The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Antagonism of AT2 receptors augments Angiotensin II‐induced abdominal aortic aneurysms and atherosclerosis
Open accessAbstract
We have recently demonstrated that chronic infusion of Angiotensin II into apoE−/− mice promotes the development of abdominal aortic aneurysms. To determine the involvement of specific Angiotensin II receptors in this response, we co‐infused Angiotensin II (1000 ng kg−1 min−1 for 28 days) with losartan (30 mg kg−1 day−1) or PD123319 (3 mg kg−1 day−1) to antagonize AT1 and AT2 receptors, respectively. Infusion of Angiotensin II promoted the development of abdominal aortic aneurysms in 70% of mature female apoE−/− mice. The formation of aortic aneurysms was totally inhibited by co‐infusion of Angiotensin II with losartan (30 mg kg−1 day−1; P=0.003). In contrast, the co‐infusion of Angiotensin II with PD123319 resulted in a marked increase in the incidence and severity of aortic aneurysms. To determine whether AT2 antagonism also promoted Angiotensin II‐induced atherosclerosis, Angiotensin II was infused into young female apoE−/− mice that had little spontaneous atherosclerosis. In these mice, co‐infusion of PD123319 led to a dramatic increase in the extent of atherosclerosis. This increase was associated with no change in plasma lipid concentrations and only transient and modest increases in blood pressure during co‐infusion with PD123319. While antagonism of AT1 receptors totally prevented the formation of aneurysms, antagonism of AT2 receptors promoted a large increase in the severity of Angiotensin II‐induced vascular pathology. British Journal of Pharmacology (2001) 134, 865–870; doi:10.1038/sj.bjp.0704331
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1 retracted
Fujiyama, S., Matsubara, H., Nozawa, Y., Maruyama, K., Mori, Y., Tsutsumi, Y., Masaki, H., Uchiyama, Y., Koyama, Y., Nose, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.1.22 · Cited by 202
RetractedAngiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,853
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · cited 2×
“However, as expected by the age of the mice, (Nakashima et al., 1994) even the group infused with saline had extensive atherosclerotic lesions and, therefore, the relatively brief infusion of Angiotensin II for 28 days did not produce a measurable increase in atherosclerosis.”
BackgroundMethodAngiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice
Daugherty, A., Manning, M. W., & Cassis, L. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7818 · Cited by 1,368
Self-citationPyo, R., Lee, J. K., Shipley, J. M., Curci, J. A., Mao, D., Ziporin, S. J., Ennis, T. L., Shapiro, S. D., Senior, R. M., & Thompson, R. W. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8931 · Cited by 830
Nakajima, M., Hutchinson, H. G., Fujinaga, M., Hayashida, W., Morishita, R., Zhang, L., Horiuchi, M., Pratt, R. E., & Dzau, V. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10663 · Cited by 680
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaître, V., Tipping, P., Drew, A., Eeckhout, Y., Shapiro, S., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 661
Tangirala, R. K., Rubin, E. M., & Palinski, W. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39713-3 · Cited by 514
Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function
Carey, R. M., Wang, Z.-Q., & Siragy, H. M. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.155 · Cited by 431
Weiss, D., Kools, J. J., & Taylor, W. R. (2001) · Circulation · doi:10.1161/01.cir.103.3.448 · Cited by 368
Cited by
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Habashi, J. P., Judge, D. P., Holm, T. M., Cohn, R. D., Loeys, B. L., Cooper, T. K., Myers, L., Klein, E. C., Liu, G., Calvi, C., et al. (2006) · Science · doi:10.1126/science.1124287 · Cited by 1,794
Physiology of Local Renin-Angiotensin Systems
Paul, M., Poyan Mehr, A., & Kreutz, R. (2006) · Physiological Reviews · doi:10.1152/physrev.00036.2005 · Cited by 1,739
Wang, Y., Ait-Oufella, H., Herbin, O., Bonnin, P., Ramkhelawon, B., Taleb, S., Huang, J., Offenstadt, G., Combadière, C., Rénia, L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38136 · Cited by 414
NOX1 Deficiency Protects From Aortic Dissection in Response to Angiotensin II
Gavazzi, G., Deffert, C., Trocme, C., Schäppi, M., Herrmann, F. R., & Krause, K.-H. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.089706 · Cited by 135
Zhong, L., He, X., Si, X., Wang, H., Li, B., Hu, Y., Li, M., Chen, X., Liao, W., Liao, Y., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311917 · Cited by 104
Metadata
- Authors
- Daugherty, A., Manning, M. W., & Cassis, L. A.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 134
- Issue
- 4
- Pages
- 865-870
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2047942069
- Cited by
- 289
- References
- 23
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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