Integrins in angiogenesis and lymphangiogenesis
Open accessAbstract
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration and survival during angiogenesis and lymphangiogenesis, whereas other integrins promote pro-angiogenic macrophage trafficking to tumours. Several integrin-targeted therapeutic agents are currently in clinical trials for cancer therapy. Here, we review the evidence implicating integrins as a family of fundamental regulators of angiogenesis and lymphangiogenesis.
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α4β1/αvβ3 integrins are expressed in hematopoietic and endothelial cells and play a key role in inflammation.
“The α4β1/αvβ3 integrins are expressed in hematopoietic and endothelial cells [14] and play a key role in inflammation [15], [29], [46], [47].”
From Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo (2014) · cites this paper as [14]
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- Authors
- Avraamides, C. J., Garmy-Susini, B., & Varner, J. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Varner, Judith A.
- Venue
- Nature Reviews Cancer
- Published
- 2008-05-22
- Volume
- 8
- Issue
- 8
- Pages
- 604-617
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC2577722
- OpenAlex
- W2072889522
- Cited by
- 1,050
- References
- 4
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 26 · 2023: 42 · 2022: 60 · 2021: 78 · 2020: 62 · 2019: 66 · 2018: 47 · 2017: 61 · 2016: 67 · 2015: 49 · 2014: 63 · 2013: 70 · 2012: 77
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- California Breast Cancer Research Program
- National Institutes of Health
- National Cancer Institute (R01CA126820, R01CA083133)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- integrins, angiogenesis, lymphangiogenesis, tumor growth, tumour metastasis, endothelial cell migration, macrophage trafficking, extracellular matrix, integrin-targeted therapy, cancer therapy
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Integrins, Angiogenesis Inhibitors, Lymphangiogenesis
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