The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Healthy aging and the blood–brain barrier
Open accessAbstract
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communication between the CNS and peripheral tissues. The cells forming the BBB communicate with cells of the brain and in the periphery. This highly regulated interface changes with healthy aging. Here, we review those changes, starting with morphology and disruption. Transporter changes include those for amyloid beta peptide, glucose and drugs. Brain fluid dynamics, pericyte health and basement membrane and glycocalyx compositions are all altered with healthy aging. Carrying the ApoE4 allele leads to an acceleration of most of the BBB’s age-related changes. We discuss how alterations in the BBB that occur with healthy aging reflect adaptation to the postreproductive phase of life and may affect vulnerability to age-associated diseases. The authors review how the blood–brain barrier, a regulatory interface that controls interactions between the blood and central nervous system, changes during healthy aging, and discuss how some of these changes may predispose to age-associated diseases.
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“This topic has been recently reviewed extensively elsewhere [53].”
BackgroundAburto, M. R., & Cryan, J. F. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00890-0 · Cited by 359
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Astrocyte Endfeet in Brain Function and Pathology: Open Questions
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Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies
Alkhalifa, A. E., Al-Ghraiybah, N. F., Odum, J., Shunnarah, J. G., Austin, N., & Kaddoumi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216288 · Cited by 212
Metadata
- Authors
- Banks, W. A., Reed, M. J., Logsdon, A. F., Rhea, E. M., & Erickson, M. A.
- Venue
- Nature Aging
- Published
- 2021-03-15
- Volume
- 1
- Issue
- 3
- Pages
- 243-254
- ISSN
- 2662-8465 (ISSN-L)
- OpenAlex
- W3137606405
- Cited by
- 292
- References
- 160
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- green
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