The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
75 years of opioid research: the exciting but vain quest for the Holy Grail
Open accessAbstract
Over the 75‐year lifetime of the British Pharmacological Society there has been an enormous expansion in our understanding of how opioid drugs act on the nervous system, with much of this effort aimed at developing powerful analgesic drugs devoid of the side effects associated with morphine – the Holy Grail of opioid research. At the molecular and cellular level multiple opioid receptors have been cloned and characterised, their potential for oligomerisation determined, a large family of endogenous opioid agonists has been discovered, multiple second messengers identified and our understanding of the adaptive changes to prolonged exposure to opioid drugs (tolerance and physical dependence) enhanced. In addition, we now have greater understanding of the processes by which opioids produce the euphoria that gives rise to the intense craving for these drugs in opioid addicts. In this article, we review the historical pathway of opioid research that has led to our current state of knowledge. British Journal of Pharmacology(2006)147, S153–S162. doi:10.1038/sj.bjp.0706435
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Cites
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Cited by
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
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Self-citationThe effects of opioids and opioid analogs on animal and human endocrine systems
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The role of the opioid system in decision making and cognitive control: a review
van Steenbergen, H., Eikemo, M., & Leknes, S. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-019-00710-6 · Cited by 118
Impact of the opioid system on the reproductive axis
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Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106
Metadata
- Authors
- Corbett, A. D., Henderson, G., McKnight, A. T., & Paterson, S. J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 147
- Issue
- S1
- Pages
- S153-62
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1655590724
- Cited by
- 358
- References
- 34
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
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