Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone
Open accessAbstract
The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Another possible cause of female prevalence resides in the reported estradiol positive modulation of NMDAR activity, thus acting opposite to progestin positive GABAA modulation.
“Another possible cause of female prevalence resides in the reported estradiol positive modulation of NMDAR activity [142], thus acting opposite to progestin positive GABAA modulation.”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 65 · Cited by 25
Research works printed but not linked: 1
- [33]Kobayashi M Pascual-Leone A Blum AS Rutkove SB The Clinical Neurophysiology Primer 2007 New York Humana Press 499 515
- Authors
- Schloemer, N., Lenz, M., Tegenthoff, M., Dinse, H. R., & Höffken, O.
- Affiliations
- University of Cologne (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Corresponding author
- Dinse, Hubert R.
- Venue
- Scientific Reports
- Published
- 2020-12-17
- Volume
- 10
- Issue
- 1
- Pages
- 22237-22237
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7747729
- OpenAlex
- W3112510615
- Cited by
- 25
- References
- 65
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 3
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Dokumentenrepositorium der RUB (Ruhr University Bochum) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (ID 122679504 – SFB 874)
- Projekt DEAL
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- estradiol, progesterone, gonadal hormones, intracortical inhibition, somatosensory cortex, visual cortex, excitation-inhibition balance, menstrual cycle, somatosensory evoked potentials, visual evoked potentials, cortical excitability
- MeSH terms
- Adult, Estradiol, Evoked Potentials, Somatosensory, Evoked Potentials, Visual, Female, Humans, Male, Menstrual Cycle, Progesterone, Somatosensory Cortex, Visual Cortex, Gonadal Hormones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
