Cited by 74Sports Performance and TrainingCardiovascular and exercise physiologyMuscle metabolism and nutrition

Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men

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Krustrup, Peter, Ermidis, Georgios, Mohr, Magni·2015·Journal of the International Society of Sports Nutrition

Abstract

BACKGROUND: Sodium bicarbonate intake has been shown to improve exercise tolerance, but the effects on high-intensity intermittent exercise are less clear. Thus, the aim of the present study was to determine the effect of sodium bicarbonate intake on Yo-Yo intermittent recovery test level 2 performance in trained young men. METHOD: Thirteen men aged 23 ± 1 year (height: 180 ± 2 cm, weight: 78 ± 3 kg; VO2max: 61.3 ± 3.3 mlO2 · kg(-1) · min(-1); means ± SEM) performed the Yo-Yo intermittent recovery test level 2 (Yo-Yo IR2) on two separate occasions in randomized order with (SBC) and without (CON) prior intake of sodium bicarbonate (0.4 g · kg(-1) body weight). Heart rate and rating of perceived exertion (RPE) were measured during the test and venous blood samples were taken frequently. RESULTS: Yo-Yo IR2 performance was 14 % higher (P = 0.04) in SBC than in CON (735 ± 61 vs 646 ± 46 m, respectively). Blood pH and bicarbonate were similar between trials at baseline, but higher (P = 0.003) immediately prior to the Yo-Yo IR2 test in SBC than in CON (7.44 ± 0.01 vs 7.32 ± 0.01 and 33.7 ± 3.2 vs 27.3 ± 0.6 mmol · l(-1), respectively). Blood lactate was 0.9 ± 0.1 and 0.8 ± 0.1 mmol · l(-1) at baseline and increased to 11.3 ± 1.4 and 9.4 ± 0.8 mmol · l(-1) at exhaustion in SBC and CON, respectively, being higher (P = 0.03) in SBC. Additionally, peak blood lactate was higher (P = 0.02) in SBC than in CON (11.7 ± 1.2 vs 10.2 ± 0.7 mmol · l(-1)). Blood glucose, plasma K(+) and Na(+) were not different between trials. Peak heart rate reached at exhaustion was 197 ± 3 and 195 ± 3 bpm in SBC and CON, respectively, with no difference between conditions. RPE was 7% lower (P = 0.003) in SBC than in CON after 440 m, but similar at exhaustion (19.3 ± 0.2 and 19.5 ± 0.2). CONCLUSION: In conclusion, high-intensity intermittent exercise performance is improved by prior intake of sodium bicarbonate in trained young men, with concomitant elevations in blood alkalosis and peak blood lactate levels, as well as lowered rating of perceived exertion.

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  • A controlled, crossover, randomized study with 12 soccer players found that 6 mg/kg BW caffeine 1 h before the test improved time to hit a penalty and countermovement jump performance.

    “A controlled, crossover, randomized study with 12 soccer players evaluated 6 mg kg -1 BW caffeine 1 h before the test and found improvements in time to hit a penalty and performance in the countermovement jump [17].”

    From Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance (2021) · cites this paper as [17]

    The Methods (Design and Supplementation; page unavailable) describe a randomized crossover test of sodium bicarbonate versus no supplement, not caffeine; participants were instructed to avoid caffeine before testing. The measured performance outcome was the Yo-Yo intermittent recovery test, not penalty-hit time or countermovement jumps. (LLM, conf=0.90)

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  1. [2]Keyser RE Peripheral fatigue: high-energy phosphates and hydrogen ions PM R 2010 2 347 58 10.1016/j.pmrj.2010.04.009 20656616 · DOI
  2. [3]Nordsborg N Mohr M Pedersen LD Nielsen JJ Langberg H Bangsbo J Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise Am J Physiol Regul Integr Comp Physiol 2003 285 143 8 10.1152/ajpregu.00029.2003 12663256 · DOI
  3. [4]Mohr M Nordsborg N Nielsen JJ Pedersen LD Fischer C Krustrup P Bangsbo J Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue Pflugers Arch 2004 448 452 6 10.1007/s00424-004-1257-6 15048574 · DOI
  4. [6]Bendiksen M Bischoff R Randers MB Mohr M Rollo I Suetta C Nielsen JJ Bangsbo J Krustrup P The Copenhagen Soccer Test: Physiological Responses and Fatigue Development Med Sci Sport Exerc 2012 44 1595 603 10.1249/MSS.0b013e31824cc23b 22330015 · DOI
  5. [7]Krustrup P Mohr M Nybo L Jensen JM Nielsen JJ Bangsbo J The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer Med Sci Sports Exerc 2006 38 1666 73 10.1249/01.mss.0000227538.20799.08 16960529 · DOI
  6. [8]Bangsbo J, Iaia FM, Krustrup P. The Yo-Yo intermittent recovery test: a useful tool for evaluation of physical performance in intermittent sports. Sports Med, 2008;38:37-51 18081366
  7. [9]Kilding AE Overton C Gleave J Effects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance Int J Sport Nutr Exerc Metab 2012 22 175 83 22693238
  8. [10]Culbertson JY Kreider RB Greenwood M Cooke M Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature Nutr 2010 2 75 98 PMC3257613 22253993
  9. [11]Bangsbo J Madsen K Kiens B Richter EA Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man J Physiol 1996 495 587 96 10.1113/jphysiol.1996.sp021618 8887768 PMC1160816 · DOI
  10. [12]Harris RC Sale C Beta-alanine supplementation in high-intensity exercise Med Sport Sci 2012 59 1 17 23075550
  11. [13]Burke LM Practical considerations for bicarbonate loading and sports performance Nestle Nutr Inst Workshop Ser 2013 75 15 26 23765347
  12. [14]Peart DJ Siegler JC Vince RV Practical recommendations for coaches and athletes: a meta-analysis of sodium bicarbonate use for athletic performance J Strength Cond Res 2012 26 1975 83 10.1519/JSC.0b013e3182576f3d 22505127 · DOI
  13. [17]Siegler JC Hirscher K Sodium bicarbonate ingestion and boxing performance J Strength Cond Res 2010 24 103 8 10.1519/JSC.0b013e3181a392b2 19625976 · DOI
  14. [20]Mohr M Krustrup P Nielsen JJ Nybo L Rasmussen MK Juel C Bangsbo J Effect of two different intense training regimes on skeletal muscle ion transport systems and fatigue development Am J Physiol Regul Interg Comp Physiol 2007 292 R1594 602 10.1152/ajpregu.00251.2006 17194727 · DOI
  15. [22]Juel C Klarskov C Nielsen JJ Krustrup P Mohr M Bangsbo J Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle Am J Physiol Endocrinol Metab 2004 286 e245 51 10.1152/ajpendo.00303.2003 14559724 · DOI
  16. [24]Iaia FM Thomassen M Kolding H Gunnarsson T Wendell J Rostgaard T Nordsborg N Krustrup P Nybo L Hellsten Y Bangsbo J Reduced volume but increased training intensity elevates muscle Na + -K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans Am J Physiol Regul Integr Comp Physiol 2008 294 R966 74 10.1152/ajpregu.00666.2007 18094063 · DOI
  17. [25]Bishop D Edge J Davis C Goodman C Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability Med Sci Sports Exerc 2004 36 807 13 10.1249/01.MSS.0000126392.20025.17 15126714 · DOI · Paper page
  18. [26]Pollo A Carlino E Benedetti F Placebo mechanisms across different conditions: from clinical settings to physical performance Phil Trans R Soc B 2011 366 1790 8 10.1098/rstb.2010.0381 21576136 PMC3130395 · DOI
  19. [27]Street D Nielsen JJ Bangsbo J Juel C Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium J Physiol 2005 566 481 9 10.1113/jphysiol.2005.086801 15860529 PMC1464741 · DOI
  20. [28]McKenna MJ Bangsbo J Renaud JM Muscle K+, Na+, and Cl disturbances and Na + -K+ pump inactivation: implications for fatigue J Appl Physiol 1985 104 288 95 10.1152/japplphysiol.01037.2007 17962569 · DOI
  21. [29]Cairns SP Lindinger MI Do multiple ionic interactions contribute to skeletal muscle fatigue J Physiol 2008 586 4039 54 10.1113/jphysiol.2008.155424 18591187 PMC2652190 · DOI
  22. [30]Juel C Pilegaard H Nielsen JJ Bangsbo J Interstitial K(+) in human skeletal muscle during and after dynamic graded exercise determined by microdialysis Am J Physiol Regul Integr Comp Physiol 2000 278 R400 6 10666141
  23. [31]Clausen T Na+-K+ pump regulation and skeletal muscle contractility Physiol Rev 2003 83 1269 324 10.1152/physrev.00011.2003 14506306 · DOI
  24. [32]Davis NW Standen NB Stanfield PR ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions J Bioenerg Biomembr 1991 23 509 35 10.1007/BF00785809 1917907 · DOI
  25. [33]Gandevia SC Spinal and supraspinal factors in human muscle fatigue Physiol Rev 2001 81 1725 89 11581501
  26. [34]Amann M Sidhu SK Weavil JC Mangum TS Venturelli M Autonomic responses to exercise: Group III/IV muscle afferents and fatigue Auton Neurosci 2014 188 19 23 10.1016/j.autneu.2014.10.018 25458423 PMC4336599 · DOI
  27. [35]Nybo L Secher NH Cerebral perturbations provoked by prolonged exercise Prog Neurobiol 2004 72 223 61 10.1016/j.pneurobio.2004.03.005 15142684 · DOI · Paper page

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Authors
Krustrup, P., Ermidis, G., & Mohr, M.
Affiliations
  • University of Copenhagen (DK)
  • Democrite University of Thrace 69100 Komotini Greece
  • University of the Faroe Islands (FO)
Corresponding author
Mohr, Magni
Venue
Journal of the International Society of Sports Nutrition
Published
2015-10-20
Volume
12
Issue
1
Pages
25-25
ISSN
1550-2783 (ISSN-L)
OpenAlex
W2110813619
Cited by
74
References
6
Citations by year
2026: 6 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 2
FWCI
8.95
Type
journal article
Language
en
Open access
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
sodium bicarbonate supplementation, high-intensity intermittent exercise, blood lactate, blood pH, bicarbonate, exercise performance, heart rate, rating of perceived exertion, blood glucose, plasma potassium, plasma sodium, exercise tolerance, buffering capacity, anaerobic capacity
MeSH terms
Alkalosis, Blood Glucose, Body Weight, Physical Exertion, Fatigue, Heart Rate, Humans, Hydrogen-Ion Concentration, Male, Physical Endurance, Potassium, Sodium, Single-Blind Method, Sodium Bicarbonate, Cross-Over Studies, Lactic Acid, Young Adult

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