Cellular proteostasis decline in human senescence
Open accessAbstract
A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.
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Cellular proteostasis decline in human senescence
Sabath, N., Levy‐Adam, F., Younis, A., Rozales, K., Meller, A., Hadar, S., Soueid‐Baumgarten, S., & Shalgi, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018138117 · Cited by 148 · see citing works
Cellular proteostasis decline in human senescence
(2019) · doi:10.1101/860775 · Cited by 5 · see citing works
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Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94 · see citing works
- Authors
- Montague-Cardoso, K.
- Corresponding author
- Montague-Cardoso, Karli
- Venue
- Communications Biology
- Published
- 2021-01-04
- Volume
- 4
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2399-3642 (ISSN-L)
- PMC
- PMC7782732
- OpenAlex
- W3119922891
- Cited by
- 6
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- cellular senescence, proteostasis, aging, human cells, senescent cells
- MeSH terms
- Proteostasis, Cells, Cultured, Humans, Cellular Senescence
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