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Cited by 165Palliative Care and End-of-Life IssuesPalliative and Oncologic CarePain Management and Opioid Use

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis

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Uronis, H E, Currow, D C, McCrory, D C, Samsa, G P, Abernethy, A P·2008·British Journal of Cancer
DOI 10.1038/sj.bjc.6604161PMC PMC2361446
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Abstract

The aim of this study was to determine the efficacy of palliative oxygen for relief of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled trials, comparing oxygen and medical air in cancer patients not qualifying for home oxygen therapy. Abstracts were reviewed and studies were selected using Cochrane methodology. The included studies provided oxygen at rest or during a 6-min walk. The primary outcome was dyspnoea. Standardised mean differences (SMDs) were used to combine scores. Five studies were identified; one was excluded from meta-analysis due to data presentation. Individual patient data were obtained from the authors of the three of the four remaining studies (one each from England, Australia, and the United States). A total of 134 patients were included in the meta-analysis. Oxygen failed to improve dyspnoea in mildly- or non-hypoxaemic cancer patients (SMD=-0.09, 95% confidence interval -0.22 to 0.04; P=0.16). Results were stable to a sensitivity analysis, excluding studies requiring the use of imputed quantities. In this small meta-analysis, oxygen did not provide symptomatic benefit for cancer patients with refractory dyspnoea, who would not normally qualify for home oxygen therapy. Further study of the use of oxygen in this population is warranted given its widespread use.

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Crossref · 10.1038/sj.bjc.6604161

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Figure 1 Flowchart of articles reviewed for the systematic analysis of the benefit of palliative oxygen for the relief of dyspnoea in people with cancer who do not qualify for long-term domiciliary oxygen therapy.
Figure 1 Flowchart of articles reviewed for the systematic analysis of the benefit of palliative oxygen for the relief of dyspnoea in people with cancer who do not qualify for long-term domiciliary oxygen therapy.CC BY · PubMed Central
Figure 2 Estimation of efficacy of oxygen in the treatment of dyspnoea in cancer patients who do not qualify for long-term domiciliary oxygen therapy.
Figure 2 Estimation of efficacy of oxygen in the treatment of dyspnoea in cancer patients who do not qualify for long-term domiciliary oxygen therapy.CC BY · PubMed Central
Figure 3 Sensitivity analysis of blinded, randomised controlled trials exploring the symptomatic benefit of oxygen therapy in reducing refractory dyspnoea in a palliative population which does not qualify for domiciliary oxygen – no studies requiring use of imputed quantities.
Figure 3 Sensitivity analysis of blinded, randomised controlled trials exploring the symptomatic benefit of oxygen therapy in reducing refractory dyspnoea in a palliative population which does not qualify for domiciliary oxygen – no studies requiring use of imputed quantities.CC BY · PubMed Central

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  1. Storey P, Knight CF (2003) UNIPAC Four: Management of Selected Non-Pain Symptoms in the Terminally Ill, Vol. 83 Glenview, IL: American Academy of Hospice and Palliative Medicine

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Metadata

Authors
Uronis, H. E., Currow, D. C., McCrory, D. C., Samsa, G. P., & Abernethy, A. P.
Affiliations
  • Duke Medical Center (US)
  • Flinders University (AU)
  • Duke University (US)
Corresponding author
Abernethy, A P
ORCID
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2008-01
Volume
98
Issue
2
Pages
294-299
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/sj.bjc.6604161
PMC
PMC2361446
OpenAlex
W2070591275
Cited by
165
References
40
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 19 · 2014: 13 · 2013: 12 · 2012: 18
FWCI
1.65
Type
journal article
Language
en
Open access
Licence
Locations
  • British Journal of Cancer (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Flinders Academic Commons (Flinders University) (submittedVersion)
  • DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
Funders
Agency for Healthcare Research and Quality (T32HS000079)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
dyspnea, cancer, medical air, home oxygen therapy, symptom relief, 6-minute walk test
MeSH terms
Aged, Algorithms, Hypoxia, Dyspnea, Female, Humans, Male, Neoplasms, Oxygen, Oxygen Inhalation Therapy, Palliative Care, Randomized Controlled Trials as Topic, Treatment Outcome

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