Intravenous Fluids and Acute Kidney Injury

Ding, Xiaoqiang; Cheng, Zhen; Qian, Qi

doi:10.1159/000452702

Cited by 6,827

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Intravenous Fluids and Acute Kidney Injury

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Ding, Xiaoqiang, Cheng, Zhen, Qian, Qi·2017·Blood Purification

DOI 10.1159/000452702

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Abstract

Over 50% of the human body is comprised of fluids that are distributed in defined compartments. Although compartmentalized, these fluids are dynamically connected. Fluids, electrolytes, and acid-base balance in each compartment are tightly regulated, mostly in an energy-dependent manner to achieve their designed functions. For over a century, our understanding of the microvascular fluid homeostasis has evolved from hypothesized Ernest Starling principle to evidence-based and the revised Starling principle, incorporating the functional endothelial surface layer. The kidney is a highly vascular and encapsulated organ that is exquisitely sensitive to inadequate (insufficient or excess) blood flow. The kidney is particularly sensitive to venous congestion, and studies show that reduced venous return triggers a greater degree of kidney damage than that from lacking arterial flow. Thus, fluid overload can induce severe and sustained kidney injury. In the setting of established acute kidney injury, fluid management can be challenging. Impaired capacity of urine output and urine concentration and dilution should be taken into consideration when designing fluid therapy. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=452702.

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Authors: Ding, X., Cheng, Z., & Qian, Q.
Venue: Blood Purification
Publisher: S. Karger AG
Published: 2017
Volume: 43
Issue: 1-3
Pages: 163-172
ISSN: 0253-5068 (ISSN-L)
1421-9735
DOI: 10.1159/000452702
OpenAlex: W2581605534
Cited by: 6,827
References: 7
FWCI: 420.98
Type: journal article
Language: en
Open access: bronze
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)

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Intravenous Fluids and Acute Kidney Injury

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