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Cited by 23Ovarian function and disordersReproductive Health and TechnologiesObesity, Physical Activity, Diet

Association between visceral adiposity index and infertility in reproductive-aged women in the United States

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Zhuang, Jiaru, Wang, Yuan, Wang, Shan, Hu, Renjing, Wu, Yibo·2024·Scientific Reports
DOI 10.1038/s41598-024-64849-0PMC PMC11189895
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Abstract

Over the years, obesity has become more commonplace and has had a substantial impact on several medical specialties, including reproductive medicine. The potential correlation between the visceral adiposity index (VAI) and infertility has yet to be determined. Women between the ages of 18 and 45 were included in this cross-sectional study, which was conducted as part of the National Health and Nutrition Examination Survey (NHANES) between 2015 and 2020. Three tertiles were used to group VAI levels. Subgroup analysis and weighted binary logistic regression were employed to investigate the independent relationship between VAI and infertility. Smooth curve fitting was used to explore nonlinear relationships. This cross-sectional study followed the criteria of the STROBE guidelines. Of the 1231 participants, 127 were infertile women aged 18–45 years. A higher VAI was associated with a higher prevalence of infertility (OR = 1.22, 95% CI:1.03–1.45), which remained consistent across all subgroups (p > 0.05 for all interactions). We demonstrated a positive nonlinear association between VAI and infertility using a smooth curve fit. A higher visceral adiposity index level is positively correlated with a higher incidence of infertility among women in the United States. Women who are infertile can be identified using the visceral obesity index, and controlling visceral obesity may help lower the chances of becoming infertile.

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  • The inclusion of height in the BRI formula distinguishes it from other obesity indices such as WWI or VAI, allowing it to more thoroughly reflect body composition and fat distribution.

    “Additionally, the inclusion of height in the BRI formula distinguishes it from other obesity indices such as WWI or VAI, allowing it to more thoroughly reflect an individual’s body composition and fat distribution14,20,21.”

    From The nonlinear association between body roundness index and infertility in married women (2025) · cites this paper as [14]

    The Calculation of VAI section gives a VAI formula with no separate height term, providing limited support for the comparison. The paper does not discuss BRI or WWI, establish that BRI includes height, or show that BRI reflects body composition and fat distribution more thoroughly than VAI. Page numbers are unavailable in our copy. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

  • The Visceral Adiposity Index (VAI) is positively correlated with increased infertility incidence.

    “Similarly, the Visceral Adiposity Index (VAI), which reflects dysfunction and accumulation of visceral adipose tissue, has been positively correlated with increased infertility incidence14.”

    From The nonlinear association between body roundness index and infertility in married women (2025) · cites this paper as [14]

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Research works printed but not linked: 41

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Cited by

Sorted by citations

Authors
Zhuang, J., Wang, Y., Wang, S., Hu, R., & Wu, Y.
Affiliations
  • Jiangnan University (CN)
  • Wuxi Fourth People's Hospital (CN)
Corresponding author
  • Hu, Renjing
  • Wu, Yibo
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2024-06-20
Volume
14
Issue
1
Pages
14230-14230
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-024-64849-0
PMC
PMC11189895
OpenAlex
W4399858360
Cited by
23
References
3
Citations by year
2026: 6 · 2025: 12 · 2024: 5
FWCI
9.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Wuxi Taihu Lake Talent Plan (4532001THMD)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
visceral adiposity index, infertility, women of reproductive age, visceral obesity, obesity, nonlinear relationship, NHANES
MeSH terms
Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Infertility, Female, Middle Aged, Nutrition Surveys, United States, Body Mass Index, Prevalence, Intra-Abdominal Fat, Adiposity, Young Adult, Obesity, Abdominal

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