Is there an upper age limit for bone marrow transplantation?

Popplewell, LL; Forman, SJ

doi:10.1038/sj.bmt.1703382

Cited by 42Hematopoietic Stem Cell TransplantationBlood transfusion and managementHematological disorders and diagnostics

Is there an upper age limit for bone marrow transplantation?

Popplewell, LL, Forman, SJ·2002·Bone Marrow Transplantation

DOI 10.1038/sj.bmt.1703382

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Abstract

Advances in hematopoietic cell transplantation have reduced the toxicity of both allogeneic and autologous transplantation. Decisions regarding the feasibility of transplantation should be individualized, and based upon physiological rather than chronological age.

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Crossref · 10.1038/sj.bmt.1703382

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Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments, whereas signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs.
“Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments143,144. By contrast, signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs145.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [144]

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Authors: Popplewell, L., & Forman, S.
Venue: Bone Marrow Transplantation
Publisher: Springer Science and Business Media LLC
Published: 2002-02-01
Volume: 29
Issue: 4
Pages: 277-284
ISSN: 0268-3369 (ISSN-L)
1476-5365
DOI: 10.1038/sj.bmt.1703382
OpenAlex: W1986672266
Cited by: 42
References: 57
Citations by year: 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 0.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Bone Marrow Transplantation (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA33572-19S4, P01-CA 30206, P01CA030206, P30CA033572)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Biochemistry › Blood transfusion and management
Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
Keywords: upper age limit, hematopoietic stem cell transplantation, allogeneic transplantation, autologous transplantation, transplant toxicity, physiological age, transplant eligibility
MeSH terms: Acute Disease, Adult, Age Factors, Aged, Chronic Disease, Graft vs Host Disease, Humans, Lymphocyte Depletion, Middle Aged, Prognosis, Transplantation, Autologous, Transplantation, Homologous, Bone Marrow Transplantation, Treatment Outcome, Hematopoietic Stem Cell Transplantation, Hematologic Neoplasms

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