The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
Open accessAbstract
The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype in cancer appears to be the common denominator of diverse molecular abnormalities in cancer and may be associated with a (potentially reversible) suppression of mitochondrial function. The generic drug dichloroacetate is an orally available small molecule that, by inhibiting the pyruvate dehydrogenase kinase, increases the flux of pyruvate into the mitochondria, promoting glucose oxidation over glycolysis. This reverses the suppressed mitochondrial apoptosis in cancer and results in suppression of tumour growth in vitro and in vivo. Here, we review the scientific and clinical rationale supporting the rapid translation of this promising metabolic modulator in early-phase cancer clinical trials.
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Cites
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Cited by
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Metadata
- Authors
- Michelakis, E. D., Webster, L., & Mackey, J. R.
- Venue
- British Journal of Cancer
- Published
- 2008-09-02
- Volume
- 99
- Issue
- 7
- Pages
- 989-994
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2018971639
- Cited by
- 656
- References
- 33
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Michelakis, E. D., Webster, L., & Mackey, J. R. (2008). Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6604554
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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