Cited by 106Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeural and Behavioral Psychology Studies

Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing

Coccurello, Roberto·2019·Behavioural Brain Research

Abstract

Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.

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Crossref · 10.1016/j.bbr.2019.112041

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211 of 211 references verified0 citation errors · 0 not checkable

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  • Many individuals with ASD or depression without co-occurring EDs exhibit atypical eating behaviours that do not necessarily stem from weight and shape concerns or difficulties processing hunger or satiety.

    “many individuals with ASD or depression without co-occurring EDs still exhibit atypical eating behaviours that do not necessarily stem from weight and shape concerns or difficulties processing hunger or satiety”

    From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Coccurello, 2019

  • Impaired reward processing is associated with such symptoms across different psychiatric disorders.

    “This is in line with previous literature suggesting that impaired reward processing is associated with such symptoms across different psychiatric disorders.56,61,121–125”

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Authors
Coccurello, R.
Affiliations
Institute for Complex Systems (IT)
Corresponding author
Coccurello, Roberto
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2019-10
Volume
372
Pages
112041
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2949303212
Cited by
106
References
212
Citations by year
2026: 13 · 2025: 24 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 5 · 2019: 2
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministero della Salute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
anhedonia, depression, reward processing, lateral hypothalamus, ventral pallidum, lateral habenula, nucleus accumbens, ventral tegmental area, dopamine, orexin, GABAergic neurotransmission, endocannabinoid signaling
MeSH terms
Orexins, Animals, Appetite, Depression, Depressive Disorder, Dopamine, Humans, Hypothalamus, Neural Pathways, Synaptic Transmission, Nucleus Accumbens, Reward, Ventral Tegmental Area, Habenula, GABAergic Neurons, Anhedonia, Endocannabinoids

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