The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy
Open accessAbstract
Cyclo‐oxygenase is expressed in cells in two distinct isoforms. Cyclo‐oxygenase‐1 is present constitutively whilst cyclo‐oxygenase‐2 is expressed primarily after inflammatory insult. The activity of cyclo‐oxygenase‐1 and ‐2 results in the production of a variety of potent biological mediators (the prostaglandins) that regulate homeostatic and disease processes. Inhibitors of cyclo‐oxygenase include the nonsteroidal anti‐inflammatory drugs (NSAIDs) aspirin, ibuprofen and diclofenac. NSAIDs inhibit cyclo‐oxygenase‐2 at the site of inflammation, to produce their therapeutic benefits, as well as cyclo‐oxygenase‐1 in the gastric mucosa, which produces gastric damage. Most recently selective inhibitors of cyclo‐oxygenase‐2 have been developed and introduced to man for the treatment of arthritis. Moreover, recent epidemiological evidence suggests that cyclo‐oxygenase inhibitors may have important therapeutic relevance in the prevention of some cancers or even Alzheimer's disease. This review will discuss how the new advancements in NSAIDs research has led to the development of a new class of NSAIDs that has far reaching implications for the treatment of disease. British Journal of Pharmacology (1999) 128, 1121–1132; doi:10.1038/sj.bjp.0702897
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Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11693 · Cited by 1,659
Self-citationRisk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132
Yamamoto, K., Arakawa, T., Ueda, N., & Yamamoto, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31315 · Cited by 647 · cited 3×
“These pathways include, but are not limited to, reactive oxygen intermediates (Feng et al., 1995), NF-kB and NF-IL6 (Yamamoto et al., 1995), Ras/Rac1/ MEKK-1/JNK kinase/JNK signal transduction leading to phosphorylation of c-Jun (Xie & Herschman, 1996), ceramide (Hayakawa et al., 1996), mitogen-activated protein kinas…”
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Cited by
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448
Diclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats
Süleyman, H., Akçay, F., & Altinkaynak, K. (2002) · Pharmacological Research · doi:10.1006/phrs.2001.0933 · Cited by 55
Metadata
- Authors
- Mitchell, J. A., & Warner, T. D.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1999-11
- Volume
- 128
- Issue
- 6
- Pages
- 1121-1132
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1974450761
- Cited by
- 321
- References
- 3
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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