The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases
Open accessAbstract
BACKGROUND: Synchronous metastases of colorectal cancer (CRC) are considered to be of worse prognostic value compared with metachronous metastases, but only few and conflicting data have been reported on this issue. METHODS: We retrospectively investigated patient demographics, primary tumour characteristics and overall survival (OS) in 550 advanced CRC patients with metachronous vs synchronous metastases, who participated in the phase III CAIRO study. For this purpose only patients with a prior resection of the primary tumour were considered. RESULTS: The clinical and pathological characteristics associated with poor prognosis that we observed more often in patients with synchronous metastases (n=280) concerned an abnormal serum lactate dehydrogenase (LDH) concentration (P=0.01), a worse WHO performance status (P=0.02), primary tumour localisation in the colon (P=0.002) and a higher T stage (P=0.0006). No significant difference in median OS was observed between patients with synchronous metastases and metachronous metastases (17.6 vs 18.5 months, respectively, P=0.24). CONCLUSION: Despite unfavourable clinicopathological features in patients with synchronous metastases with a resected primary tumour compared to patients with metachronous metastases, no difference in the median OS was observed. Possible explanations include a (partial) chemoresistance in patients with metachronous disease because of previous adjuvant treatment, whereas differences between the two groups in screening procedures resulting in a lead time bias to diagnosis or in prognostic molecular markers remain speculative.
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Tournigand, C., André, T., Achille, E., Lledo, G., Flesh, M., Mery-Mignard, D., Quinaux, E., Couteau, C., Buyse, M., Ganem, G., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.113 · Cited by 2,915 · cited 1×
“Consequently, few data are available on the prognostic value of this parameter with conflicting results (Nordic Gastrointestinal Tumor Adjuvant Therapy Group, 1992; Graf et al, 1994; Freyer et al, 2000; Saltz et al, 2000; Tournigand et al, 2004; Colucci et al, 2005).”
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Cited by
Adam, R., de Gramont, A., Figueras, J., Kokudo, N., Kunstlinger, F., Loyer, E., Poston, G., Rougier, P., Rubbia-Brandt, L., Sobrero, A., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.06.006 · Cited by 607
Simkens, L. H. J., van Tinteren, H., May, A., ten Tije, A. J., Creemers, G.-J. M., Loosveld, O. J. L., de Jongh, F. E., Erdkamp, F. L. G., Erjavec, Z., van der Torren, A. M. E., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62004-3 · Cited by 517
Self-citationVogel, J. D., Felder, S. I., Bhama, A. R., Hawkins, A. T., Langenfeld, S. J., Shaffer, V. O., Thorsen, A. J., Weiser, M. R., Chang, G. J., Lightner, A. L., et al. (2022) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000002323 · Cited by 401
Interconnectivity between molecular subtypes and tumor stage in colorectal cancer
Coebergh van den Braak, R. R. J., ten Hoorn, S., Sieuwerts, A. M., Tuynman, J. B., Smid, M., Wilting, S. M., Martens, J. W. M., Punt, C. J. A., Foekens, J. A., Medema, J. P., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07316-z · Cited by 27
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Metadata
- Authors
- Mekenkamp, L. J. M., Koopman, M., Teerenstra, S., van Krieken, J. H. J. M., Mol, L., Nagtegaal, I. D., & Punt, C. J. A.
- Venue
- British Journal of Cancer
- Published
- 2010-06-15
- Volume
- 103
- Issue
- 2
- Pages
- 159-164
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2010760693
- Cited by
- 162
- References
- 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases. https://app.cochat.ai/papers/10.1038/sj.bjc.6605737
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- Mekenkamp, L. J. M., Koopman, M., Teerenstra, S., van Krieken, J. H. J. M., Mol, L., Nagtegaal, I. D., & Punt, C. J. A. (2010). Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6605737
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
