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Cancer incidence trends in New York State and associations with common population-level exposures 2010–2018: an ecological study

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Yuan, Haokun, Kehm, Rebecca D., Daaboul, Josephine M., Lloyd, Susan E., McDonald, Jasmine A., Mu, Lina, Tehranifar, Parisa, Zhang, Kai +2 more·2024·Scientific Reports
DOI 10.1038/s41598-024-56634-wPMC PMC10966002
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Abstract

The impact of common environmental exposures in combinations with socioeconomic and lifestyle factors on cancer development, particularly for young adults, remains understudied. Here, we leveraged environmental and cancer incidence data collected in New York State at the county level to examine the association between 31 exposures and 10 common cancers (i.e., lung and bronchus, thyroid, colorectal, kidney and renal pelvis, melanoma, non-Hodgkin lymphoma, and leukemia for both sexes; corpus uteri and female breast cancer; prostate cancer), for three age groups (25–49, 50–69, and 70–84 year-olds). For each cancer, we stratified by age group and sex, and applied regression models to examine the associations with multiple exposures simultaneously. The models included 642,013 incident cancer cases during 2010–2018 and found risk factors consistent with previous reports (e.g., smoking and physical inactivity). Models also found positive associations between ambient air pollutants (ozone and PM 2.5) and prostate cancer, female breast cancer, and melanoma of the skin across multiple population strata. Additionally, the models were able to better explain the variation in cancer incidence data among 25–49 year-olds than the two older age groups. These findings support the impact of common environmental exposures on cancer development, particularly for younger age groups.

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  • Yuan et al. reported a significant association between PM2.5, black carbon, and NO3- and melanoma in different age groups of men in New York, USA.

    “the study by Yuan et al. [83] reported a significant association between PM2.5, black carbon, and NO3- and melanoma in different age groups of men in New York, USA.”

    From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [83]

    The Results section reports statistically significant associations between PM2.5-related variables and melanoma of the skin in men, and describes an association with the PM2.5 mineral-dust component across age groups. The passages available from our copy do not establish the claimed melanoma associations for black carbon or NO3−; Table 1 instead lists black carbon (BC) in a model for thyroid cancer in men aged 25–49. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Yuan, H., Kehm, R. D., Daaboul, J. M., Lloyd, S. E., McDonald, J. A., Mu, L., Tehranifar, P., Zhang, K., Terry, M. B., & Yang, W.
Affiliations
  • Columbia University (US)
  • Columbia University Irving Medical Center (US)
  • University at Buffalo, State University of New York (US)
  • State University of New York (US)
Corresponding author
Yang, Wan
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2024-03-26
Volume
14
Issue
1
Pages
7141-7141
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-024-56634-w
PMC
PMC10966002
OpenAlex
W4393192757
Cited by
9
References
2
Citations by year
2026: 3 · 2025: 3 · 2024: 3
FWCI
1.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R01CA257971)
Topics
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Keywords
cancer incidence, environmental exposure, young adults, ambient air pollution, ozone, PM2.5, prostate cancer, female breast cancer, melanoma, smoking, physical inactivity, socioeconomic factors, lifestyle factors, New York State
MeSH terms
Aged, Air Pollutants, Air Pollution, Breast Neoplasms, Environmental Exposure, Humans, Male, Melanoma, New York, Prostatic Neoplasms, Incidence, Particulate Matter, Young Adult

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