Genetic analyses reveal association between rosacea and cardiovascular diseases
Open accessAbstract
Previous studies have shown that patients with rosacea tend to have a higher risk of developing cardiovascular diseases (CVDs). However, the potential causal relationship between genetic susceptibility to rosacea and the risk of CVDs remains unclear. Based on summary statistics from publicly available genome-wide association studies (GWASs), we detected the genetic association between rosacea and CVDs by a bidirectional two-sample Mendelian randomization (MR) analysis. The inverse-variance weighted (IVW) method was used as the primary analysis, while weighted median (WM) and MR-Egger were applied as complementary methods. For sensitivity analyses, we applied Cochran's Q test, the intercept of MR-Egger, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), funnel plot, and leave-one-out analysis. The MR analysis revealed that rosacea was associated with an elevated risk of hypertension (HTN) (OR = 1.0032, 95% CI [1.0001-1.0063], P = 0.04). However, no casual relationship was found between rosacea and risk of atrial fibrillation (AF) (OR = 1.0099, 95% CI [0.9823-1.0382], P = 0.49), coronary artery disease (CAD) (OR = 1.0138, 95% CI [0.9824-1.0462], P = 0.39), heart failure (HF) (OR = 0.9965, 95% CI [0.9671-1.0268], P = 0.82), ischemic stroke (IS) (OR = 0.9933, 95% CI [0.9545-1.0337], P = 0.74), or myocardial infarction (MI) (OR = 1.0001, 95% CI [0.9988-1.0013], P = 0.92). In the sensitivity analysis, significant heterogeneity was revealed in the MI subgroup according to the Cochran's Q test. Other sensitivity analyses indicated the stability of our results. Reverse MR analysis showed no significant genetic effect of cardiovascular disease on rosacea risk. We are the first to use MR analysis to explore the casual relationship between rosacea and the risk of various CVDs, revealing an increased risk of HTN in patients with rosacea.
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Bidirectional 2-sample Mendelian randomization analysis found a potential causal link between rosacea and cardiovascular disease.
“From genetics data, Gao et al (2025) utilized bidirectional 2-sample Mendelian randomization analysis, finding a potential causal link between rosacea and cardiovascular disease”
From Artificial intelligence–enabled precision medicine for inflammatory skin diseases (2026) · cites this paper as Gao et al, 2025
The Methods (Study design; page unavailable) confirm that Gao et al. used bidirectional two-sample Mendelian randomization. The Conclusion (page unavailable) describes a potential causal relationship specifically between rosacea and increased hypertension risk; the Discussion reports no statistically significant association for the other cardiovascular outcomes studied. The claim is therefore broader than the finding. (LLM, conf=0.88)
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- Authors
- Gao, Y., Xu, C., & Yan, Q.
- Affiliations
- Zhejiang Provincial People's Hospital (CN)
- Corresponding author
- Yan, Qiqi
- ORCID
- Xu, Chengan
- Venue
- Scientific Reports
- Published
- 2025-02-24
- Volume
- 15
- Issue
- 1
- Pages
- 6657-6657
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC11850808
- OpenAlex
- W4407870576
- Cited by
- 4
- References
- 37
- Citations by year
- 2026: 3 · 2025: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- rosacea, cardiovascular disease, hypertension, atrial fibrillation, coronary artery disease, heart failure, ischemic stroke, myocardial infarction, genetic susceptibility, bidirectional Mendelian randomization, causal inference, pleiotropy, heterogeneity, reverse causality, cardiovascular risk prediction models, cardiovascular risk stratification
- MeSH terms
- Atrial Fibrillation, Cardiovascular Diseases, Humans, Hypertension, Risk Factors, Rosacea, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Mendelian Randomization Analysis
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