Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Abstract
Anhedonia is an elusive symptom in depression symptomatology. The present review frames the notion of anhedonia as reduced ability to experience pleasure and diminished sensitivity to rewarding stimuli such as palatable food or social interaction within the context of appetite dysregulation in depression, addressing the main neural networks involved in the alteration of brain reward processing. This circuit-based framework focuses on selected brain regions such as lateral hypothalamus, ventral pallidum, lateral habenula and mesocorticolimbic target areas such as nucleus accumbens and ventral tegmental area. The examination in particular of the role of dopamine, orexin and GABAergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms.
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Many individuals with ASD or depression without co-occurring EDs exhibit atypical eating behaviours that do not necessarily stem from weight and shape concerns or difficulties processing hunger or satiety.
“many individuals with ASD or depression without co-occurring EDs still exhibit atypical eating behaviours that do not necessarily stem from weight and shape concerns or difficulties processing hunger or satiety”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Coccurello, 2019
Impaired reward processing is associated with such symptoms across different psychiatric disorders.
“This is in line with previous literature suggesting that impaired reward processing is associated with such symptoms across different psychiatric disorders.56,61,121–125”
From Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making (2024) · cites this paper as [121]
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Coletânea Ludovicense de Psicologia - Volume 5
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The hidden burden of narcolepsy: anxiety and depression among patients
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Gut–Brain Axis in Mental Diseases
Kar, E., & Kar, F. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_5
Shang, Z., & Sun, X. (2025) · Child Psychiatry & Human Development · doi:10.1007/s10578-025-01917-0
The role of endocannabinoids in nonpharmacological addiction
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Schulz, C., Peglow, F., la Fougère, C., Bender, B., Klaus, J., Ellinger, S., Walter, M., Reischl, G., Reimold, M., & Kroemer, N. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.04.691596
NAcLat-DBS reduces GABAB1R expression of dopamine neurons to correct depressive symptoms in CMS micePreprint
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- Authors
- Coccurello, R.
- Affiliations
- Institute for Complex Systems (IT)
- Corresponding author
- Coccurello, Roberto
- ORCID
- Coccurello, Roberto
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 372
- Pages
- 112041
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2949303212
- Cited by
- 106
- References
- 212
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 5 · 2019: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero della Salute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anhedonia, depression, reward processing, lateral hypothalamus, ventral pallidum, lateral habenula, nucleus accumbens, ventral tegmental area, dopamine, orexin, GABAergic neurotransmission, endocannabinoid signaling
- MeSH terms
- Orexins, Animals, Appetite, Depression, Depressive Disorder, Dopamine, Humans, Hypothalamus, Neural Pathways, Synaptic Transmission, Nucleus Accumbens, Reward, Ventral Tegmental Area, Habenula, GABAergic Neurons, Anhedonia, Endocannabinoids
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