Serum biomarkers confirming stable remission in inflammatory bowel disease
Open accessAbstract
Crohn's disease (CD) and ulcerative colitis (UC) have a chronic-remittent course. Optimal management of inflammatory bowel diseases (IBD) relies on early intervention, treat-to-target strategies and a tight disease control. However, it is challenging to assess the risk of relapses in individual patients. We investigated blood-based biomarkers for the confirmation of disease remission in patients with IBD. We retrospectively analyzed samples of 40 IBD patients (30 UC, 10 CD) enrolled in a tight-control follow-up study. Half of the patients had a flare during follow up. Serum was analyzed for S100A12 as well as S100A8/A9 and for 50 further biomarkers in a bead-based multiplex assay. The concentrations of 9 cytokines/chemokines and S100A8/A9 significantly differed in IBD patients with unstable remission (before flares) when compared to IBD patients with stable remission. Although the number of patients was small, ROC curve analyses revealed a number of biomarkers (IL-1β, IL-1RA, IL-8, IL13, IL-15, IL-21, IL-25, IFN-β, CXCL9, CXCL10, CXCL11, Galectin-1, G-CSF and S100A8/A9) that were elevated in patients with later occurring relapses. While earlier studies on peripheral biomarkers in IBD are limited to only few analytes, our study using a broad screening approach identified serum biomarkers with the potential to indicate unstable disease control in IBD, which may help to steer individual therapies to maintain remission.
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S100A8/A9 is recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis.
“Importantly, S100A8/A9 has been recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis [16–18].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [17]
The Results (page unavailable) identify S100A8/A9 as a marker distinguishing ulcerative colitis patients with future flares from those with stable remission, supporting its biomarker role in that setting. The paper does not address whether S100A8/A9 promotes inflammation-associated tumorigenesis. (LLM, conf=0.88)
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- Authors
- Kessel, C., Lavric, M., Weinhage, T., Brueckner, M., de Roock, S., Däbritz, J., Weber, J., Vastert, S. J., & Foell, D.
- Affiliations
- University Hospital Münster (DE)
- Universitätsmedizin Rostock (DE)
- Bühlmann (Switzerland) (CH)
- University Medical Center Utrecht (NL)
- Corresponding author
- Foell, Dirk
- Venue
- Scientific Reports
- Published
- 2021-03-23
- Volume
- 11
- Issue
- 1
- Pages
- 6690-6690
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7988138
- OpenAlex
- W3136572860
- Cited by
- 54
- References
- 36
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 12 · 2023: 12 · 2022: 7 · 2021: 6
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- URN:NBN Resolver for Germany & Switzerland (German National Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Universitäts- und Landesbibliothek Münster (cc-by)
- Funders
- EU FP7 (305266 ‘MIAMI’)
- Crohn’s and Colitis Foundation of America (CCFA ref. no. 1911)
- Westfälische Wilhelms-Universität Münster
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, serum biomarkers, remission, recurrence prediction, S100A8/A9, S100A12, cytokines, chemokines, galectin-1, granulocyte colony-stimulating factor, treat-to-target, multiplex bead assay
- MeSH terms
- Adult, Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Prognosis, ROC Curve, Severity of Illness Index, Inflammatory Bowel Diseases, Biomarkers, Cytokines, Inflammation Mediators, Computational Biology, Proteome, Proteomics
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