Histamine receptors that influence blockage of the normal human nasal airway
Open accessAbstract
The aim of this study was to investigate the mechanisms by which histamine causes nasal blockage. Histamine, 40–800 μ g, intranasally into each nostril, induced significant blockage of the nasal airway in normal human subjects, as measured by acoustic rhinometry. Oral pretreatment with cetirizine, 5–30 mg, the H 1 antagonist, failed to reverse completely the nasal blockage induced by histamine, 400 μ g. Dimaprit, 50–200 μ g, the H 2 agonist, intranasally, caused nasal blockage, which was reversed by oral pretreatment with ranitidine, 75 mg, the H 2 antagonist. A combination of cetirizine, 20 mg, and ranitidine, 75 mg, caused greater inhibition of the nasal blockage caused by histamine, 400 μ g, than cetirizine alone. In the presence of both antagonists, there was residual histamine‐induced nasal blockage. R‐α‐methylhistamine (R‐α‐MeH), 100–600 μ g, the H 3 agonist, intranasally, caused nasal blockage, which was not inhibited by either cetirizine or ranitidine. Thioperamide, 700 μ g, the H 3 antagonist, intranasally, reversed the R‐α‐MeH‐induced nasal blockage. Thioperamide alone had no significant action on the nasal blockage induced by histamine, 400 and 1000 μ g, but, in the presence of cetirizine, 20 mg, thioperamide further reduced the histamine‐induced nasal blockage. Corynanthine, 2 mg, the α1‐adrenoceptor antagonist, administered intranasally, caused nasal blockage. Corynanthine produced a greater increase in nasal blockage when in combination with bradykinin compared to its combination with R‐α‐MeH. There appears to be a contribution of H 1, H 2 and H 3 receptors to histamine‐induced nasal blockage in normal human subjects. The sympathetic nervous system actively maintains nasal patency and we suggest that activation of nasal H 3 receptors may downregulate sympathetic activity. British Journal of Pharmacology (2005) 144, 867–874. doi:10.1038/sj.bjp.0706118
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The objective findings of improved nasal airway resistance suggest that the H2 histamine receptor modulates nasal tissue response to histamine.
“The objective findings of improved nasal airway resistance suggest that the H2 histamine receptor does modulate nasal tissue response to histamine.1193-1195”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1194]
The Results and Discussion report that ranitidine reduced histamine-induced nasal blockage in one experiment, supporting a possible H2 role, but its effects were variable across experiments. The Measurement of nasal patency section says the objective measure was minimum nasal cross-sectional area by acoustic rhinometry, not nasal airway resistance. (LLM, conf=0.86)
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
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- Authors
- Taylor‐Clark, T., Sodha, R., Warner, B., & Foreman, J.
- Affiliations
- University College London (GB)
- Corresponding author
- Foreman, John
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2005-03
- Volume
- 144
- Issue
- 6
- Pages
- 867-874
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1576069
- OpenAlex
- W2070207130
- Cited by
- 44
- References
- 35
- Citations by year
- 2025: 1 · 2023: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- histamine receptors, nasal obstruction, histamine H1 receptor, histamine H2 receptor, histamine H3 receptor, alpha1-adrenoceptors, nasal patency, sympathetic nervous system, cetirizine, ranitidine, thioperamide, corynanthine, bradykinin, alpha-methylhistamine, acoustic rhinometry
- MeSH terms
- Adult, Dose-Response Relationship, Drug, Drug Interactions, Histamine, Histamine Antagonists, Humans, Methylhistamines, Middle Aged, Nasal Cavity, Ranitidine, Receptors, Histamine, Time Factors, Nasal Obstruction, Cetirizine, Histamine Agonists
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