.1136/bmjopen-2011-000643 · Cited by 72 · see citing works
Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan
Chen, Y., Weng, S., Shen, Y., Chou, C., Yang, C.-Y., Wang, J., & Tien, K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1718 · Cited by 70 · see citing works
Braley, T. J., Chervin, R. D., & Segal, B. M. (2012) · Multiple Sclerosis International · doi:10.1155/2012/673936 · Cited by 68 · see citing works
Atzeni, F., Nucera, V., Masala, I. F., Sarzi‐Puttini, P., & Bonitta, G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104402 · Cited by 66 · see citing works
Oscillations in the immune system
Stark, J., Chan, C. C. W., & George, A. J. T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00501.x · Cited by 66 · see citing works
Daily Step Count Is Associated With Plasma C-Reactive Protein and IL-6 in a US Cohort With COPD
Moy, M. L., Teylan, M., Weston, N. A., GAGNON, D. R., Danilack, V. A., & Garshick, E. (2013) · CHEST Journal · doi:10.1378/chest.13-1052 · Cited by 65 · see citing works
Racial discrimination predicts greater systemic inflammation in pregnant African American women
Giurgescu, C., Engeland, C. G., Templin, T., Zenk, S. N., Koenig, M. D., & Garfield, L. (2016) · Applied Nursing Research · doi:10.1016/j.apnr.2016.06.008 · Cited by 65 · see citing works
Moons, W. G., & Shields, G. S. (2015) · Emotion · doi:10.1037/emo0000055 · Cited by 64 · see citing works
Agorastos, A., Hauger, R. L., Barkauskas, D. A., Moeller‐Bertram, T., Clopton, P., Haji, U., Lohr, J. B., Geracioti, T. D., Patel, P. M., Chrousos, G. P., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.020 · Cited by 64 · see citing works
Self-citationTrakada, G., Chrousos, G. P., Pejovic, S., & Vgontzas, A. N. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.003 · Cited by 64 · see citing works
Self-citationModerate blast exposure results in increased IL-6 and TNFα in peripheral blood
Gill, J., Motamedi, V., Osier, N. D., Dell, K. C., Arcurio, L. R., Carr, W. S., Walker, P., Ahlers, S. T., LoPresti, M. L., & Yarnell, A. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.015 · Cited by 63 · see citing works
The role of interleukins in preeclampsia: A comprehensive review
Bellos, I., Karageorgiou, V., Kapnias, D., Karamanli, K., & Siristatidis, C. S. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13055 · Cited by 63 · see citing works
Deenonpoe, R., Prayong, P., Thippamom, N., Meephansan, J., & Na‐Bangchang, K. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2535-3 · Cited by 62 · see citing works
Determinants of sleepiness in obstructive sleep apnea
Prasad, B., Steffen, A. D., Dongen, H. P. A. V., Pack, F. M., Strakovsky, I., Staley, B. A., Dinges, D. F., Maislin, G., Pack, A. I., & Weaver, T. E. (2018) · SLEEP · doi:10.1093/sleep/zsx199 · Cited by 61 · see citing works
Hermann, C., von Aulock, S., Dehus, O., Keller, M., Okigami, H., Gantner, F., Wendel, A., & Härtung, T. (2006) · European Journal of Immunology · doi:10.1002/eji.200535470 · Cited by 61 · see citing works
- Authors
- Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P.
- Affiliations
- Pennsylvania State University (US)
- University of California, Los Angeles (US)
- National Institutes of Health (US)
- Venue
- Neuroimmunomodulation
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 12
- Issue
- 3
- Pages
- 131-140
- ISSN
- 1021-7401 (ISSN-L)
- 1423-0216
- OpenAlex
- W1970138464
- Cited by
- 338
- References
- 47
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 10 · 2023: 20 · 2022: 14 · 2021: 7 · 2020: 19 · 2019: 22 · 2018: 12 · 2017: 19 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 20
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImmunoModulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- interleukin-6, circadian rhythm, sleepiness, sleep deprivation, narcolepsy, obstructive sleep apnea, obesity, insomnia, cortisol, aging, cosinor analysis, sleep homeostasis, rats
- MeSH terms
- Aging, Animals, Circadian Rhythm, Homeostasis, Humans, Hydrocortisone, Sleep, Sleep Wake Disorders, Species Specificity, Interleukin-6, Up-Regulation
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