Cited by 7,698Genomics and Phylogenetic StudiesBioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

UniProt: a worldwide hub of protein knowledge

Open access
The UniProt Consortium·2019·Nucleic Acids Research

Abstract

The UniProt Knowledgebase is a collection of sequences and annotations for over 120 million proteins across all branches of life. Detailed annotations extracted from the literature by expert curators have been collected for over half a million of these proteins. These annotations are supplemented by annotations provided by rule based automated systems, and those imported from other resources. In this article we describe significant updates that we have made over the last 2 years to the resource. We have greatly expanded the number of Reference Proteomes that we provide and in particular we have focussed on improving the number of viral Reference Proteomes. The UniProt website has been augmented with new data visualizations for the subcellular localization of proteins as well as their structure and interactions. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/nar/gky1049

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The newly added data includes mouse and rat proteins from UniProt, with their associated phenotype data extracted from the International Mouse Phenotyping Consortium and the Rat Genome Database.

    “The newly added data includes mouse and rat proteins from UniProt (5), with their associated phenotype data extracted from the International Mouse Phenotyping Consortium (6) and the Rat Genome Database (7), respectively.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
The UniProt Consortium
Affiliations
SIB Swiss Institute of Bioinformatics (CH)
Corresponding author
The UniProt Consortium
Venue
Nucleic Acids Research
Published
2018-11-05
Volume
47
Issue
D1
Pages
D506-D515
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W3136918052
Cited by
7,698
References
33
Citations by year
2026: 358 · 2025: 676 · 2024: 807 · 2023: 831 · 2022: 1111 · 2021: 1825 · 2020: 1620 · 2019: 449 · 2018: 5 · 2017: 1 · 2014: 1 · 2012: 1
FWCI
351.94
Type
journal article
Language
en
Open access
Locations
  • Nucleic Acids Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (U24HG007822)
  • National Human Genome Research Institute (U41HG007822, U41HG002273)
  • National Institute of General Medical Sciences (R01GM080646, P20GM103446, U01GM120953)
  • Biotechnology and Biological Sciences Research Council (BB/M011674/1)
  • British Heart Foundation (RG/13/5/30112)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
Keywords
protein sequence databases, protein annotation, reference proteomes, viral proteome, subcellular localization, protein structure, protein-protein interaction, data visualization, expert curation, rule-based annotation
MeSH terms
Sequence Analysis, Protein, Proteome, Databases, Protein, Knowledge Bases, Molecular Sequence Annotation, Data Curation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review