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Cited by 10Sports Performance and TrainingMuscle metabolism and nutritionThermoregulation and physiological responses

The interplay between bicarbonate kinetics and gastrointestinal upset on ergogenic potential after sodium bicarbonate intake: a randomized double-blind placebo-controlled trial

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Durkalec-Michalski, Krzysztof, Nowaczyk, Paulina M., Kamińska, Joanna, Saunders, Bryan, Łoniewski, Igor, Czubaszek, Dominika, Steffl, Michal, Podgórski, Tomasz·2023·Scientific Reports
DOI 10.1038/s41598-023-34343-0PMC PMC10151363
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Abstract

This double-blind placebo-controlled cross-over study utilized comprehensive monitoring of blood bicarbonate (HCO 3¯) kinetics and evaluation of gastrointestinal (GI) upset to determine their impact on an ergogenic potential of sodium bicarbonate (SB) co-ingested with carbohydrate (CHO). Nineteen CrossFit athletes performed 6 bouts of 15 s Wingate Anaerobic Test (WAnT) 90 min post-ingestion of 0.4 g·kg−1 body mass (BM) of SB (SB + CHO treatment) or PLA (PLA + CHO treatment) with 15 g CHO. Blood HCO 3¯ concentration was evaluated at baseline, 30-, 60-, 75- and 90 min post-ingestion, in between WAnT bouts, and 3 and 45 min post-exercise, while GI upset at 120 min after protocol started. Control (no supplementation; CTRL) procedures were also performed. An effective elevation of extra-cellular buffering capacity was observed 60–90 min post-ingestion of SB + CHO. At mean peak blood HCO 3¯, or at start of exercise an increase > 6 mmol·L−1 in HCO 3¯ was noted in 84% and 52.6% participants, respectively. SB + CHO did not prevent performance decrements in WAnT bouts. There were no significant relationships between changes in blood HCO 3¯ and WAnTs’ performance. Total GI was significantly higher in SB + CHO compared to CTRL, and stomach problems in SB + CHO compared to CTRL and PLA + CHO. There were inverse associations between peak- (p = 0.031; r = − 0.495), average- (p = 0.002; r = − 0.674) and minimum power (p = 0.008; r = − 0.585) and total GI upset, as well as average power and severe GI distress (p = 0.042; r = − 0.471) at SB + CHO. The implemented dose of SB + CHO was effective in improving buffering capacity, but did not prevent decrements in WAnTs’ performance. GI side effects were crucial in affecting the ergogenic potential of SB and thus must be insightfully monitored in future studies.

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Authors
Durkalec-Michalski, K., Nowaczyk, P. M., Kamińska, J., Saunders, B., Łoniewski, I., Czubaszek, D., Steffl, M., & Podgórski, T.
Affiliations
  • Universidade de São Paulo (BR)
  • Pomeranian Medical University (PL)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2023-05-01
Volume
13
Issue
1
Pages
7081-7081
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-023-34343-0
PMC
PMC10151363
OpenAlex
W4367599426
Cited by
10
References
45
Citations by year
2026: 5 · 2025: 4 · 2024: 1
FWCI
2.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Narodowe Centrum Nauki (2018/02/X/NZ7/03217)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Keywords
sodium bicarbonate, gastrointestinal upset, ergogenic aids, buffering capacity, anaerobic performance, Wingate test, CrossFit athletes
MeSH terms
Bicarbonates, Double-Blind Method, Gastrointestinal Diseases, Humans, Polyesters, Sodium Bicarbonate, Cross-Over Studies, Athletic Performance

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