The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Integrins: roles in cancer development and as treatment targets
Open accessAbstract
The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (alpha5beta1, alphavbeta3 and alphavbeta5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases.
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Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Cited by
Integrins in angiogenesis and lymphangiogenesis
Avraamides, C. J., Garmy-Susini, B., & Varner, J. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2353 · Cited by 1,050
Self-citationExploring the Role of RGD-Recognizing Integrins in Cancer
Nieberler, M., Reuning, U., Reichart, F., Notni, J., Wester, H.-J., Schwaiger, M., Weinmüller, M., Räder, A., Steiger, K., & Kessler, H. (2017) · Cancers · doi:10.3390/cancers9090116 · Cited by 429
Liu, S. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900167c · Cited by 344
Cell–matrix adhesion in vascular development
HYNES, R. O. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02569.x · Cited by 261
Integrins as receptor targets for neurological disorders
Wu, X., & Reddy, D. S. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.008 · Cited by 175
“…pharmacological targets for designing new therapies for brain diseases (Horwitz, 1997; Clemetson & Clemetson, 1998; Wu & Davis, 1998; Davis et al., 2001; Ross & Borg, 2001; Gall & Lynch, 2004; Jin & Varner, 2004; Lal et al., 2007; Cox et al., 2010; Millard et al., 2011; Reichardt & Prokop, 2011).”
Metadata
- Authors
- Jin, H., & Varner, J.
- Venue
- British Journal of Cancer
- Published
- 2004-02
- Volume
- 90
- Issue
- 3
- Pages
- 561-565
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2088056286
- Cited by
- 574
- References
- 3
- FWCI
- 22.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
