Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

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Items 101–173 of 173

1. Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)
   Amy Timmons, Mark J. Seierstad, Richard L. Apodaca, Matt Epperson, Dan Pippel, Sean M. Brown, Leon Chang, Brian P. Scott, Michael Webb, Sandra R. Chaplan et al. · 2008 · Bioorganic & Medicinal Chemistry Letters
2. Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase
   Katerina Otrubova, Benjamin F. Cravatt, Dale L. Boger · 2014 · Journal of Medicinal Chemistry
3. The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain
   Natalia Małek, Magdalena Kostrzewa, Wioletta Makuch, Agnieszka Pajak, Mateusz Wojciech Kucharczyk, Fabiana Piscitelli, Barbara Przewłocka, Vincenzo Di Marzo, Katarzyna Starowicz · 2016 · Pharmacological Research
4. Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
   Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha R. Savinainen, Rashid A. Giniatullin · 2023 · The Journal of Headache and Pain
5. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse
   James A. Palmer, Emiliano S. Higuera, Leon Chang, Sandra R. Chaplan · 2008 · Neuroscience
6. The Pharmacology of the Cannabinoid System—A Question of Efficacy and Selectivity
   Christopher John Fowler · 2007 · Molecular Neurobiology
7. The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain
   Xiaowei Dong, Yuping Jia, Sherry X. Lu, Xiaoping Zhou, Mary E. Cohen-Williams, Robert A. Hodgson, Huiqing Li, Tony Priestley · 2007 · Psychopharmacology
8. Metabolism of Anandamide into Eoxamides by 15‐Lipoxygenase‐1 and Glutathione Transferases
   Pontus K. A. Larsson Forsell, Åsa Brunnström, Malin Johannesson, Hans‐Erik Claesson · 2012 · Lipids
9. Anandamide in primary sensory neurons: too much of a good thing?
   João de Sousa Valente, Angelika Varga, Kajaluxy Ananthan, Ankur Khajuria, I. Nagy · 2014 · European Journal of Neuroscience
10. The endocannabinoid system: Novel targets for treating cancer induced bone pain
    Jia Sun, Ya‐Qun Zhou, Shuping Chen, Xiaomei Wang, Bingyang Xu, Danyang Li, Yuke Tian, Dawei Ye · 2019 · Biomedicine & Pharmacotherapy
11. 3‐Heterocycle‐Phenyl N‐Alkylcarbamates as FAAH Inhibitors: Design, Synthesis and 3D‐QSAR Studies
    Heikki Käsnänen, Mikko J. Myllymäki, Anna Minkkilä, Antti O. Kataja, Susanna M. Saario, Tapio Nevalainen, Ari M. P. Koskinen, Antti Poso · 2009 · ChemMedChem
12. Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain
    Adriana Della Pietra, Juha R. Savinainen, Rashid A. Giniatullin · 2022 · International Journal of Molecular Sciences
13. Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe
    Xiangge Tian, Tao Liu, Lu Li, Bo Shao, Dahong Yao, Lei Feng, Jingnan Cui, Tony D. James, Xiaochi Ma · 2020 · Analytical Chemistry
14. Attenuation of Cystitis and Pain Sensation in Mice Lacking Fatty Acid Amide Hydrolase
    Zunyi Wang, Peiqing Wang, Cecilia J. Hillard, Dale E. Bjorling · 2014 · Journal of Molecular Neuroscience
15. Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder
    Mariah M. Wu, Xinwen Zhang, Melissa J. Asher, Stanley A. Thayer · 2019 · Brain Research
16. Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy
    Michael A. Wortley, John J. Adcock, Eric D. Dubuis, Sarah A. Maher, Sara Jane Bonvini, Isabelle Delescluse, Ross A. Kinloch, Gordon McMurray, Christelle Huguet, Marianthi Papakosta et al. · 2017 · European Respiratory Journal
17. Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency
    Gaochao Tian, Kathy A. Paschetto, Farzin Gharahdaghi, Euan Gordon, Dee E. Wilkins, Xincai Luo, Clay W. Scott · 2011 · Biochemistry
18. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats
    Hasanein, Parisa, Parviz, Mohsen, Keshavarz, Mansoor, Roohbakhsh, Ali · 2009 · Canadian Journal of Physiology and Pharmacology
19. FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats
    Michael A. Burman, Kerribeth Szolusha, Rebecca H. Bind, Kristen Kerney, Dale L. Boger, Edward J. Bilsky · 2016 · Behavioural Brain Research
20. The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors
    John M. Keith, Mark S. Tichenor, Richard L. Apodaca, Wei Xiao, William M. Jones, Mark J. Seierstad, Joan M. Pierce, James A. Palmer, Michael Webb, Mark J. Karbarz et al. · 2016 · Bioorganic & Medicinal Chemistry Letters
21. Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide
    Luciano De PETROCELLIS, Rupal Deva, Francesco Mainieri, Michael Schaefer, Tiziana Bisogno, Roberto Ciccoli, Alessia Ligresti, Kerstin Hill, Santosh Nigam, Giovanni Appendino et al. · 2008 · Journal of Lipid Research
22. N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception
    José Eduardo Roa‐Coria, Gabriel Navarrete‐Vázquez, Christopher John Fowler, Francisco Javier Flores‐Murrieta, Myrna Déciga‐Campos, Vinicio Granados‐Soto · 2012 · Life Sciences
23. Activity of FAAH-Inhibitor JZP327A in an Experimental Rat Model of Migraine
    Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli · 2023 · International Journal of Molecular Sciences
24. On the Biomedical Properties of Endocannabinoid Degradation and Reuptake Inhibitors: Pre-clinical and Clinical Evidence
    Karen Jaqueline Paredes-Ruiz, Karla Chavira-Ramos, Mario Orozco‐Morales, Çi̇men Karasu, Alexey A. Tinkov, Michael Aschner, Abel Santamarı́a, Ana Laura Colín-González · 2021 · Neurotoxicity Research
25. Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors
    Yan Qiu, Jie Ren, Hongwei Ke, Yang Zhang, Qi Gao, Longhe Yang, Can‐Zhong Lu, Yuhang Li · 2017 · RSC Advances
26. Targeting the Cannabinoid System to Produce Analgesia
    Devi Rani Sagar, Maulik D. Jhaveri, Victoria Chapman · 2009 · Current topics in behavioral neurosciences
27. A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screening
    Johan Brengdahl, Christopher John Fowler · 2006 · Analytical Biochemistry
28. The Development of Cannabinoids as Therapeutic Agents in the United States
    Conor H. Murray, Brenda M. Gannon, Peter John Winsauer, Ziva D. Cooper, Marcus Sherode Delatte · 2024 · Pharmacological Reviews
29. The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using 19 F-NMR
    Jianqin Zhuang, De‐Ping Yang, Spyros P. Nikas, Jianhong Zhao, Jianxin Guo, Alexandros Makriyannis · 2013 · The AAPS Journal
30. Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
    Bright N. Okine, Jessica C. Gaspar, Manish K. Madasu, Weredeselam M. Olango, Brendan Harhen, Michelle Roche, David P. Finn · 2016 · Brain Research
31. Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents
    Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona V. Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher John Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis · 2021 · Journal of Enzyme Inhibition and Medicinal Chemistry
32. Injury-induced activation of the endocannabinoid system promotes axon regeneration
    Sara Martínez‐Torres, Francina Mesquida-Veny, José Antonio del Rı́o, Arnau Hervera · 2023 · iScience
33. Discovery of potent, non-carbonyl inhibitors of fatty acid amide hydrolase (FAAH)
    Sumithra Gowlugari, Jeff DeFalco, Margaret T.L. Nguyen, Carl J. Kaub, Candace Chi, Matthew A. J. Duncton, Daniel E. Emerling, Michael G. Kelly, John Kincaid, Fabien Vincent · 2012 · MedChemComm
34. Chapter 4.5 The endocannabinoid system and anxiety responses
    Bortolato, Marco, Piomelli, Daniele · 2008 · Handbook of Behavioral Neuroscience
35. Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide] in rats: Potential for the treatment of inflammatory pain
    Toshiya Endo, Takashi Takeuchi, Shunsuke Maehara · 2020 · Pharmacology Research & Perspectives
36. Inhibition of fatty acid amide hydrolase (FAAH) reduces spinal nociceptive responses and expression of spinal long-term potentiation (LTP)
    Guro S. Eriksen, Line Melå Jacobsen, Aqsa Mahmood, Linda Margareth Pedersen, Johannes Gjerstad · 2011 · Brain Research Bulletin
37. Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review
    Oscar David Lopez-Cortes, Francisco Trujillo-Sánchez, Érika Sierra-Ruelas, Erika Martínez‐López, Vincenzo Di Marzo, Barbara Vizmanos-Lamotte · 2023 · International Journal of Obesity
38. Pharmacological Modulation of Pain
    A. Dray · 2008 · Elsevier eBooks
39. N -aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
    Naresh Sunduru, Mona V. Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher John Fowler, Mikael Elofsson · 2017 · Journal of Enzyme Inhibition and Medicinal Chemistry
40. 2020 Foresight: Envisioning Therapeutic Innovations for Pain
    M. Hamza, R. Dionne · 2009 · Drug Discovery Today : Therapeutic Strategies
41. Understanding and Targeting the Endocannabinoid System with Activity‐Based Protein Profiling
    Na Zhu, Antonius P. A. Janssen, Mario van der Stelt · 2023 · Israel Journal of Chemistry
42. Cannabinoid Receptor Mediated Analgesia: Novel Targets for Chronic Pain States
    Victoria Chapman, David A. Kendall, Devi Rani Sagar · 2009 · Springer eBooks
43. Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia
    Victoria L. Woyach, Katherine Sherman, Cecilia J. Hillard, Francis A. Hopp, Quinn H. Hogan, Caron Dean · 2022 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
44. Molecular Dynamics Analysis of FAAH Complexed with Anandamide
    Sérgio Filipe Sousa, João T. S. Coimbra, Pedro Alexandrino Fernandes, Tiziana Marino, Maria João Ramos, Nino Russo · 2015 · Progress in theoretical chemistry and physics
45. Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities
    Christopher John Fowler, Lina Thors · 2007 · Springer eBooks
46. The cannabinoid system and its role in nociception
    Massimiliano Beltramo · 2016 · Wiley eBooks
47. Inactivation Mechanism of the Fatty Acid Amide Hydrolase Inhibitor BIA 10‐2474
    Nuno M. F. S. A. Cerqueira, Marco Neves, Juliana F. Rocha, Patrício Soares‐da Silva, P. Nuno Palma · 2022 · ChemBioChem
48. Endocannabinoids in pain modulation
    Victoria Chapman, Stephen George Woodhams · 2025 · Handbook of behavioral neuroscience
49. Additional file 2 of Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
    Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Juha R. Savinainen, Rashid A. Giniatullin · 2024 · Figshare
50. Additional file 1 of Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
    Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Juha R. Savinainen, Rashid A. Giniatullin · 2024 · Figshare
51. Additional file 3 of Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
    Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Juha R. Savinainen, Rashid A. Giniatullin · 2024 · Figshare
52. Endocannabinoid system, inflammation, and mental well-being
    Ayesha Zafar Iqbal, Suet‐Kei Wu, Muhammad Yaseen, Patricia Marest Suwindi, Jane Pei‐Chen Chang, Kuan‐Pin Su · 2026 · Elsevier eBooks
53. Cannabis
    George F. Koob, Michael A. Arends, Mandy L. McCracken, Michel Le Moal · 2026 · Elsevier eBooks
54. BindingDB Entry 50030672: beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.
    BindingDB · 2010 · UC San Diego
55. BindingDB Entry 2926: Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase.
    BindingDB · 2008 · UC San Diego
56. BindingDB Entry 2993: Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
    BindingDB · 2009 · UC San Diego
57. BindingDB Entry 50022512: Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
    BindingDB · 2025 · UC San Diego
58. BindingDB Entry 50047561: The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.
    BindingDB · 2017 · UC San Diego
59. BindingDB Entry 50026664: Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
    BindingDB · 2010 · UC San Diego
60. BindingDB Entry 50038639: Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
    BindingDB · 2012 · UC San Diego
61. BindingDB Entry 50026873: Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.
    BindingDB · 2010 · UC San Diego
62. BindingDB Entry 4626: Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
    BindingDB · 2011 · UC San Diego
63. BindingDB Entry 50043951: Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase.
    BindingDB · 2014 · UC San Diego
64. BindingDB Entry 50038126: Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
    BindingDB · 2012 · UC San Diego
65. BindingDB Entry 5709: Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.
    BindingDB · 2013 · UC San Diego
66. BindingDB Entry 50038737: Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
    BindingDB · 2012 · UC San Diego
67. BindingDB Entry 50038153: Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
    BindingDB · 2012 · UC San Diego
68. BindingDB Entry 50001937: Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
    BindingDB · 2020 · UC San Diego
69. BindingDB Entry 50030892: X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
    BindingDB · 2010 · UC San Diego
70. BindingDB Entry 50033248: Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
    BindingDB · 2011 · UC San Diego
71. BindingDB Entry 50033120: Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
    BindingDB · 2011 · UC San Diego
72. BindingDB Entry 50033742: The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
    BindingDB · 2012 · UC San Diego
73. Cannabinoid Type-1 Receptor Reduces Pain and Neurotoxicity Produced by Chemotherapy
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