Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men
Open accessAbstract
BACKGROUND: Sodium bicarbonate intake has been shown to improve exercise tolerance, but the effects on high-intensity intermittent exercise are less clear. Thus, the aim of the present study was to determine the effect of sodium bicarbonate intake on Yo-Yo intermittent recovery test level 2 performance in trained young men. METHOD: Thirteen men aged 23 ± 1 year (height: 180 ± 2 cm, weight: 78 ± 3 kg; VO2max: 61.3 ± 3.3 mlO2 · kg(-1) · min(-1); means ± SEM) performed the Yo-Yo intermittent recovery test level 2 (Yo-Yo IR2) on two separate occasions in randomized order with (SBC) and without (CON) prior intake of sodium bicarbonate (0.4 g · kg(-1) body weight). Heart rate and rating of perceived exertion (RPE) were measured during the test and venous blood samples were taken frequently. RESULTS: Yo-Yo IR2 performance was 14 % higher (P = 0.04) in SBC than in CON (735 ± 61 vs 646 ± 46 m, respectively). Blood pH and bicarbonate were similar between trials at baseline, but higher (P = 0.003) immediately prior to the Yo-Yo IR2 test in SBC than in CON (7.44 ± 0.01 vs 7.32 ± 0.01 and 33.7 ± 3.2 vs 27.3 ± 0.6 mmol · l(-1), respectively). Blood lactate was 0.9 ± 0.1 and 0.8 ± 0.1 mmol · l(-1) at baseline and increased to 11.3 ± 1.4 and 9.4 ± 0.8 mmol · l(-1) at exhaustion in SBC and CON, respectively, being higher (P = 0.03) in SBC. Additionally, peak blood lactate was higher (P = 0.02) in SBC than in CON (11.7 ± 1.2 vs 10.2 ± 0.7 mmol · l(-1)). Blood glucose, plasma K(+) and Na(+) were not different between trials. Peak heart rate reached at exhaustion was 197 ± 3 and 195 ± 3 bpm in SBC and CON, respectively, with no difference between conditions. RPE was 7% lower (P = 0.003) in SBC than in CON after 440 m, but similar at exhaustion (19.3 ± 0.2 and 19.5 ± 0.2). CONCLUSION: In conclusion, high-intensity intermittent exercise performance is improved by prior intake of sodium bicarbonate in trained young men, with concomitant elevations in blood alkalosis and peak blood lactate levels, as well as lowered rating of perceived exertion.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A controlled, crossover, randomized study with 12 soccer players found that 6 mg/kg BW caffeine 1 h before the test improved time to hit a penalty and countermovement jump performance.
“A controlled, crossover, randomized study with 12 soccer players evaluated 6 mg kg -1 BW caffeine 1 h before the test and found improvements in time to hit a penalty and performance in the countermovement jump [17].”
From Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance (2021) · cites this paper as [17]
The Methods (Design and Supplementation; page unavailable) describe a randomized crossover test of sodium bicarbonate versus no supplement, not caffeine; participants were instructed to avoid caffeine before testing. The measured performance outcome was the Yo-Yo intermittent recovery test, not penalty-hit time or countermovement jumps. (LLM, conf=0.90)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cellular mechanisms of muscle fatigue
Fitts, R. H. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.49 · Cited by 1,537 · see citing works
Muscle and Blood Metabolites during a Soccer Game: Implications for Sprint Performance
KRUSTRUP, P., MOHR, M., STEENSBERG, A., BENCKE, J., KJÆR, M., & BANGSBO, J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000222845.89262.cd · Cited by 742 · see citing works
Self-citationMohr, M., Nielsen, J. J., & Bangsbo, J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01028.2010 · Cited by 162 · see citing works
Self-citationEffect of sodium bicarbonate on [HCO3-], pH, and gastrointestinal symptoms
Carr, A. J., Slater, G. J., Gore, C. J., Dawson, B., & Burke, L. M. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.3.189 · Cited by 159 · see citing works
Effects of induced metabolic alkalosis on prolonged intermittent-sprint performance
BISHOP, D., & CLAUDIUS, B. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000161803.44656.3c · Cited by 155 · see citing works
β-alanine supplementation improves YoYo intermittent recovery test performance
Saunders, B., Sunderland, C., Harris, R. C., & Sale, C. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-39 · Cited by 54 · see citing works
Flagged first, then by citations
Research works printed but not linked: 27
- [2]Keyser RE Peripheral fatigue: high-energy phosphates and hydrogen ions PM R 2010 2 347 58 10.1016/j.pmrj.2010.04.009 20656616 · DOI
- [3]Nordsborg N Mohr M Pedersen LD Nielsen JJ Langberg H Bangsbo J Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise Am J Physiol Regul Integr Comp Physiol 2003 285 143 8 10.1152/ajpregu.00029.2003 12663256 · DOI
- [4]Mohr M Nordsborg N Nielsen JJ Pedersen LD Fischer C Krustrup P Bangsbo J Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue Pflugers Arch 2004 448 452 6 10.1007/s00424-004-1257-6 15048574 · DOI
- [6]Bendiksen M Bischoff R Randers MB Mohr M Rollo I Suetta C Nielsen JJ Bangsbo J Krustrup P The Copenhagen Soccer Test: Physiological Responses and Fatigue Development Med Sci Sport Exerc 2012 44 1595 603 10.1249/MSS.0b013e31824cc23b 22330015 · DOI
- [7]Krustrup P Mohr M Nybo L Jensen JM Nielsen JJ Bangsbo J The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer Med Sci Sports Exerc 2006 38 1666 73 10.1249/01.mss.0000227538.20799.08 16960529 · DOI
- [8]Bangsbo J, Iaia FM, Krustrup P. The Yo-Yo intermittent recovery test: a useful tool for evaluation of physical performance in intermittent sports. Sports Med, 2008;38:37-51 18081366
- [9]Kilding AE Overton C Gleave J Effects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance Int J Sport Nutr Exerc Metab 2012 22 175 83 22693238
- [10]Culbertson JY Kreider RB Greenwood M Cooke M Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature Nutr 2010 2 75 98 PMC3257613 22253993
- [11]Bangsbo J Madsen K Kiens B Richter EA Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man J Physiol 1996 495 587 96 10.1113/jphysiol.1996.sp021618 8887768 PMC1160816 · DOI
- [12]Harris RC Sale C Beta-alanine supplementation in high-intensity exercise Med Sport Sci 2012 59 1 17 23075550
- [13]Burke LM Practical considerations for bicarbonate loading and sports performance Nestle Nutr Inst Workshop Ser 2013 75 15 26 23765347
- [14]Peart DJ Siegler JC Vince RV Practical recommendations for coaches and athletes: a meta-analysis of sodium bicarbonate use for athletic performance J Strength Cond Res 2012 26 1975 83 10.1519/JSC.0b013e3182576f3d 22505127 · DOI
- [17]Siegler JC Hirscher K Sodium bicarbonate ingestion and boxing performance J Strength Cond Res 2010 24 103 8 10.1519/JSC.0b013e3181a392b2 19625976 · DOI
- [20]Mohr M Krustrup P Nielsen JJ Nybo L Rasmussen MK Juel C Bangsbo J Effect of two different intense training regimes on skeletal muscle ion transport systems and fatigue development Am J Physiol Regul Interg Comp Physiol 2007 292 R1594 602 10.1152/ajpregu.00251.2006 17194727 · DOI
- [22]Juel C Klarskov C Nielsen JJ Krustrup P Mohr M Bangsbo J Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle Am J Physiol Endocrinol Metab 2004 286 e245 51 10.1152/ajpendo.00303.2003 14559724 · DOI
- [24]Iaia FM Thomassen M Kolding H Gunnarsson T Wendell J Rostgaard T Nordsborg N Krustrup P Nybo L Hellsten Y Bangsbo J Reduced volume but increased training intensity elevates muscle Na + -K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans Am J Physiol Regul Integr Comp Physiol 2008 294 R966 74 10.1152/ajpregu.00666.2007 18094063 · DOI
- [25]Bishop D Edge J Davis C Goodman C Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability Med Sci Sports Exerc 2004 36 807 13 10.1249/01.MSS.0000126392.20025.17 15126714 · DOI · Paper page
- [26]Pollo A Carlino E Benedetti F Placebo mechanisms across different conditions: from clinical settings to physical performance Phil Trans R Soc B 2011 366 1790 8 10.1098/rstb.2010.0381 21576136 PMC3130395 · DOI
- [27]Street D Nielsen JJ Bangsbo J Juel C Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium J Physiol 2005 566 481 9 10.1113/jphysiol.2005.086801 15860529 PMC1464741 · DOI
- [28]McKenna MJ Bangsbo J Renaud JM Muscle K+, Na+, and Cl disturbances and Na + -K+ pump inactivation: implications for fatigue J Appl Physiol 1985 104 288 95 10.1152/japplphysiol.01037.2007 17962569 · DOI
- [29]Cairns SP Lindinger MI Do multiple ionic interactions contribute to skeletal muscle fatigue J Physiol 2008 586 4039 54 10.1113/jphysiol.2008.155424 18591187 PMC2652190 · DOI
- [30]Juel C Pilegaard H Nielsen JJ Bangsbo J Interstitial K(+) in human skeletal muscle during and after dynamic graded exercise determined by microdialysis Am J Physiol Regul Integr Comp Physiol 2000 278 R400 6 10666141
- [31]Clausen T Na+-K+ pump regulation and skeletal muscle contractility Physiol Rev 2003 83 1269 324 10.1152/physrev.00011.2003 14506306 · DOI
- [32]Davis NW Standen NB Stanfield PR ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions J Bioenerg Biomembr 1991 23 509 35 10.1007/BF00785809 1917907 · DOI
- [33]Gandevia SC Spinal and supraspinal factors in human muscle fatigue Physiol Rev 2001 81 1725 89 11581501
- [34]Amann M Sidhu SK Weavil JC Mangum TS Venturelli M Autonomic responses to exercise: Group III/IV muscle afferents and fatigue Auton Neurosci 2014 188 19 23 10.1016/j.autneu.2014.10.018 25458423 PMC4336599 · DOI
- [35]Nybo L Secher NH Cerebral perturbations provoked by prolonged exercise Prog Neurobiol 2004 72 223 61 10.1016/j.pneurobio.2004.03.005 15142684 · DOI · Paper page
Cited by
Sorted by citations
Evidence-based supplements for the enhancement of athletic performance
Peeling, P., Binnie, M. J., Goods, P. S. R., Sim, M., & Burke, L. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0343 · Cited by 225 · see citing works
Grgic, J., Pedisic, Z., Saunders, B., Artioli, G. G., Schoenfeld, B. J., McKenna, M. J., Bishop, D. J., Kreider, R. B., Stout, J. R., Kalman, D. S., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00458-w · Cited by 138 · see citing works
Peeling, P., Castell, L. M., Derave, W., de Hon, O., & Burke, L. M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0271 · Cited by 116 · see citing works
Heibel, A. B., Perim, P. H. L., Oliveira, L. F., McNaughton, L. R., & Saunders, B. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00035 · Cited by 92 · see citing works
Portuguese Football Federation consensus statement 2020: nutrition and performance in football
Abreu, R., Figueiredo, P., Beckert, P., Marques, J. P., Amorim, S., Caetano, C., Carvalho, P., Sá, C., Cotovio, R., Cruz, J., et al. (2021) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2021-001082 · Cited by 38 · see citing works
Macutkiewicz, D., & Sunderland, C. (2018) · Physiological Reports · doi:10.14814/phy2.13818 · Cited by 26 · see citing works
Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance
Fernandes, H. (2021) · Annals of Nutrition and Metabolism · doi:10.1159/000516397 · Cited by 12 · see citing works
RetractedMarcus, A., Rossi, A., Cornwell, A., Hawkins, S. A., & Khodiguian, N. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0309-4 · Cited by 5 · see citing works
Jiang, F.-L., Jeong, D.-H., Eom, S.-H., Lee, H.-M., Cha, B.-J., Park, J.-S., Kwon, R., Nam, J.-Y., Yu, H.-S., Heo, S.-H., et al. (2024) · Nutrients · doi:10.3390/nu16050744 · Cited by 4 · see citing works
Gurton, W. H., Gough, L. A., Lynn, A., & Ranchordas, M. K. (2025) · Nutrients · doi:10.3390/nu17213383 · Cited by 4 · see citing works
Zhou, N., Fan, Y., Kong, X., Wang, X., Wang, J., & Wu, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931671 · Cited by 3 · see citing works
- Authors
- Krustrup, P., Ermidis, G., & Mohr, M.
- Affiliations
- University of Copenhagen (DK)
- Democrite University of Thrace 69100 Komotini Greece
- University of the Faroe Islands (FO)
- Corresponding author
- Mohr, Magni
- Venue
- Journal of the International Society of Sports Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-10-20
- Volume
- 12
- Issue
- 1
- Pages
- 25-25
- ISSN
- 1550-2783 (ISSN-L)
- PMC
- PMC4475610
- OpenAlex
- W2110813619
- Cited by
- 74
- References
- 6
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 2
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sodium bicarbonate supplementation, high-intensity intermittent exercise, blood lactate, blood pH, bicarbonate, exercise performance, heart rate, rating of perceived exertion, blood glucose, plasma potassium, plasma sodium, exercise tolerance, buffering capacity, anaerobic capacity
- MeSH terms
- Alkalosis, Blood Glucose, Body Weight, Physical Exertion, Fatigue, Heart Rate, Humans, Hydrogen-Ion Concentration, Male, Physical Endurance, Potassium, Sodium, Single-Blind Method, Sodium Bicarbonate, Cross-Over Studies, Lactic Acid, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review