The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice
Open accessAbstract
Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men. Ang II-dependent TGF-beta activity promotes aortic aneurysm progression in experimental Marfan syndrome. However, the role of TGF-beta in experimental models of AAA has not been comprehensively assessed. Here, we show that systemic neutralization of TGF-beta activity breaks the resistance of normocholesterolemic C57BL/6 mice to Ang II-induced AAA formation and markedly increases their susceptibility to the disease. These aneurysms displayed a large spectrum of complications on echography, including fissuration, double channel formation, and rupture, leading to death from aneurysm complications. The disease was refractory to inhibition of IFN-gamma, IL-4, IL-6, or TNF-alpha signaling. Genetic deletion of T and B cells or inhibition of the CX3CR1 pathway resulted in partial protection. Interestingly, neutralization of TGF-beta activity enhanced monocyte invasiveness, and monocyte depletion markedly inhibited aneurysm progression and complications. Finally, TGF-beta neutralization increased MMP-12 activity, and MMP-12 deficiency prevented aneurysm rupture. These results clearly identify a critical role for TGF-beta in the taming of the innate immune response and the preservation of vessel integrity in C57BL/6 mice, which contrasts with its reported pathogenic role in Marfan syndrome.
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Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V, & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,866
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Habashi, J. P., Judge, D. P., Holm, T. M., Cohn, R. D., Loeys, B. L., Cooper, T. K., Myers, L., Klein, E. C., Liu, G., Calvi, C., et al. (2006) · Science · doi:10.1126/science.1124287 · Cited by 1,794
Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor
Loeys, B. L., Schwarze, U., Holm, T., Callewaert, B. L., Thomas, G. H., Pannu, H., De Backer, J. F., Oswald, G. L., Symoens, S., Manouvrier, S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055695 · Cited by 1,663
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Neptune, E. R., Frischmeyer, P. A., Arking, D. E., Myers, L., Bunton, T. E., Gayraud, B., Ramirez, F., Sakai, L. Y., & Dietz, H. C. (2003) · Nature Genetics · doi:10.1038/ng1116 · Cited by 1,404
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice
Daugherty, A., Manning, M. W., & Cassis, L. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7818 · Cited by 1,368
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
Longo, G. M., Xiong, W., Greiner, T. C., Zhao, Y., Fiotti, N., & Baxter, B. T. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215334 · Cited by 877
Pyo, R., Lee, J. K., Shipley, J. M., Curci, J. A., Mao, D., Ziporin, S. J., Ennis, T. L., Shapiro, S. D., Senior, R. M., & Thompson, R. W. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8931 · Cited by 830
Transforming growth factor-β in T-cell biology
Gorelik, L., & Flavell, R. A. (2002) · Nature Reviews Immunology · doi:10.1038/nri704 · Cited by 792
Combadière, C., Potteaux, S., Rodero, M., Simon, T., Pezard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 663
Self-citationInflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms
Shimizu, K., Mitchell, R. N., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000214999.12921.4f · Cited by 627
Cited by
Abdominal aortic aneurysm: update on pathogenesis and medical treatments
Golledge, J. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0114-9 · Cited by 788
Lessons on the pathogenesis of aneurysm from heritable conditions
Lindsay, M. E., & Dietz, H. C. (2011) · Nature · doi:10.1038/nature10145 · Cited by 473
Cellular Mechanisms of Aortic Aneurysm Formation
Quintana, R. A., & Taylor, W. R. (2019) · Circulation Research · doi:10.1161/circresaha.118.313187 · Cited by 435
Monocytes and macrophages in abdominal aortic aneurysm
Raffort, J., Lareyre, F., Clément, M., Hassen-Khodja, R., Chinetti, G., & Mallat, Z. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.52 · Cited by 432
Self-citationTGF-β Signaling in Control of Cardiovascular Function
Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360
Metadata
- Authors
- Wang, Y., Ait-Oufella, H., Herbin, O., Bonnin, P., Ramkhelawon, B., Taleb, S., Huang, J., Offenstadt, G., Combadière, C., Rénia, L., Johnson, J. L., Tharaux, P.-L., Tedgui, A., & Mallat, Z.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-02-01
- Volume
- 120
- Issue
- 2
- Pages
- 422-432
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2109329928
- Cited by
- 414
- References
- 54
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice. https://app.cochat.ai/papers/10.1172/jci38136
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- Wang, Y., Ait-Oufella, H., Herbin, O., Bonnin, P., Ramkhelawon, B., Taleb, S., Huang, J., Offenstadt, G., Combadière, C., Rénia, L., Johnson, J. L., Tharaux, P.-L., Tedgui, A., & Mallat, Z. (2010). TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci38136
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
