The DOI matches its Crossref record; 456 of the 456 references it cites were found in a registry or an index.
NAD+ homeostasis in health and disease
Open accessAbstract
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave of scientific interest in NAD+. NAD+ levels decline during ageing, and alterations in NAD+ homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research.
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“Pharmacological agents that induce mitophagy and have a positive impact on murine healthspan include NAD + precursors (such as nicotinamide, nicotinamide mononucleotide and nicotinamide riboside) 124 and urolithin A 125 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [124]
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In the citing paper
“Accordingly, NAD+ homeostasis is required for the proper function of various metabolic tissues, including fat, muscle, intestines, kidneys and liver (reviewed in72).”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [72]
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Cites
1 retracted
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Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science · doi:10.1126/science.abe9985 · Cited by 439
Metadata
- Authors
- Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Thermo Fisher Scientific (Switzerland) (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Nature Metabolism
- Published
- 2020-01-20
- Volume
- 2
- Issue
- 1
- Pages
- 9-31
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W3000157665
- Cited by
- 627
- References
- 456
- Citations by year
- 2026: 102 · 2025: 101 · 2024: 92 · 2023: 110 · 2022: 110 · 2021: 77 · 2020: 34
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Aging (R01AG043930)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- NAD+ homeostasis, NAD+ metabolism, sirtuins, aging, age-related diseases, neurodegeneration, diabetes mellitus, cancer, healthspan, lifespan
- MeSH terms
- Animals, Disease, Glycolysis, Homeostasis, Humans, Longevity, Metabolism, NAD, NADP, Oxidation-Reduction, Phosphorylation, Subcellular Fractions, Sirtuins
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